Results 61 to 70 of about 34,126 (294)
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source
Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Brain injury and neurological deficit are consequences of cardiac arrest (CA), leading to high morbidity and mortality. Peripheral activation of the kynurenine pathway (KP), the main catabolic route of tryptophan metabolized at first into ...
Jacopo Lucchetti +15 more
doaj +1 more source
Importance of kynurenine in pulmonary hypertension
, 2017 The tryptophan metabolite kynurenine is significantly increased in pulmonary arterial hypertension (PAH) patients, and it is a potent vasodilator of systemic arteries. Our aim was to investigate the role of kynurenine in the pulmonary circulation. Serum
Bence M. Nagy +13 more
core +1 more source
Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients
British Journal of Clinical Pharmacology, EarlyView.Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim +37 more
wiley +1 more source
Pteridines, 2021 The aim of this study was to investigate the changes in circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during the course of chemoradiation in patients with cervical cancer.
Pospíšková Markéta +5 more
doaj +1 more source
Altered Kynurenine Pathway Metabolism in Rats Fed Added Sugars
Genel Tıp Dergisi, 2022 Aim: The consumption of added sugars containing fructose has increased dramatically. Various studies have revealed that added sugar consumption may be involved in the pathogenesis of cardiovascular, metabolic and neurocognitive disorders by triggering ...
Bahadir Ozturk, Duygu Eryavuz Onmaz
doaj +1 more source
BMEMat, EarlyView.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
Kynurenines, neurodegeneration and Alzheimer’s disease [PDF]
Journal of Cellular and Molecular Medicine, 2010 Abstract Alzheimer’s disease The kynurenine pathway Relations of kynurenines to the pathomechanism of AD A future therapeutic approach: modulating the kynurenine pathway Concluding remarks Alzheimer’s disease (AD) is one of the major causes of dementia. The pathogenesis of the disease is not entirely understood, but the amyloid β peptide (Aβ) and the
Kincses Zsigmond Tamás +2 more
openaire +4 more sources
The kynurenine pathway in major depressive disorder
, 2023 Major depressive disorder (MDD) is a serious psychiatric disorder, affecting over 264 million people globally. Despite its devastating and widespread burden, our current understanding of MDD neurobiology is limited.
Samara Brown (10722147)
core
BMEMat, EarlyView.ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning +10 more
wiley +1 more source