Results 71 to 80 of about 34,126 (294)

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma

Frontiers in Oncology, 2020
Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites
Soudabeh Rad Pour, Hiromasa Morikawa, Narsis A. Kiani, Narsis A. Kiani, David Gomez-Cabrero, David Gomez-Cabrero, Alistair Hayes, Xiaozhong Zheng, Maria Pernemalm, Janne Lehtiö, Damian J. Mole, Johan Hansson, Johan Hansson, Hanna Eriksson, Hanna Eriksson, Jesper Tegnér, Jesper Tegnér, Jesper Tegnér   +17 more
doaj   +1 more source

Alzheimer’s Disease, Astrocytes and Kynurenines [PDF]

Current Alzheimer Research, 2015
Alzheimer's disease (AD) is an age-related neurodegenerative disease and the most common cause of dementia. The etiology of AD is not entirely clear and despite the increasing knowledge regarding the pathomechanism, no effective disease-modifying therapy is yet available.
Dézsi Livia, Tuka Bernadett, Martos Diána, Vécsei László   +3 more
openaire   +4 more sources

Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur, Jashvant D. Unadkat, Emily E. Fay, Nina Isoherranen, Mary F. Hebert   +4 more
wiley   +1 more source

Impact of Plasma Kynurenine Level on Functional Capacity and Outcome in Heart Failure　- Results From Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF).

, 2016
BACKGROUND Kynurenine is a circulating metabolite from the essential amino acid tryptophan. Accelerated degradation of kynurenine in skeletal muscle has been reported to provide an anti-inflammatory effect. The aim of this study was to investigate the
Springer, Jochen, Schefold, Joerg C., von Haehling, Stephan, Ebner, Nicole, Doehner, Wolfram, Dschietzig, Thomas Bernd, Anker, Stefan D, Konishi, Masaaki, Anker, Stefan D.   +8 more
core   +1 more source

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

Drug Testing and Analysis, EarlyView.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Determination of kynurenine-3-hydroxylase

, 1969
Determination of kynurenine-3 ...
Cassady, W. E., W. E. Cassady, Wagner, R. P., R. P. Wagner   +3 more
core   +1 more source

Three data sets: IFN-γ EV kynurenine content, IFN-γ CCM kynurenine content, and the IFN-γ EV particle count.

, 2020
Three data sets: IFN-γ EV kynurenine content, IFN-γ CCM kynurenine content, and the IFN-γ EV particle count.
Tomoyoshi Soga (80283), Yusuke Yamamoto (4594909), Juntaro Matsuzaki (296866), Masahiro Sugimoto (65573), Takahiro Ochiya (32682), Ryuhei Kudo (8697852), Yusuke Yoshioka (130321), Hiroko Tadokoro (8697849), Akiyoshi Hirayama (446766), Masako Hasebe (8697855)   +9 more
core   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

The kynurenine pathway in patients with rheumatoid arthritis during tumor necrosis factor α inhibitors treatment

Objectives The importance of the kynurenine pathway in normal immune system function has led to an appreciation of its possible contribution to autoimmune disorders such as rheumatoid arthritis (RA).
Dorota Sikorska, Rafał Rutkowski, Joanna Witoszyńska-Sobkowiak, Iwona Żychowska, Karolina Niklas, Włodzimierz Samborski   +5 more
core   +1 more source

Simplified schematic of the kynurenine pathway (KP).

, 2013
IDO-1, indoleamine dioxygenase; TDO, tryptophan dioxygenase; AFMID, arylformamidase; KAT 1–3, kynurenine amino transferase 1, 2 and 3; KMO, kynurenine 3-hydroxylase; KYNU, kynureninase; 3HAAO, 3-hydroxyanthranilic acid oxidase; ACMSD, amino ...
Chai K. Lim (404939), Li Wen (169316), Roger Stankovic (404937), Wei Wu (27708), Joseph A. Nicolazzo (404936), Shisan S. Bao (404938), Bruce J. Brew (220334), Karen M. Cullen (261732), Gilles J. Guillemin (133306), Roger Chung (236272)   +9 more
core   +1 more source