Results 271 to 280 of about 40,027 (305)
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Journal of Proteome Research, 2021
We performed quantitative metabolic phenotyping of blood plasma in parallel with cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+) (n = 10) or SARS-CoV-2 (-) (n = 49).
N. Lawler +18 more
semanticscholar +1 more source
We performed quantitative metabolic phenotyping of blood plasma in parallel with cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+) (n = 10) or SARS-CoV-2 (-) (n = 49).
N. Lawler +18 more
semanticscholar +1 more source
Epilepsia, 1981
Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
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Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
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Measurement of Rat Brain Kynurenine Aminotransferase at Physiological Kynurenine Concentrations
Journal of Neurochemistry, 1991AbstractThe production of the neuroinhibitory and neuroprotective metabolite kynurenic acid (KYNA) was investigated in rat brain by examining its biosynthetic enzyme, kynurenine aminotransferase (KAT). By using physiological (low micromolar) concentrations of the substrate L‐kynurenine (KYN) and by determining the irreversible conversion of [3H] KYN to
E, Okuno +4 more
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1996
The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
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The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
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[89] l-Kynurenine and N1-formyl-l-kynurenine
1957Publisher Summary This chapter presents a procedure for the preparation of L-Kynurenine and N-Formyl-L-kynurenine. The principle for preparation of L-kynurenine states L-Tryptophan is acetylated with acetic anhydride by the method of du Vigneaud and Sealock. The N α -acetyl-L-tryptophan is ozonolyzed and hydrolyzed to L-kynurenine and isolated as the
V.H. Auerbach, W.E. Knox
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Kynurenine and Lipid Metabolism
1991Previous observations showed an increased total cholesterol and triglycerol content and decreased phospholipid and lecithin content in blood serum of patients with elevated kynurenine accumulation in blood serum after tryptophan loading, i.e. in the case of pyridoxal-5-phosphate (P-5-P) deficiency in the organism (Rudzite et al., 1988). The increase of
V, Rudzite, E, Jurika
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Nature, 1966
THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
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THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
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Kynurenine Aminotransferase in Hypercholesterolemic Rats
1996Nicotinic acid is used in the treatment of atherosclerosis for its hypolipidemic effects (Kritchevsky, 1971; Levy, 1980; Grundy et al., 1981; Altschul et al., 1995), which reduce triglycerides and also cholesterol. In mammals, nicotinic acid derives from the metabolism of tryptophan along the kynurenine pathway.
BERTAZZO, ANTONELLA +5 more
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Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase
European Journal of Medicinal Chemistry, 1996Abstract The structural requirements of the catalytic site of kynurenine aminotransferase (KAT), the enzyme responsible for the conversion of l -kynurenine (KYN) to kynurenic acid (KYNA), were examined using analogs and derivatives of KYN. KYNA production from KYN was monitored in rat brain homogenates and brain tissue slices.
M Varasi +7 more
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Kynurenine metabolism in multiple sclerosis
Acta Neurologica Scandinavica, 2005Objective--Excitatory amino acid receptors are involved in the normal physiology of the brain, and may play a role in the pathogenesis of neurological disorders such as Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc.
Hartai Zsuzsanna +5 more
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