Results 151 to 160 of about 37,687 (273)

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related ...
Rachel K. Morgan, Evelyn K. Matei, Junru Pan, Tomoko Ishikawa, Katelyn M. Polemi, Ingrid Bergin, Sean P. Ferris, Hao Wang, Dana C. Dolinoy, Kelly M. Bakulski, Justin A. Colacino   +10 more
wiley   +1 more source

Kynurenin [PDF]

, 2017
openaire   +2 more sources

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

Kynurenine pathway dysregulation in attention-deficit hyperactivity disorder: Impact on N-methyl-D-aspartate receptors and phasic dopamine maturation. [PDF]

World J Clin Pediatr
Nagamine T.
europepmc   +1 more source

Music and Exercise in Concert: Uncovering Synergistic Mechanisms for Enhancing Brain Health and Cognitive Resilience—A Narrative Review

Brain and Behavior, Volume 16, Issue 9, September 2026.
Music and physical exercise share convergent neurobiological mechanisms, including neuroplasticity, metabolic regulation, and neuroinflammatory modulation. Integrating music with exercise produces synergistic effects that enhance brain function beyond single interventions.
Sanxia Yang, Qingluan Liu, Minghui Wang, Yidan Zhang   +3 more
wiley   +1 more source

Spatial Omics in High‐Grade Gliomas: Mapping Immune–Tumor Niches for Precision Therapy

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT High‐grade gliomas (HGGs), particularly glioblastoma (GBM), remain among the most lethal human cancers despite decades of molecular profiling and therapeutic innovation. A primary reason for treatment failure is that HGG biology is spatial: malignant cell states, immune suppression, metabolic stress, and therapeutic resistance are organized ...
Saniyah Shaikh, Thaabit Raziq, Sulaf B. Alfares, Touleen T. Raslan, Ismail A. Abdullah, Itika Arora, Shamsa Saleh, Mohammed Imran Khan, Ahmed Yaqinuddin   +8 more
wiley   +1 more source

Tryptophan Metabolism in Digestive and Extra-Digestive Diseases: Mechanisms, Clinical Implications, and Therapeutic Perspectives. [PDF]

Nutrients
Tohumcu E, Puca FS, Tunali V, Cerrito L, Pallozzi M, Stella L, Maestri M, Murace CA, Porcari S, Varca S, Severino A, Gasbarrini A, Ianiro G, Ponziani FR.   +13 more
europepmc   +1 more source

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Sleep Deprivation Induces Glial Dysfunction, Synaptic Loss, Metabolic Imbalance, and Cognitive Impairment in 12‐Month‐Old Mice: Protective Effects of D30

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Sleep deprivation induces neuroglial atrophy and dendritic spine loss, accompanied by metabolic disturbances involving 1‐methyladenosine, citric acid, L‐kynurenine, and berberine, indicating disrupted neuroenergetic and immunometabolic homeostasis. These alterations result in deficits in spatial recognition, fear conditioning, nesting, and Morris Water
Xueyan Liu, Huiling Lin, Jian Zhong, Xili Chen, Zonglin Wang, Meng Shi, Hang Shi, Hui Zhang, Ping Chen, Zu‐Cheng Ye   +9 more
wiley   +1 more source

Tanshinone IIA restores CD8⁺ T-cell immunity in TNBC by suppressing the IDO1-kynurenine axis. [PDF]

Front Pharmacol
Qiu Z, Meng C, Tang M.
europepmc   +1 more source