Results 101 to 110 of about 34,126 (294)
An investigation of the kynurenine pathway in experimental arthritis [PDF]
, 2012 The kynurenine pathway is a catabolic biochemical pathway responsible for degradation of tryptophan, an essential amino acid. As a consequence, biologically active molecules, kynurenines, are produced.
Kolodziej, Lukasz
core +1 more source
Integrative Zoology, EarlyView.Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu +3 more
wiley +1 more source
Development of a Fluorescent Chemosensor for the Detection of Kynurenine
, 2016 Kynurenine, a metabolite of tryptophan, is known to contribute to cancer progression when overproduced. A method for facile fluorescent sensing of kynurenine using sensor 1 has been developed.
Timothy E. Glass (536972) +1 more
core +1 more source
Sleep disturbance and kynurenine metabolism in depression [PDF]
, 2017 ObjectiveAlthough the interrelationships between sleep disturbance, inflammation, and depression have been found, molecular mechanisms that link these conditions are largely unknown.
Robert Dantzer +11 more
core +1 more source
Allergy, EarlyView.Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri +11 more
wiley +1 more source
Immunodetection of l-kynurenine in colorectal and breast tumour specimens.
, 2015 A and B, Representative micrographs of immunohistochemical stainings of paraffin-embedded healthy epithelia and colorectal or breast cancer samples using specific antibodies targeting kynurenine (clone 3D4-F2).
Valerie Velasco (5663227) +13 more
core +1 more source
Human brain matters: Navigating the neuropathology of COVID‐19
Brain Pathology, EarlyView.Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland +4 more
wiley +1 more source
Brain Pathology, EarlyView.Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma +12 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle +12 more
wiley +1 more source
Frontiers in PsychiatryDepressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská +7 more
doaj +1 more source