Results 201 to 210 of about 34,126 (294)

Glycyrrhizic acid mitigates the risk of nicotine addiction and nicotine withdrawal: The modulation of kynurenine aminotransferase II. [PDF]

J Adv Pharm Technol Res
Rahmadi M, Aryani T, Anggraini D, Maheswara SR, Rahmaningtyas SD, Nurhan AD.   +5 more
europepmc   +1 more source

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

Tryptophan metabolism in glaucomatous optic neuropathy: from metabolic dysregulation to therapeutic opportunities. [PDF]

J Transl Med
Wang N, Yan T, Sun H, Guo W.
europepmc   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts. [PDF]

Metabolomics
Terra C, Terrier O, Le Gouellec A.
europepmc   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Periodontal inflammation and tryptophan-kynurenine metabolism in Parkinson's disease. [PDF]

Clin Oral Investig
Yilmaz M, Bakici A, Parlat R, Akpinar İN, Karaaslan R, Balci N, Toygar H, Kurgan Ş, Serdar MA, Kantarcı A.   +9 more
europepmc   +1 more source

Potential targets for renal cell carcinoma therapy: Mechanistic research and prospects of CAFs in renal cell carcinoma

VIEW, Volume 7, Issue 3, June 2026.
Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun, Jiankun Zhang, Meixi Liu, Xiyue Dong, Yuanshan Cui   +4 more
wiley   +1 more source

Nexus of IDO1/Kynurenine Pathway to T-Cell Exhaustion: Hypoxia-Induced Tryptophan Metabolism in Glioblastoma. [PDF]

Metabolites
Abikenari M, Nageeb G, Ha JH, Sjoholm MA, Liu J, Bergsneider B, Valenzuela J, Poe J, Bog Cho K, Verma R, Wu C, Sanker V, Medikonda R, Kim LH, Choi J, Banu MA, Lim M.   +16 more
europepmc   +1 more source

Nuclear Magnetic Resonance–Based Urinary Metabolic Profiling for Assessing Heat Stress–Related Incident Kidney Injury in Health‐Care Workers

GeoHealth, Volume 10, Issue 6, June 2026.
Abstract During the COVID‐19 pandemic, heat stress (HS) was a serious occupational risk for health‐care workers (HCWs) wearing personal protective equipment, which limits heat dissipation and increases the risk of kidney injury. In this exploratory study, we assessed HS‐related changes in the urinary metabolites of 38 HCWs working at mobile COVID‐19 ...
Cheng‐Yu Ting, Chi‐Tsung Chen, Tzu‐Hsin Yen, Jason Kai Wei Lee, Sheng‐Han Lee, Shang‐Jen Chang, Tzu‐Han Hung, Hao‐Jan Liang, Hsiao‐Yu Yang, Ching‐Yu Lin   +9 more
wiley   +1 more source