Results 141 to 150 of about 41,015 (259)

Kynurenine [PDF]

, 2020
openaire   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

microRNA‐mediated control of cell fate specification and patterning in Marchantia polymorpha

New Phytologist, Volume 252, Issue 5, Page 1943-1961, December 2026.
The gemma developmental program in Marchantia polymorpha is coordinated by MpMIR166‐mediated repression of MpC3HDZ and auxin homeostasis. Summary MicroRNAs (miRNAs) are small non‐coding RNA molecules essential for growth and development in eukaryotes. In plants, the master gene DICER‐LIKE 1 (DCL1) catalyzes the biogenesis of miRNAs by processing double‐
Adolfo Aguilar‐Cruz, Eduardo Flores‐Sandoval, Ye Xu, Yu Yu, Ximena Gutiérrez‐Ramos, Cristian Y. González‐Rangel, Omar Oltehua‐López, Ana E. Dorantes‐Acosta, Joshua T. Trujillo, Hirotaka Kato, Kimitsune Ishizaki, Rebecca A. Mosher, Liam Dolan, Xuemei Chen, Daniel Grimanelli, Jim Haseloff, John L. Bowman, Mario A. Arteaga‐Vazquez   +17 more
wiley   +1 more source

Inflammaging and Cellular Senescence in Postmenopausal Depression: Linking Estrogen Deficiency, Immune Dysregulation, and Brain Aging

The FASEB Journal, Volume 40, Issue 22, 30 November 2026.
Declining estrogen signaling may promote inflammaging and cellular senescence/SASP, which converge on blood–brain barrier disruption, glial activation, and neuroimmune dysfunction, thereby increasing vulnerability to depression after menopause. This graphical abstract presents a candidate, hypothesis‐generating model rather than an established causal ...
Lan Zhang, Yao Yao, Xiaoyu Cai
wiley   +1 more source

Increased kynurenine/tryptophan and neopterin levels in hemodialysis

, 2013
In our study, the tryptophan degradation via the kynurenine pathway and neopterin levels as markers of cellular immune activity were evaluated in hemodialysis (HD) patients in order to confirm the data of previous studies.
Hacisevki, AYSUN, Sezer, S., Ozkan, Y., Baba, B.   +3 more
core  

Longitudinal Associations Between Inflammation and Multi‐Dimensional Fatigue up to 2 Years After Colorectal Cancer Diagnosis

International Journal of Cancer, Volume 159, Issue 10, Page 2437-2451, 15 November 2026.
Cancer‐related fatigue (CRF) is a common and debilitating symptom among colorectal cancer (CRC) patients, but its underlying biological causes remain unclear, with inflammation emerging as a leading suspect. Here, researchers analyzed inflammatory biomarkers in blood samples and evaluated responses in fatigue assessments from CRC patients at and up to ...
Anouk E. C. Bruijnzeels, Floortje Mols, Katrijn Van Deun, Dounya Schoormans   +3 more
wiley   +1 more source

Metabolite-Driven Immunometabolic Crosstalk in Intervertebral Disc Degeneration: The Macrophage-Disc Cell Interface. [PDF]

J Inflamm Res
Ma D, Zhao J, Guo K, Liu W, Yin H, Zhan Y, Zhao R, Wang J, Ma T.   +8 more
europepmc   +1 more source

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

Bringing Untargeted Metabolomics to the Clinic: Real‐World Data and Implementation for Screening of Inherited Metabolic Diseases

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Inherited metabolic diseases (IMD) require timely diagnosis since a considerable number of these disorders respond to early treatment. Traditional metabolic screening relies on multiple targeted assays guided by clinical symptoms, making it laborious and potentially increasing the risk of underdiagnosis.
D. Augustijn, R. Bonte, M. C. Hagemeijer, J. Bierau, E. H. Jacobs, C. J. Klein‐de Ronde, E. van der Star, D. Y. van Haaften‐Visser, N. C. Peltenburg‐de Jong, C. Debuy, M. van Dijk, D. Vos, G. J. G. Ruijter, S. M. I. Goorden   +13 more
wiley   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source