Results 81 to 90 of about 34,126 (294)

Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61‐8048 after chronic intermittent ethanol in mice

, 2022
BACKGROUND AND PURPOSE: The kynurenine pathway has been proposed as a target for modulating drug abuse. We previously demonstrated that inhibition of kynurenine 3‐monooxygenase (KMO), using Ro 61‐8048, reduces ethanol consumption in a binge drinking ...
Giménez‐Gómez, Pablo, Morales‐Puerto, Nuria, Vidal, Rebeca, Núñez-de la Calle, Carlos, Gil de Biedma‐Elduayen, Leticia, Leticia Gil de Biedma‐Elduayen, Pablo Giménez‐Gómez, Núñez De La Calle, Carlos, Gutiérrez‐López, María Dolores, Giménez-Gómez, Pablo, Giménez Gómez, Pablo, Gutiérrez-López, María Dolores, O'Shea Gaya, María Esther, Núñez‐de la Calle, Carlos, Colado Megías, María Isabel, Morales-Puerto, Nuria, Isabel Colado, Maria, Gutiérrez López, María Dolores, Carlos Núñez‐de la Calle, María Isabel Colado, Rebeca Vidal, Esther O'Shea, Nuria Morales‐Puerto, Dolores Gutierrez-Lopez, Maria, Morales Puerto, Nuria, Colado, María Isabel, Gil De Biedma Elduayen, Leticia, Gil de Biedma-Elduayen, Leticia, O'Shea, Esther, Vidal Casado, Rebeca, María Dolores Gutiérrez‐López   +30 more
core   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

A history of suicide attempts among individuals with schizophrenia is associated with tryptophan degradation via the salivary kynurenine pathway

BMC Psychiatry
Background Tryptophan, an essential precursor metabolite within the kynurenine pathway, has been implicated in the neurobiological mechanisms underlying both schizophrenia and associated suicidality. Despite this link, the lack of validated biomarkers to
Yi Yin, Ting Xie, Jinghui Tong, Junchao Huang, Baopeng Tian, Mengzhuang Gou, Song Chen, Shuping Tan, Zhiren Wang, Yongsheng Tong, Yanfang Zhou, Leilei Wang, Yunlong Tan   +12 more
doaj   +1 more source

Biocatalytic reactions, crystal structures and mechanisms of kynurenine formamidases

Tetrahedron Chem
Kynurenine (Kyn) as a non-proteinogenic amino acid, is prevalent in various bioactive natural products, and plays a pivotal role in metabolism and related diseases.
Changmei Liu, Chengyue Miao, Xiaorui Chen, Yan Zhang, Yijian Rao, Zhenbo Yuan   +5 more
doaj   +1 more source

Longitudinal Associations Between Inflammation and Multi‐Dimensional Fatigue up to 2 Years After Colorectal Cancer Diagnosis

International Journal of Cancer, EarlyView.
Cancer‐related fatigue (CRF) is a common and debilitating symptom among colorectal cancer (CRC) patients, but its underlying biological causes remain unclear, with inflammation emerging as a leading suspect. Here, researchers analyzed inflammatory biomarkers in blood samples and evaluated responses in fatigue assessments from CRC patients at and up to ...
Anouk E. C. Bruijnzeels, Floortje Mols, Katrijn Van Deun, Dounya Schoormans   +3 more
wiley   +1 more source

Tryptophan regulates the expression of IGFBP1 in bovine endometrial epithelial cells in vitro via the TDO2-AHR pathway

BMC Veterinary Research
Background This study aimed to identify the roles of L-tryptophan (Trp) and its rate-limiting enzymes on the receptivity of bovine endometrial epithelial cells. Real-time PCR was conducted to analyze the differential expression of genes between different
Peng-Chao Wang, Ze-Kun Liu, Jia-Rong Li, Zi-Hui Zhao, Qian-Wen Chang, Xiao-Min Guo, Lin Jin, Yong-Ting Hu, Zhenshan Yang   +8 more
doaj   +1 more source

Kynurenine Promotes Phosphate-Induced Endothelial Calcification via Endothelial-to-Mesenchymal Transition, Osteoblastic Differentiation and AhR Activation

Toxins
In end-stage renal disease (ESRD), the accumulation of solutes normally excreted by the kidneys contributes to multiple complications, including vascular calcification (VC), a key factor in the heightened cardiovascular risk seen in these patients. Among
Martina Molinaro, Mario Cozzolino, Paola Ciceri   +2 more
doaj   +1 more source

Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes

, 2005
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Newcombe, J, Kalina, P, Kepplinger, B, Baran, H, Ferraz-Leite, H, Kainz, A   +5 more
core  

Second‐trimester multimetabolite panel for early preeclampsia rule‐out

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective We aimed to establish a high‐sensitivity, multimetabolite rule‐out model for the development of preeclampsia (PE), prioritizing minimizing false negatives to exclude low‐risk individuals from intensive surveillance confidently. Methods In this prospective, nested case–control study, maternal serum samples were collected between 20+0 ...
Matthews Silva Martins, Julyane N. S. Kaihara, Diego Fortes Salgueiro, Viviane Cunha Cardoso, Silvana Maria Quintana, Ricardo Carvalho Cavalli, Valerio Garrone Barauna, Valeria Cristina Sandrim   +7 more
wiley   +1 more source

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

iMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin, Cui Zhang, He‐Hua Lei, Zheng Cao, Xin Gao, Wen‐Kai Yu, Xin‐Zhi Li, Qing‐Wei Xiang, Zhi‐Wen Zhang, Shi‐Fu Pang, Wei‐Fei Luo, Deng‐Hui Xie, Li‐Min Zhang, Gang Chen   +13 more
wiley   +1 more source