Tryptophan's Journey Through Pregnancy: The Role of Serotonin. [PDF]
Int J Tryptophan ResGendrot B, Vaillancourt C, Fouquet G.
europepmc +1 more source
Bipolar Disorders, Volume 28, Issue 5, August 2026.ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders +21 more
wiley +1 more source
Linkage of kynurenine pathway metabolites to neuroinflammation in drug-naive children with attention-deficit/hyperactivity disorder: A cross-sectional, case-control study. [PDF]
World J Clin PediatrÜnal K +4 more
europepmc +1 more source
Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer
Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo +6 more
wiley +1 more source
The placental tryptophan pathway across gestation: implications for pregnancy outcomes. [PDF]
Hum Reprod UpdateKarahoda R +5 more
europepmc +1 more source
The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
wiley +1 more source
Rice Bran Arabinoxylan Compound and Tryptophan Metabolism on Quality of Life of Cancer Patients: A Secondary Analysis of the RBAC-QoL Study. [PDF]
Int J Tryptophan ResOoi SL +4 more
europepmc +1 more source
Human IDO2 exhibits unique binding affinities distinct to those of human IDO1
The FEBS Journal, Volume 293, Issue 15, Page 4533-4553, August 2026.Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi +8 more
wiley +1 more source
Kynurenine levels are elevated in patients with heart failure with reduced ejection fraction or atrial fibrillation undergoing hemodialysis. [PDF]
Med Int (Lond)Divani M +8 more
europepmc +1 more source