An HPLC-Based Multi-Analyte Secretome Characterization Panel for Canine Adipose-Derived Mesenchymal/Stromal Stem Cells: Quantification of Adenosine, Kynurenine, IL-10, and TGF-β in Conditioned Media-A Pilot Feasibility Study. [PDF]
Int J Mol SciGarner S +7 more
europepmc +1 more source
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT The gut microbiome has emerged as a pivotal regulator of immunotherapy efficacy in non‐small cell lung cancer (NSCLC), with mounting evidence demonstrating that microbial‐immune crosstalk significantly influences therapeutic responses. Current research reveals that commensal bacteria modulate host immunity through complex metabolic and ...
Liming Zhu +4 more
wiley +1 more source
Artemether and Euphorbia factor L9 suppress kynurenine production through distinct effects on tryptophan metabolism. [PDF]
Biochem JCapatina AL +8 more
europepmc +1 more source
Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.Pseudomisopates rivas‐martinezii, a critically endangered Iberian endemic, reveals population‐specific chemotypes when analyzed by elemental analysis, FTIR, and GC–MS. Underground tissues from both populations share a convergent histidine‐derived metabolite profile, whereas aerial parts diverge markedly: La Serrota accumulates phenolic derivatives from
Eva Sánchez‐Hernández +5 more
wiley +1 more source
Plasma kynurenine to tryptophan ratio and arginine as biomarkers associated with GOLD classification and predicting poor prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease. [PDF]
Front Med (Lausanne)Tian Y +5 more
europepmc +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.We define a gut‐microbiota gradient linked to increasing depression severity and suicidal ideation, highlighting severity‐tracking taxa and pathways, particularly Bacteroides stercoris and the bacterial secretion‐system pathway, as potential microbial markers for suicide risk in MDD.
Liqin Liang +14 more
wiley +1 more source
The role of proinflammatory response and the kynurenine pathway in the association between childhood maltreatment and lifetime substance use disorder. [PDF]
Neurobiol StressÖstman L +11 more
europepmc +1 more source
The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis
Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley +1 more source
The Metabolic Architecture of Glaucoma: A Unified Framework of Cofactor Failure and Kynurenine Dysregulation. [PDF]
Int J Mol SciCaikovska L +6 more
europepmc +1 more source
The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy
eFood, Volume 7, Issue 3, June 2026.Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu +6 more
wiley +1 more source