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Kynurenine and Lipid Metabolism
1991Previous observations showed an increased total cholesterol and triglycerol content and decreased phospholipid and lecithin content in blood serum of patients with elevated kynurenine accumulation in blood serum after tryptophan loading, i.e. in the case of pyridoxal-5-phosphate (P-5-P) deficiency in the organism (Rudzite et al., 1988). The increase of
V, Rudzite, E, Jurika
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Inhibitors of the kynurenine pathway
European Journal of Medicinal Chemistry, 2000Strokes (intracranial thomboses or haemorrhaging) cause death and disability, but effective treatments are lacking. The metabolism of tryptophan leads to the generation of quinolinic acid, an agonist potentially neurotoxic at glutamate receptors, and kynurenic acid, an antagonist at the same population of receptors.
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Kynurenine Aminotransferase in Hypercholesterolemic Rats
1996Nicotinic acid is used in the treatment of atherosclerosis for its hypolipidemic effects (Kritchevsky, 1971; Levy, 1980; Grundy et al., 1981; Altschul et al., 1995), which reduce triglycerides and also cholesterol. In mammals, nicotinic acid derives from the metabolism of tryptophan along the kynurenine pathway.
BERTAZZO, ANTONELLA +5 more
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[89] l-Kynurenine and N1-formyl-l-kynurenine
1957Publisher Summary This chapter presents a procedure for the preparation of L-Kynurenine and N-Formyl-L-kynurenine. The principle for preparation of L-kynurenine states L-Tryptophan is acetylated with acetic anhydride by the method of du Vigneaud and Sealock. The N α -acetyl-L-tryptophan is ozonolyzed and hydrolyzed to L-kynurenine and isolated as the
V.H. Auerbach, W.E. Knox
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Characterization of human brain kynurenine aminotransferases using [3H]kynurenine as a substrate
Neuroscience, 1993The brain metabolite kynurenic acid is an established broad-spectrum antagonist at ionotropic excitatory amino acid receptors. In the human brain, two distinct enzymes are capable of synthesizing kynurenic acid from its bioprecursor L-kynurenine. Using [3H]kynurenine as the substrate, the two kynurenine aminotransferases (kynurenine aminotransferase I ...
W, Schmidt +3 more
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Effect of some xenobiotics on kynurenine hydrolase and kynurenine aminotransferase of mouse liver
Journal of Environmental Science and Health, Part B, 1983The effects of some xenobiotics on the activity of the B6-dependent kynurenine hydrolase (KH) and kynurenine aminotransferase (KATE) in mouse liver, were investigated. Polychlorinated biphenyl (Aroclor 1254) (400mg/kg/day x4) markedly decreased the activity of both enzymes. Benzo(a)pyrene (BP) and 3-methylcholanthrene (3-MC) (40mg/Kg/day x1) as well as
M H, Mostafa +6 more
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[Stress and the kynurenine pathway].
Orvosi hetilap, 2015The kynurenine pathway is the main route of tryptophan degradation which gives rise to several neuroactive metabolites. Kynurenic acid is an endogenous antagonist of excitatory receptors, which proved to be neuroprotective in the preclinical settings. Kynurenines have been implicated in the neuroendocrine regulatory processes.
Majláth Zsófia, Vécsei László
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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
Molecular Cell, 2022Alessandra Fiore +2 more
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Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia
Circulation Research, 2021Stephanie A Worton +2 more
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