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Kynurenine Aminotransferase in Hypercholesterolemic Rats
1996Nicotinic acid is used in the treatment of atherosclerosis for its hypolipidemic effects (Kritchevsky, 1971; Levy, 1980; Grundy et al., 1981; Altschul et al., 1995), which reduce triglycerides and also cholesterol. In mammals, nicotinic acid derives from the metabolism of tryptophan along the kynurenine pathway.
BERTAZZO, ANTONELLA +5 more
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Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase
European Journal of Medicinal Chemistry, 1996Abstract The structural requirements of the catalytic site of kynurenine aminotransferase (KAT), the enzyme responsible for the conversion of l -kynurenine (KYN) to kynurenic acid (KYNA), were examined using analogs and derivatives of KYN. KYNA production from KYN was monitored in rat brain homogenates and brain tissue slices.
M Varasi +7 more
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Kynurenine metabolism in multiple sclerosis
Acta Neurologica Scandinavica, 2005Objective--Excitatory amino acid receptors are involved in the normal physiology of the brain, and may play a role in the pathogenesis of neurological disorders such as Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc.
Hartai Zsuzsanna +5 more
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T Cell Apoptosis by Kynurenines
2003Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that, expressed by different cell types, has regulatory effects on T cells resulting from tryptophan depletion in specific local tissue microenvironments. The discovery that inhibition of IDO activity reduces the survival of MHC-mismatched fetuses in mice and that the risk of fetal ...
FALLARINO, Francesca +6 more
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Cannabinoids: Glutamatergic Transmission and Kynurenines
2016The endocannabinoid system (ECS) comprises a complex of receptors, enzymes, and endogenous agonists that are widely distributed in the central nervous system of mammals and participates in a considerable number of neuromodulatory functions, including neurotransmission, immunological control, and cell signaling.
Ana Laura, Colín-González +2 more
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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
Molecular Cell, 2022Alessandra Fiore +2 more
exaly
Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia
Circulation Research, 2021Stephanie A Worton +2 more
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