Physiological Reports, 2019 Abdominal aortic aneurysms (AAAs) are a progressive dilation of the aorta that is characterized by an initial influx of inflammatory cells followed by a pro‐inflammatory, migratory, proliferative, and eventually apoptotic smooth muscle cell phenotype. In
Morgan Salmon +4 more
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DNA methylation presents distinct binding sites for human transcription factors
eLife, 2013 DNA methylation, especially CpG methylation at promoter regions, has been generally considered as a potent epigenetic modification that prohibits transcription factor (TF) recruitment, resulting in transcription suppression.
Shaohui Hu +17 more
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Mechanical stretch suppresses microRNA-145 expression by activating extracellular signal-regulated kinase 1/2 and upregulating angiotensin-converting enzyme to alter vascular smooth muscle cell phenotype. [PDF]
PLoS ONE, 2014 Phenotype modulation of vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis of various vascular diseases, including hypertension and atherosclerosis.
Bo Hu +6 more
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Role of CD133/NRF2 Axis in the Development of Colon Cancer Stem Cell-Like Properties
Frontiers in Oncology, 2022 Cancer stem cells (CSCs) exhibit intrinsic therapy/stress resistance, which often cause cancer recurrence after therapy. In this study, we investigated the potential relationship between the cluster of differentiation (CD)-133, a CSC marker of colon ...
Jimin Park +6 more
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Loss of Schlafen3 influences the expression levels of Schlafen family members in ileum, thymus, and spleen tissue [PDF]
PeerJ, 2020 Background The Schlafen (Slfn) family proteins are important for regulation of cell growth, cell differentiation and cell cycle progression. We sought to distinguish Slfn family expression in Slfn3 knockout (KO) mice after RNA sequencing analysis of ...
Emilie E. Vomhof-DeKrey +2 more
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Factor Investing with a Deep Multi-Factor Model [PDF]
arXiv, 2022 Modeling and characterizing multiple factors is perhaps the most important step in achieving excess returns over market benchmarks. Both academia and industry are striving to find new factors that have good explanatory power for future stock returns and good stability of their predictive power.
arxiv
Differential expression of Kruppel-like factor 4 in cancers of the breast.
, 2021 Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding Kruppel-like factor 4,
openaire +2 more sources
Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4) [PDF]
Nucleic Acids Research, 1999 Gut-enriched Krüppel-like factor (GKLF, KLF4) is an epithelial-specific transcription factor whose expression is associated with growth arrest. In order to understand the mechanisms regulating expression of the gene encoding GKLF, we isolated a genomic clone containing murine GKLF. The gene spans 5.3 kb and contains four exons.
Channing S. Mahatan +3 more
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Background: Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the progression of liver fibrosis and cirrhosis and responsible for its clinical complications.
Tingting Su +7 more
doaj
ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis
Cell Death and Disease, 2021 Acute pancreatitis (AP), an acute inflammatory process, can be difficult to diagnose. Activating transcription factor 4 (ATF4) has been reported to participate in the pathogenesis of AP.
Xiaofeng Deng +3 more
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