Results 71 to 80 of about 157,775 (261)
Krüppel-like factor 4 transcriptionally regulates TGF-β1 and contributes to cardiac myofibroblast differentiation. [PDF]
PLoS ONE, 2013 Angiotensin II (Ang II) plays a major role in the pathogenesis of cardiac fibrosis in hypertension. It is known that Ang II induces TGF-β1 expression.
Yi Zhang +5 more
doaj +1 more source
MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]
, 2016 Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo +13 more
core +4 more sources
Pathology & Oncology Research, 2011 Kruppel-like factors (KLFs) are import modulators of cell proliferation, differentiation, and transformation and have recently been considered possible prognostic factors in breast cancer. In this study, we investigated the correlation between KLF4 and KLF5 expression and the clinical manifestations of breast cancer by immunohistochemical analysis.
Chih-Jung, Chen +5 more
openaire +2 more sources
Journal of Neuroinflammation, 2010 Background Activation of microglia, the resident macrophages of the central nervous system (CNS), is the hallmark of neuroinflammation in neurodegenerative diseases and other pathological conditions associated with CNS infection.
Das Sulagna +3 more
doaj +1 more source
A novel role of Krüppel-like factor 4 in Zhikong scallop Chlamys farreri during spermatogenesis. [PDF]
PLoS ONE, 2017 Krüppel-like factor 4 (KLF4) is a kind of zinc finger transcription factor, which is involved in terminal differentiation of epithelial cells and reprogramming of somatic cells to induced pluripotent stem (iPS) cells in mammals.
Dandan Yang +5 more
doaj +1 more source
A systems biology analysis of brain microvascular endothelial cell lipotoxicity. [PDF]
, 2014 BackgroundNeurovascular inflammation is associated with a number of neurological diseases including vascular dementia and Alzheimer's disease, which are increasingly important causes of morbidity and mortality around the world.
Aung, Hnin H +3 more
core +2 more sources
Kruppel-like Factor 4 Regulates Laminin α3A Expression in Mammary Epithelial Cells [PDF]
Journal of Biological Chemistry, 2001 Laminin-5, the major extracellular matrix protein produced by mammary epithelial cells, is composed of three chains (designated alpha3A, beta3, and gamma2), each encoded by a separate gene. Laminin-5 is markedly down-regulated in breast cancer cells. Little is known about the regulation of laminin gene transcription in normal breast cells, nor about ...
K A, Miller +7 more
openaire +2 more sources
PLoS ONE, 2014 The role of different lineage specific transcription factors in directing hematopoietic cell fate towards myeloid lineage is well established but the status of epigenetic modifications has not been defined during this important developmental process.
Manjula Karpurapu +9 more
doaj +1 more source
Kruppel-Like Factor 4 (KLF4) and its Regulation on Mitochondrial Homeostasis
Journal of Stem Cell Research & Therapy, 2018 Mitochondria are vital organelles that supply ATP and other energy metabolites to meet the bioenergetics demands of the cell. In environments of stress or increased energy requirement, mitochondria are highly dynamic and can undergo biogenesis, fusion/fission, or autophagy.
Tung, Brian, Xia, Shuli
openaire +2 more sources
Kruppel-like Factor 4 Abrogates Myocardin-induced Activation of Smooth Muscle Gene Expression [PDF]
Journal of Biological Chemistry, 2005 Platelet-derived growth factor BB (PDGF-BB) has been shown to be an extremely potent negative regulator of smooth muscle cell (SMC) differentiation. Moreover, previous studies have demonstrated that the Kruppel-like transcription factor (KLF) 4 potently represses the expression of multiple SMC genes.
Yan, Liu +5 more
openaire +2 more sources