Results 151 to 160 of about 47,432 (263)

Different Immune Cells Modified With Chimeric Antigen Receptors Are Being Applied to Ovarian Cancer: Which Is the Most Effective?

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Ovarian Cancer (OC), the deadliest gynecological malignancy, poses a major therapeutic challenge in advanced stages owing to its high recurrence rate and metastatic potential. In this regard, it is noteworthy that immunotherapy has recently gained significant attention in OC treatment, a phenomenon attributable to notable advances in over‐the ...
Liying Wang, Yisen Cao, Yuan Ren, Yuhang Zhang, Liang Wang   +4 more
wiley   +1 more source

Kynurenine Formamidase

Journal of Biological Chemistry, 1974
Cheryl B. Bailey, Conrad Wagner
openaire   +1 more source

Natural Products as the Modulators of Gut Microbiota: A Pool for the Development of New Treatment Against Obesity?

Food Frontiers, Volume 7, Issue 3, May 2026.
Natural compounds regulate gut microbiota by improving microbial balance and increasing probiotics, which boost short‐chain fatty acid production to alleviate insulin resistance and inflammation. Additionally, they stimulate appetite‐suppressing hormones through bile acid signaling, while inhibiting pathogenic bacteria to repair intestinal barrier ...
Hongchao Yuan, Yau‐Yuen Chan, Guang Chen, Lin Xu, Cheng Zhang, Guoyi Tang, Yibin Feng, Ning Wang   +7 more
wiley   +1 more source

Effectiveness of Melatonin‐Containing Foods on Promoting Sleep: A Scoping Review

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Effectiveness of melatonin‐containing foods promoting sleep: A scoping review. ABSTRACT Melatonin plays a crucial role in managing the body's sleep–wake cycle, and its natural occurrence in certain foods has generated interest in dietary interventions to improve sleep.
Tanzeela Nisar, Andrea Fuller, Prajwal Gyawali, Stephen Bird   +3 more
wiley   +1 more source

Kynurenine levels are elevated in patients with heart failure with reduced ejection fraction or atrial fibrillation undergoing hemodialysis. [PDF]

Med Int (Lond)
Divani M, Katsanaki A, Makri P, Poulianiti C, Lykotsetas E, Balatsouka A, Tziastoudi M, Stefanidis I, Eleftheriadis T.   +8 more
europepmc   +1 more source

Society and the Microbiome: A Biopsychosocial Window Into Comprehensive Well‐Being: A Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Objectives In addition to biological factors, human social behavior, societal structures, and environmental contexts significantly influence the human microbiome. This review examines how socially relevant factors relate to the microbiome to clarify underlying mechanisms and health impacts, aiming to inform effective preventive ...
Jing Li, Yang Yang, Yufeng Wang, Ji'An Liu, Xufeng Huang, Zhengrui Li, Ju Li   +6 more
wiley   +1 more source

Artemether and Euphorbia factor L9 suppress kynurenine production through distinct effects on tryptophan metabolism. [PDF]

Biochem J
Capatina AL, Czechowski T, Plunkett-Jones C, Tonon T, Kourtzelis I, Lichman BR, Brackenbury WJ, Graham IA, Lagos D.   +8 more
europepmc   +1 more source

A Distinct Tryptophan Metabolic Phenotype Marks Severe Fatigue in Quiescent Crohn's Disease

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background Fatigue is a common and debilitating symptom in inflammatory bowel disease (IBD), but its underlying mechanisms remain unclear. Altered tryptophan metabolism may contribute to fatigue. Tryptophan is metabolized through the kynurenine, serotonin, and indole pathway, involving host and microbial processes. We aimed to explore the link
Paula I. Metselaar, Mees J. van der Hoff, Naomi V. Wieser, Olaf Welting, Antoine Lefèvre, Camille Dupuy, Patrick Emond, Joep P. M. Derikx, Wouter J. de Jonge, Geert R. A. M. D'Haens, Anje A. te Velde, Mark Löwenberg, Mohammed Ghiboub   +12 more
wiley   +1 more source

Biochemical Regulation of Brain Kynurenic Acid Synthesis and Inhibition in Rats Is Sensitive to the Time of Day. [PDF]

ACS Chem Neurosci
Wright CJ, Buck SA, Milosavljevic S, Lewis AM, Wagner NTJ, Pocivavsek A.   +5 more
europepmc   +1 more source

Fasting and Caloric Restriction Activate an ADIOL‐NHR‐91‐Kynurenine Pathway Signaling Axis to Promote Healthspan

Aging Cell, Volume 25, Issue 5, May 2026.
The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández, Shinja Yoo, George A. Lemieux, Sena Komatsu, Abdullah Q. Latiff, Rishika R. Patil, Kaveh Ashrafi   +6 more
wiley   +1 more source