Results 161 to 170 of about 34,126 (294)

Elucidating Immune Cell Mediated Causal Pathways Linking Blood Metabolites to Major Depressive Disorder: A Mediation Mendelian Randomization Analysis

Brain and Behavior, Volume 16, Issue 6, June 2026.
Our integrative Mendelian randomization framework revealed that specific circulating metabolites exert causal effects on major depressive disorder, partly through immune‐cell–mediated pathways. These findings highlight metabolite–immune interactions as potential mechanistic targets for MDD prevention and therapy.
Zhiwei Xu, Yining Zhou, Xuecheng Zhang, Xiaowen Chen, Yajing Li, Jintao Wang, Ting Chang, Zhen Yuan, Hongling Jia   +8 more
wiley   +1 more source

The placental tryptophan pathway across gestation: implications for pregnancy outcomes. [PDF]

Hum Reprod Update
Karahoda R, Walker D, Abad C, Anandam KY, Murthi P, Staud F.   +5 more
europepmc   +1 more source

An investigation of the kynurenine pathway in experimental arthritis

, 2011
The kynurenine pathway is a catabolic biochemical pathway responsible for degradation of tryptophan, an essential amino acid. As a consequence, biologically active molecules, kynurenines, are produced.
Williams, Richard, Paleolog, Ewa, Kolodziej, Lukasz   +2 more
core  

Sleep Traits and Cognitive Function: A Prospective Cohort Study With Exploration of Inflammatory Biomarkers

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Introduction Although sleep disturbance is closely linked to cognitive impairment, the specific sleep‐related characteristics driving this deficit remain undetermined, with the mechanistic contribution of biomarkers also poorly characterized.
Chi Peng, Fan Yang, Fanfan Li, Ronghui Zhu, Lei Li, Zhentao Zhang, Jianyao You, Rui Wang, Yingyi Qin, Shuogui Xu   +9 more
wiley   +1 more source

Rice Bran Arabinoxylan Compound and Tryptophan Metabolism on Quality of Life of Cancer Patients: A Secondary Analysis of the RBAC-QoL Study. [PDF]

Int J Tryptophan Res
Ooi SL, Kimble B, Pak BS, Micalos PS, Pak SC.   +4 more
europepmc   +1 more source

Gut Microbiome–Sleep Crosstalk: Mechanistic Pathways, Dysbiosis Signatures, and Microbiome‐Based Interventions

Brain and Behavior, Volume 16, Issue 6, June 2026.
Gut dysbiosis and sleep disturbances interact bidirectionally through microbial metabolites, immune activation, and neuroendocrine signaling along the gut–brain axis. Microbiome‐based interventions, including probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation, may help improve sleep quality and reduce inflammatory ...
Ghaleb Oriquat, Shaker Al‐Hasnaawei, Hayjaa Mohaisen Mousa, Malathi H, Siya Singla, Samir Sahoo, Vimal Arora, Ashish Singh Chauhan, Mehrdad Nourizadeh   +8 more
wiley   +1 more source

Kynurenine levels are elevated in patients with heart failure with reduced ejection fraction or atrial fibrillation undergoing hemodialysis. [PDF]

Med Int (Lond)
Divani M, Katsanaki A, Makri P, Poulianiti C, Lykotsetas E, Balatsouka A, Tziastoudi M, Stefanidis I, Eleftheriadis T.   +8 more
europepmc   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Biochemical and Pharmacological Studies on Kynurenic Acid Metabolism in the <i>Helix pomatia</i>-Snail Model of Learning and Memory. [PDF]

Biomolecules
Baran H, Kronsteiner C.
europepmc   +1 more source

Fecal Microbiota Transplantation From Patients With Social Anxiety Disorder Is Associated With General Anxiety‐Like Behavior and Gut Microbiota Alterations in Mice

Brain and Behavior, Volume 16, Issue 6, June 2026.
Fecal microbiota transplantation from patients with social anxiety disorder (SAD) into mice induces anxiety‐like behaviors, accompanied by gut microbiota alterations (increased Bacteroidota, decreased butyrate producers), downregulation of microbial metabolic pathways, and reduced plasma tryptophan, suggesting a causal role of gut dysbiosis in SAD ...
Yu‐Chao Feng, Xiao‐Xuan Liu, Huan Yu, Rui Liu, Ting‐Song Pang, Hua‐Ning Wang, Zheng‐Wu Peng   +6 more
wiley   +1 more source