Results 21 to 30 of about 193,609 (276)

Cutting Edge: The Transcription Factor Kruppel-Like Factor 4 Regulates the Differentiation of Th17 Cells Independently of RORγt [PDF]

The Journal of Immunology, 2010
Abstract Th17 cells play a significant role in inflammatory and autoimmune responses. Although a number of molecular pathways that contribute to the lineage differentiation of T cells have been discovered, the mechanisms by which lineage commitment occurs are not fully understood.
Lori Lebson, Jason M. Rosenzweig, Jonathan K. Alder, Anne R. Gocke, Curt I. Civin, Katharine A. Whartenby, Peter A. Calabresi   +6 more
openaire   +5 more sources

Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages [PDF]

Journal of Biological Chemistry, 2004
Transcription of interleukin (IL)-12 p40 in myeloid cells is attributed to the recruitment of multiple activated transcription factors such as nuclear factor kappaB (NFkappaB), CCAAT enhancer-binding protein beta, ets-2, PU.1, and so forth. We now provide the first description of the human erythroid Kruppel-like factor (EKLF) in human primary ...
Luis J. Montaner, Sharon M. Wahl, James J. Bieker, Merlin Crossley, Qi Luo, Xiaojing Ma   +5 more
openaire   +4 more sources

Prognostic value and immunological role of Kruppel-like transcription factor 9 gene in pan-carcinoma

Medicine, 2022
Objective: To investigate the correlation between the expression of Kruppel-like transcription factor 9 (KLF9) and the prognostic value of tumors as well as its relationship with tumor immune invasion. Methods: A series of bioinformatics methods were used to analyze the relationship
Weichao Cai, Yecheng Li, Weihong Cao
openaire   +3 more sources

Transcriptional Activity of Erythroid Kruppel-like Factor (EKLF/KLF1) Modulated by PIAS3 (Protein Inhibitor of Activated STAT3) [PDF]

Journal of Biological Chemistry, 2015
Erythroid Kruppel-like factor (EKLF or KLF1) is a transcription factor crucial for red cell development that is directly involved in regulation of a large number of erythroid genes. EKLF serves mostly as an activator of expression of these genes; however, it can act also as a repressor.
Miroslawa Siatecka, Shefali Soni, Antanas Planutis, James J. Bieker   +3 more
openaire   +4 more sources

The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2)

Blood, 2014
Key Points Transcription factor KLF2 is a critical determinant of vascular thrombosis. The antithrombotic effect noted with bortezomib is KLF2 dependent.
Alvin H. Schmaier, Hong Shi, Lalitha Nayak, Zhiyong Lin, Mukesh K. Jain, G. Brandon Atkins   +5 more
openaire   +5 more sources

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis [PDF]

Journal of Clinical Investigation, 2015
Mitochondrial homeostasis is critical for tissue health, and mitochondrial dysfunction contributes to numerous diseases, including heart failure. Here, we have shown that the transcription factor Kruppel-like factor 4 (KLF4) governs mitochondrial biogenesis, metabolic function, dynamics, and autophagic clearance.
Ling Lai, Domenick A. Prosdocimo, P. Christian Schulze, Mukesh K. Jain, Xudong Liao, Panjamaporn Sangwung, Lilei Zhang, Charles L. Hoppel, Mariana G. Rosca, Guangjin Zhou, Daniel P. Kelly, Hisashi Fujioka, E. Dale Abel, Teresa C. Leone, Yuan Lu, Jonathan S. Stamler, Puneet Anand, Rongli Zhang, Fang Ye   +18 more
openaire   +4 more sources

GATA Binding Protein 3 Is a Direct Target of Kruppel-Like Transcription Factor 7 and Inhibits Chicken Adipogenesis [PDF]

Frontiers in Physiology, 2020
Kruppel-like transcription factor 7 (KLF7) is a negative regulator of adipogenesis, however, its precise mechanism is poorly understood. Our previous KLF7 ChIP-seq analysis showed that one of the KLF7 binding peaks was present upstream of GATA binding protein 3 (GATA3) in chicken preadipocytes.
Yingning Sun, Yingning Sun, Yingning Sun, Yingning Sun, Zhao Jin, Xinyang Zhang, Xinyang Zhang, Xinyang Zhang, Tingting Cui, Tingting Cui, Tingting Cui, Tingting Cui, Wenjian Zhang, Wenjian Zhang, Wenjian Zhang, Shuli Shao, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +21 more
openaire   +5 more sources

Role of kruppel-like transcription factors in adipogenesis

Developmental Biology, 2013
The zinc-finger transcription factors of the kruppel-like factor family (KLF) are critical in many physiological and pathological processes including cell proliferation, differentiation, inflammation, and apoptosis. Recently, there is increasing evidence that suggests these KLFs have an important role in fat biology.
Zeni Wu, Suqing Wang
openaire   +4 more sources

Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1.

Journal of Biological Chemistry, 1994
Erythroid Kruppel-like factor (EKLF) is an erythroid-specific transcription factor that binds a CACCC motif found in the human beta-globin gene promoter. We have studied the promoter of the EKLF gene and identified binding sites for the transcription factors GATA-1 and CCAAT-binding Protein 1 (CP1). We show that both types of binding sites are required
Alice P. Tsang, Stuart H. Orkin, Merlin Crossley, J J Bieker   +3 more
openaire   +4 more sources

Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis [PDF]

Proceedings of the National Academy of Sciences, 1998
Wound repair in the liver induces altered gene expression in stellate cells (resident mesenchymal cells) in a process known as “activation.” A zinc finger transcription factor cDNA, zf9 , was cloned from rat stellate cells activated in vivo .
Colin Collins, Susan Jensen, Qi Dang, Vlad Ratziu, E Shaulian, Avraham Lalazar, Scott L. Friedman, Linda Wong   +7 more
openaire   +5 more sources