Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Prognostic value and immunological role of Kruppel-like transcription factor 9 gene in pan-carcinoma
Medicine, 2022 Objective: To investigate the correlation between the expression of Kruppel-like transcription factor 9 (KLF9) and the prognostic value of tumors as well as its relationship with tumor immune invasion. Methods: A series of bioinformatics methods were used to analyze the relationship
Weichao Cai, Yecheng Li, Weihong Cao
openaire +2 more sources
Erythroid Kruppel-like factor directly activates the basic Kruppel-like factor gene in erythroid cells [PDF]
, 2007 The Sp/Kriippel-like factor (Sp/KIf) family is comprised of around 25 zinc finger transcription factors that recognize CACCC boxes and GC-rich elements.
Crossley, Merlin +6 more
core +1 more source
Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway. [PDF]
, 2017 Recent studies have linked branched-chain amino acid (BCAA) with numerous metabolic diseases. However, the molecular basis of BCAA's roles in metabolic regulation remains to be established.
Dong, Weibing +5 more
core +2 more sources
Kruppel‐like transcription factor KLF8 regulates of early adipocyte differentiation
The FASEB Journal, 2012 KLF8 is a zinc‐finger transcription factor known to play an essential role in cell cycle and differentiation. However, its physiological roles and functions in 3T3‐L1 cells remain relatively unclear. In the present study, we showed that KLF8 acts as a key regulator controlling adipocyte differentiation.
Hyo Jung Kim +5 more
openaire +1 more source
Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages [PDF]
Journal of Biological Chemistry, 2004 Transcription of interleukin (IL)-12 p40 in myeloid cells is attributed to the recruitment of multiple activated transcription factors such as nuclear factor kappaB (NFkappaB), CCAAT enhancer-binding protein beta, ets-2, PU.1, and so forth. We now provide the first description of the human erythroid Kruppel-like factor (EKLF) in human primary ...
Qi, Luo +5 more
openaire +2 more sources
Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)
Cancer Cell International, 2012 We have investigated the role of erythroid transcription factors mRNA expression in patients with acute myeloid leukemia (AML) in the context of cytogenetic and other prognostic molecular markers, such as FMS-like Tyrosine Kinase 3 (FLT3), Nucleophosmin ...
Ayala Rosa +2 more
doaj +1 more source
A systems biology analysis of brain microvascular endothelial cell lipotoxicity. [PDF]
, 2014 BackgroundNeurovascular inflammation is associated with a number of neurological diseases including vascular dementia and Alzheimer's disease, which are increasingly important causes of morbidity and mortality around the world.
Aung, Hnin H +3 more
core +2 more sources
Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis [PDF]
Proceedings of the National Academy of Sciences, 1998 Wound repair in the liver induces altered gene expression in stellate cells (resident mesenchymal cells) in a process known as “activation.” A zinc finger transcription factor cDNA, zf9 , was cloned from rat stellate cells activated in vivo .
V, Ratziu +7 more
openaire +2 more sources
Acta Medica, 2009 Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa.
Pavel Kuneš +2 more
doaj +1 more source