Results 241 to 250 of about 37,687 (273)
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Inhibitors of the kynurenine pathway
European Journal of Medicinal Chemistry, 2000Strokes (intracranial thomboses or haemorrhaging) cause death and disability, but effective treatments are lacking. The metabolism of tryptophan leads to the generation of quinolinic acid, an agonist potentially neurotoxic at glutamate receptors, and kynurenic acid, an antagonist at the same population of receptors.
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Kynurenine Aminotransferase in Hypercholesterolemic Rats
1996Nicotinic acid is used in the treatment of atherosclerosis for its hypolipidemic effects (Kritchevsky, 1971; Levy, 1980; Grundy et al., 1981; Altschul et al., 1995), which reduce triglycerides and also cholesterol. In mammals, nicotinic acid derives from the metabolism of tryptophan along the kynurenine pathway.
BERTAZZO, ANTONELLA +5 more
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[Stress and the kynurenine pathway].
Orvosi hetilap, 2015The kynurenine pathway is the main route of tryptophan degradation which gives rise to several neuroactive metabolites. Kynurenic acid is an endogenous antagonist of excitatory receptors, which proved to be neuroprotective in the preclinical settings. Kynurenines have been implicated in the neuroendocrine regulatory processes.
Majláth Zsófia, Vécsei László
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[89] l-Kynurenine and N1-formyl-l-kynurenine
1957Publisher Summary This chapter presents a procedure for the preparation of L-Kynurenine and N-Formyl-L-kynurenine. The principle for preparation of L-kynurenine states L-Tryptophan is acetylated with acetic anhydride by the method of du Vigneaud and Sealock. The N α -acetyl-L-tryptophan is ozonolyzed and hydrolyzed to L-kynurenine and isolated as the
V.H. Auerbach, W.E. Knox
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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
Molecular Cell, 2022Simon Newstead, Marion Russier
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Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders
Cells, 2021Anna Krupa +2 more
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The Footprint of Kynurenine Pathway in Cardiovascular Diseases
International Journal of Tryptophan Research, 2022Moein Ala, Seyed Parsa Eftekhar
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The immune-kynurenine pathway in social anxiety disorder
Brain, Behavior, and Immunity, 2022Sabrina Mörkl +2 more
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