Results 211 to 220 of about 47,432 (263)
Some of the next articles are maybe not open access.
Advances in kynurenine analysis
Clinica Chimica Acta, 2023Kynurenine, the first product of tryptophan degradation via the kynurenine pathway, has become one of the most frequently mentioned biomarkers in recent years. Its levels in the body indicate the state of the human physiology. Human serum and plasma are the main matrixes used to evaluate kynurenine levels and liquid chromatography is the dominant ...
K, Mrštná +2 more
openaire +2 more sources
Journal of Neural Transmission, 2011
In parallel to serotonin synthesis, the major route of tryptophan catabolism is the kynurenine pathway, which produces neuroactive metabolites. Among these substances, kynurenic acid has potential neuroprotective action blocking glutamate release and glutamatergic neurotransmission.
Párdutz Árpád +5 more
openaire +3 more sources
In parallel to serotonin synthesis, the major route of tryptophan catabolism is the kynurenine pathway, which produces neuroactive metabolites. Among these substances, kynurenic acid has potential neuroprotective action blocking glutamate release and glutamatergic neurotransmission.
Párdutz Árpád +5 more
openaire +3 more sources
Epilepsia, 1981
Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
openaire +2 more sources
Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
openaire +2 more sources
Measurement of Rat Brain Kynurenine Aminotransferase at Physiological Kynurenine Concentrations
Journal of Neurochemistry, 1991AbstractThe production of the neuroinhibitory and neuroprotective metabolite kynurenic acid (KYNA) was investigated in rat brain by examining its biosynthetic enzyme, kynurenine aminotransferase (KAT). By using physiological (low micromolar) concentrations of the substrate L‐kynurenine (KYN) and by determining the irreversible conversion of [3H] KYN to
E, Okuno +4 more
openaire +2 more sources
1996
The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
openaire +2 more sources
The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
openaire +2 more sources
[89] l-Kynurenine and N1-formyl-l-kynurenine
1957Publisher Summary This chapter presents a procedure for the preparation of L-Kynurenine and N-Formyl-L-kynurenine. The principle for preparation of L-kynurenine states L-Tryptophan is acetylated with acetic anhydride by the method of du Vigneaud and Sealock. The N α -acetyl-L-tryptophan is ozonolyzed and hydrolyzed to L-kynurenine and isolated as the
V.H. Auerbach, W.E. Knox
openaire +1 more source
Kynurenine and Lipid Metabolism
1991Previous observations showed an increased total cholesterol and triglycerol content and decreased phospholipid and lecithin content in blood serum of patients with elevated kynurenine accumulation in blood serum after tryptophan loading, i.e. in the case of pyridoxal-5-phosphate (P-5-P) deficiency in the organism (Rudzite et al., 1988). The increase of
V, Rudzite, E, Jurika
openaire +2 more sources
Nature, 1966
THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
openaire +2 more sources
THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
openaire +2 more sources