Kv1.3 - Open Access .click

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Benzamide derivatives as blockers of Kv1.3 ion channel

Bioorganic & Medicinal Chemistry Letters, 2003
The voltage-gated potassium channel, Kv1.3, is present in human T-lymphocytes. Blockade of Kv1.3 results in T-cell depolarization, inhibition of T-cell activation, and attenuation of immune responses in vivo. A class of benzamide Kv1.3 channel inhibitors has been identified.
Shouwu, Miao +18 more
openaire +2 more sources

Molecular mapping of KCNE4-dependent regulation of Kv1.3

American Journal of Physiology-Cell Physiology
This work defines, for the first time, the interactions between a Kv1 ( Shaker) channel and a KCNE regulatory subunit. While the COOH-terminus of KCNE4 physically interacts with the channel, its transmembrane domain shapes the inactivation properties of the functional complex, fine-tuning the Kv1.3-dependent physiological response in leukocytes.
Daniel Sastre +7 more
openaire +3 more sources

Discovery of KV1.3 Ion Channel Inhibitors: Medicinal Chemistry Approaches and Challenges

Medicinal Research Reviews, 2021
Tihomir Tomasić, Steve Peigneur, Lucija Peterlin-Masic +2 more
exaly

An Activator of Voltage-Gated K⁺ Channels Kv1.1 as a Therapeutic Candidate for Episodic Ataxia Type 1

Proceedings of the National Academy of Sciences of the United States of America, 2023
Ruben J. Cauchi, Paola Imbrici, Mauro Pessia +2 more
exaly

KV1.3 BLOCKERS