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Immune-proteo-metabolomic changes link to Aβ and tau pathology in Alzheimer disease. [PDF]
Alzheimers DementWang M +21 more
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Kynurenines and headache [PDF]
Journal of Neural Transmission, 2011 In parallel to serotonin synthesis, the major route of tryptophan catabolism is the kynurenine pathway, which produces neuroactive metabolites. Among these substances, kynurenic acid has potential neuroprotective action blocking glutamate release and glutamatergic neurotransmission.
Párdutz Árpád +5 more
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The kynurenine system and immunoregulation [PDF]
Journal of Neural Transmission, 2011 There is developing interest in the role of the kynurenines in the immune function. A considerable amount of evidence has accumulated as concerns interactions between the kynurenine pathway, cytokines and the nervous system. Indoleamine 2,3-dioxygenase (IDO) occupies a key position connecting the immune system and the kynurenine pathway.
Mándi Yvette, Vécsei László
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Advances in kynurenine analysis
Clinica Chimica Acta, 2023Kynurenine, the first product of tryptophan degradation via the kynurenine pathway, has become one of the most frequently mentioned biomarkers in recent years. Its levels in the body indicate the state of the human physiology. Human serum and plasma are the main matrixes used to evaluate kynurenine levels and liquid chromatography is the dominant ...
K, Mrštná +2 more
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Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition [PDF]
Frontiers in Molecular Biosciences, 2019 The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid. Quinolinic acid (QUIN) is an excitotoxic agonist at the NMDA receptor, and has been shown to be elevated ...
Robert Phillips, J Phillip Bowen
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The Kynurenines and the Seizures
1996At present, patients with epilepsy are resistant against all antiepileptic drugs in 15–25 per cent of cases. Hence the search for new pathogenetically sound approaches to treatment of this disease. Different neuroactive substances have been studied, of them kynurenines attracting a particular attention.
V I, Guzeva +2 more
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Epilepsia, 1981
Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
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Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
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The determination of kynurenine in plasma
Clinica Chimica Acta, 1975A method is described for the estimation of kynurenine in plasma via alkaline cleavage, extraction and diazotisation and coupling. Tryptophan interference, which is demonstrated in an earlier method, has been eliminated. Data on the specificity of the present method and the normal adult male range of fasting plasma kynurenine are presented.
M H, Joseph, D, Risby
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1996
The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
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The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
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Nature, 1966
THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
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THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
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