Results 101 to 110 of about 41,015 (259)
Administration of kynurenine depleting enzymes for tumor therapy [PDF]
, 2015 Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine.
Blazeck, John +4 more
core +1 more source
Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy
Movement Disorders, EarlyView.Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao +8 more
wiley +1 more source
Administration of kynurenine depleting enzymes for tumor therapy [PDF]
, 2014 Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine.
Georgiou, George M., Stone, Everett
core +1 more source
Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus
Pest Management Science, EarlyView.Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano +7 more
wiley +1 more source
Process for converting tryptophan into kynurenine
, 2009 A process for converting tryptophan into kynurenine. Theconversion of tryptophan into kynurenine is carried out by irradiating a substance comprising tryptophan with electromagnetic radiationcomprising waves withwavelength in the range of 10 nanometer to
Scott, E.L. +4 more
core
Phytotherapy Research, EarlyView.Amomum villosum essential oil (AVEO) alleviates LPS‐induced neuroinflammation and cognitive and behavioral dysfunction by suppressing PI3K‐Akt and MAPK signaling pathways, modulating inflammatory responses, and restoring metabolic homeostasis, thereby exerting neuroprotective effects. ABSTRACT Amomum villosum Lour.
Hongjin Wang +11 more
wiley +1 more source
Natural Glycosides in Neurodegenerative Diseases: Multi‐Target Mechanisms via the Gut–Brain Axis
Phytotherapy Research, EarlyView.Core pathological features of NDs and the mediating role of the gut_brain axis. The dysregulation of gut microbiota and intestinal barrier leakage trigger systemic inflammation, exacerbating abnormal protein aggregation (such as Aβ and α‐synuclein), oxidative stress, and neuroinflammation in the brain.
Lu Chen +5 more
wiley +1 more source
Frontiers in PhysiologyImpaired renal reserve induced by unilateral nephrectomy (UNx) leads to the full-spectrum of phenotypes of preeclampsia (PE) in mice. L-kynurenine (a product of L-tryptophan metabolism) supplementation throughout the entire pregnancy rescues the PE-like ...
Yuye Wang +5 more
doaj +1 more source
Integrative Zoology, EarlyView.Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu +3 more
wiley +1 more source