Results 191 to 200 of about 28,282 (229)
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Binding of kynurenine to catecholamine
Amino Acids, 1992Papiliochrome II is a pale yellow pigment of butterflies and consists of one molecule each ofL-kynurenine and N-β-alanyldopamine (NBAD). The aromatic amino nitrogen of kynurenine is bonded to theβ-carbon of NBAD. There are isomers IIa and IIb which show opposite circular dichroism.
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Measurement of Rat Brain Kynurenine Aminotransferase at Physiological Kynurenine Concentrations
Journal of Neurochemistry, 1991AbstractThe production of the neuroinhibitory and neuroprotective metabolite kynurenic acid (KYNA) was investigated in rat brain by examining its biosynthetic enzyme, kynurenine aminotransferase (KAT). By using physiological (low micromolar) concentrations of the substrate L‐kynurenine (KYN) and by determining the irreversible conversion of [3H] KYN to
E, Okuno +4 more
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Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase
European Journal of Medicinal Chemistry, 1996Abstract The structural requirements of the catalytic site of kynurenine aminotransferase (KAT), the enzyme responsible for the conversion of l -kynurenine (KYN) to kynurenic acid (KYNA), were examined using analogs and derivatives of KYN. KYNA production from KYN was monitored in rat brain homogenates and brain tissue slices.
M Varasi +7 more
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Kynurenine and Lipid Metabolism
1991Previous observations showed an increased total cholesterol and triglycerol content and decreased phospholipid and lecithin content in blood serum of patients with elevated kynurenine accumulation in blood serum after tryptophan loading, i.e. in the case of pyridoxal-5-phosphate (P-5-P) deficiency in the organism (Rudzite et al., 1988). The increase of
V, Rudzite, E, Jurika
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Inhibitors of the kynurenine pathway
European Journal of Medicinal Chemistry, 2000Strokes (intracranial thomboses or haemorrhaging) cause death and disability, but effective treatments are lacking. The metabolism of tryptophan leads to the generation of quinolinic acid, an agonist potentially neurotoxic at glutamate receptors, and kynurenic acid, an antagonist at the same population of receptors.
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[89] l-Kynurenine and N1-formyl-l-kynurenine
1957Publisher Summary This chapter presents a procedure for the preparation of L-Kynurenine and N-Formyl-L-kynurenine. The principle for preparation of L-kynurenine states L-Tryptophan is acetylated with acetic anhydride by the method of du Vigneaud and Sealock. The N α -acetyl-L-tryptophan is ozonolyzed and hydrolyzed to L-kynurenine and isolated as the
V.H. Auerbach, W.E. Knox
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Kynurenine Aminotransferase in Hypercholesterolemic Rats
1996Nicotinic acid is used in the treatment of atherosclerosis for its hypolipidemic effects (Kritchevsky, 1971; Levy, 1980; Grundy et al., 1981; Altschul et al., 1995), which reduce triglycerides and also cholesterol. In mammals, nicotinic acid derives from the metabolism of tryptophan along the kynurenine pathway.
BERTAZZO, ANTONELLA +5 more
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[Stress and the kynurenine pathway].
Orvosi hetilap, 2015The kynurenine pathway is the main route of tryptophan degradation which gives rise to several neuroactive metabolites. Kynurenic acid is an endogenous antagonist of excitatory receptors, which proved to be neuroprotective in the preclinical settings. Kynurenines have been implicated in the neuroendocrine regulatory processes.
Majláth Zsófia, Vécsei László
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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
Molecular Cell, 2022, Simon Newstead, Marion Russier
exaly