Results 181 to 190 of about 34,126 (294)

Biochemical Regulation of Brain Kynurenic Acid Synthesis and Inhibition in Rats Is Sensitive to the Time of Day. [PDF]

ACS Chem Neurosci
Wright CJ, Buck SA, Milosavljevic S, Lewis AM, Wagner NTJ, Pocivavsek A.   +5 more
europepmc   +1 more source

Beyond Glycolysis: Targeting Non‐Glycolytic Metabolic Pathways in Brain Tumors for Therapeutic Innovation: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Metabolic reprogramming is a hallmark of brain tumors, extending beyond the classical Warburg effect. While glycolysis has been extensively studied, gliomas and pediatric high‐grade brain cancers demonstrate remarkable metabolic plasticity.
Iffat Islam Mayesha, Zubaier Ahmed, Ammarah Laaika Mohiuddin, Faiza Fairuz Muskan, Saiful Islam, Sharmin Jahan Sumaya   +5 more
wiley   +1 more source

Amino Acid-Fatty Acid Profile as a Novel Predictive Method in the Assessment of Diagnosis and Treatment Efficacy of Anxiety-Related Disorders and Mood Disorders. [PDF]

Int J Mol Sci
Kowalczyk M, Aebisher D, Szpara J, Czech S, Kowalczyk E, Majsterek I, Bartusik-Aebisher D, Henrykowska G.   +7 more
europepmc   +1 more source

Probiotics‐derived postbiotics improve host metabolic syndrome by activating the adipocyte thermogenic signaling pathway in high‐fat diet‐fed mice

iMetaOmics, Volume 3, Issue 2, June 2026.
This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian, Liujing Huang, Yifan Liu, Xudong Mai, Yanbo Cheng, Bingdong Liu, Yixin Chen, Liwei Xie   +7 more
wiley   +1 more source

Stage-Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune-Related Involvement in Bladder Cancer Progression. [PDF]

Int J Urol
Lemes DE, Santos AÁS, de Oliveira JL, Roman-Ramos H, Moreno ACR, Camacho CP, Pontes-Junior J, Dellê H.   +7 more
europepmc   +1 more source

Immune Evasion in Ovarian Cancer Peritoneal Metastasis: Mechanisms and Biomarker‐Guided Therapeutic Matching

Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.
This graphical abstract summarizes the major immune‐evasion mechanisms that limit immunotherapy efficacy in ovarian cancer peritoneal metastasis. Peritoneal dissemination is shaped by impaired antigen visibility, coordinated immune‐evasion modules within ascites and multicellular spheroids, checkpoint‐driven T‐cell exhaustion, suppressive tumor ...
Xiaodong Wang, Junjie Wang, Di Xiong, Songli Cui, Qianqian Wang, Yiping Huang, Gouping Ding, Yixuan Tang, Yeqian Feng   +8 more
wiley   +1 more source

Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults. [PDF]

J Transl Med
Good L, Brandão LEM, van Egmond LT, Khoonsari PE, Erngren I, Carlsson H, Fredriksson R, Kultima K, Benedict C, Cedernaes J.   +9 more
europepmc   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, Volume 63, Issue 6, Page 1509-1545, June 2026.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Systemic Oxidative and Nitrosative Stress in Benign Prostatic Hyperplasia. [PDF]

Antioxidants (Basel)
Biesiadecki M, Galiniak S, Balawender K, Połeć J, Mołoń M.   +4 more
europepmc   +1 more source

Tryptophan Metabolism and Aryl‐Hydrocarbon Receptor Agonists in the Gut Microbiome of People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The gut microbiome of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is investigated to identify changes in microbial tryptophan metabolism. We reveal a subcommunity of microbes that correlates with tryptophan metabolism that differs in structure and diversity and identify differences in stool indoles including aryl‐hydrocarbon
David J. Esteban, Brynn Conrad, Autumn Cullinan, Sharon Luong, Jason Albaum, Victoria Wilk   +5 more
wiley   +1 more source