Results 161 to 170 of about 47,432 (263)

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source

Nexus of IDO1/Kynurenine Pathway to T-Cell Exhaustion: Hypoxia-Induced Tryptophan Metabolism in Glioblastoma. [PDF]

Metabolites
Abikenari M, Nageeb G, Ha JH, Sjoholm MA, Liu J, Bergsneider B, Valenzuela J, Poe J, Bog Cho K, Verma R, Wu C, Sanker V, Medikonda R, Kim LH, Choi J, Banu MA, Lim M.   +16 more
europepmc   +1 more source

Stage‐Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune‐Related Involvement in Bladder Cancer Progression

International Journal of Urology, Volume 33, Issue 5, May 2026.
ABSTRACT L‐tryptophan (Trp) metabolism through the L‐kynurenine (Kyn) pathway contributes to immune escape in neoplasms, including bladder cancer (BC). Indoleamine 2,3‐dioxygenase‐1 (IDO1) is a key enzyme, and its catabolites—Kyn, 3‐hydroxykynurenine (3HK), and 3‐hydroxyanthranilate (3HAA)—depend on other enzymes and play a crucial role in ...
Douglas Edgard Lemes, Aline Áurea de Souza Santos, Jéssica Lopes de Oliveira, Henrique Roman‐Ramos, Ana Carolina Ramos Moreno, Cleber Pinto Camacho, José Pontes‐Junior, Humberto Dellê   +7 more
wiley   +1 more source

KYNURENINE TRANSAMINASE FROM NEUROSPORA

Journal of Biological Chemistry, 1956
D M, BONNER, W B, JAKOBY
openaire   +2 more sources

Periodontal inflammation and tryptophan-kynurenine metabolism in Parkinson's disease. [PDF]

Clin Oral Investig
Yilmaz M, Bakici A, Parlat R, Akpinar İN, Karaaslan R, Balci N, Toygar H, Kurgan Ş, Serdar MA, Kantarcı A.   +9 more
europepmc   +1 more source

Psychobiotics and the microbiota–gut–brain axis: Emerging paradigms in mental health modulation

Experimental Physiology, Volume 111, Issue 5, Page 2449-2463, 1 May 2026.
Abstract The global rise in mental health conditions has prompted interest in interventions that act beyond conventional psychopharmacology. Psychobiotics, broadly understood as live microorganisms or microbe‐derived products that interact with the microbiota–gut–brain axis, have been suggested to exert neuroactive effects through neural, immune ...
Amir Arsalan Ghahari, Mehrdad Nourizadeh, Mehrdad SalekShahabi, Shaghayegh Davari, Saeid Mohammadzadeh Mounesyar   +4 more
wiley   +1 more source

The role of tryptophan-AhR signaling in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): implications for therapeutic strategies. [PDF]

Front Immunol
Zhao Y, Cheng S, Liang J, Yu G.
europepmc   +1 more source

Behavioral, antioxidant, and kynurenine pathway modulation of a specific strain of Ligilactobacillus salivarius in a preclinical model of depression. [PDF]

Eur J Nutr
Martín-Hernández D, Caso JR, Díaz-García C, Regidor PA, Rizo JM, Román M, Gutiérrez R, Leza JC.   +7 more
europepmc   +1 more source

Physical Activity, Metabolic Dysfunction, and the Kynurenine Pathway in Endometriosis and Polycystic Ovary Syndrome: A Literature Review. [PDF]

Biomolecules
Varga N, Kis-György R, Ajkay-Donáth L, Tapody ZI, Vágvölgyi-Sümegi E, Körtési T, Nagy-Grócz G.   +6 more
europepmc   +1 more source

Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns: A Multinational Cross-Sectional Study. [PDF]

Neurol Neuroimmunol Neuroinflamm
Kupjetz M, Langeskov-Christensen M, Riemenschneider M, Inerle S, Ligges U, Gaemelke T, Patt N, Bansi J, Gonzenbach RR, Reuter M, Rosenberger F, Meyer T, McCann A, Ueland PM, Eskildsen SF, Emil Nygaard MK, Joisten N, Hvid L, Dalgas U, Zimmer P.   +19 more
europepmc   +1 more source