Results 111 to 120 of about 193,609 (276)
Veterinary Medicine and Science, 2021 KLF3 is a member of the Kruppel‐like factor (KLF) family of transcription factors, and plays an important role in several biological processes, including adipogenesis, erythropoiesis and B‐cell development.
Weijia Wang +8 more
doaj +1 more source
A matter of time: Using dynamics and theory to uncover mechanisms of transcriptional bursting [PDF]
, 2020 Eukaryotic transcription generally occurs in bursts of activity lasting minutes to hours; however, state-of-the-art measurements have revealed that many of the molecular processes that underlie bursting, such as transcription factor binding to DNA, unfold on timescales of seconds.
arxiv +1 more source
MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4 [PDF]
, 2011 The role of microRNA-1 (miR-1) has been studied in cardiac and skeletal muscle differentiation. However, it remains unexplored in vascular smooth muscle cells (SMCs) differentiation. The aim of this study was to uncover novel targets of and shed light on
Changqing Xie +9 more
core +2 more sources
Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells. [PDF]
PLoS ONE, 2016 BACKGROUND:Fibulin-5 is an extracellular matrix glycoprotein that plays critical roles in vasculogenesis and embryonic development. Deletion of Fibulin-5 in mice results in enhanced skin vascularization and upregulation of the angiogenesis factor ...
Wilson Chan +6 more
doaj +1 more source
The Krüppel-like transcription factor 6 gene in sporadic pituitary tumours. [PDF]
Endocrine-related cancer, 2003 The oncogenes and/or tumour suppressor genes which may be involved in the transformation process for the vast majority of pituitary tumours remain unknown. There is substantial evidence for derangement of cell cycle control in such tumours, but cell cycle protein mutations identified in other human malignancies are restricted to only a very small ...
Vax, V +4 more
openaire +2 more sources
Genome-wide discovery of modulators of transcriptional interactions in human B lymphocytes [PDF]
RECOMB'06 Proceedings, LNCS 3909, Springer, 2006, 2005 Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription factor and its target(s). These include, among others, transcription factor activation by phosphorylation and acetylation, formation of active complexes with one or more co-factors, and ...
arxiv +1 more source
Plants, 2022 Lipid metabolism disorder is the most critical risk factor for atherosclerosis, and the process involves lipid deposition in the arterial intima. In Taiwan, antcin K, an active triterpenoid from the fruiting bodies of Antrodia camphorata, has been ...
Chen-Wen Lu +5 more
doaj +1 more source
Patterns of subnet usage reveal distinct scales of regulation in the transcriptional regulatory network of Escherichia coli [PDF]
, 2010 The set of regulatory interactions between genes, mediated by transcription factors, forms a species' transcriptional regulatory network (TRN). By comparing this network with measured gene expression data one can identify functional properties of the TRN and gain general insight into transcriptional control.
arxiv +1 more source
The lower bound on the precision of transcriptional regulation [PDF]
Phys. Rev. E 90 (2014) 032708, 2014 The diffusive arrival of transcription factors at the promoter sites on the DNA sets a lower bound on how accurately a cell can regulate its protein levels. Using results from the literature on diffusion-influenced reactions, we derive an analytical expression for the lower bound on the precision of transcriptional regulation.
arxiv +1 more source
Hepatology Communications, 2022 Liver cancer is an aggressive cancer associated with a poor prognosis. Development of therapeutic strategies for liver cancer requires fundamental research using suitable experimental models. Recent progress in direct reprogramming technology has enabled
Takeshi Goya +6 more
doaj +1 more source