Results 71 to 80 of about 41,015 (259)

Three data sets: IFN-γ EV kynurenine content, IFN-γ CCM kynurenine content, and the IFN-γ EV particle count.

, 2020
Three data sets: IFN-γ EV kynurenine content, IFN-γ CCM kynurenine content, and the IFN-γ EV particle count.
Tomoyoshi Soga (80283), Yusuke Yamamoto (4594909), Juntaro Matsuzaki (296866), Masahiro Sugimoto (65573), Takahiro Ochiya (32682), Ryuhei Kudo (8697852), Yusuke Yoshioka (130321), Hiroko Tadokoro (8697849), Akiyoshi Hirayama (446766), Masako Hasebe (8697855)   +9 more
core   +1 more source

Metabolomic investigation of cisplatin‐induced acute kidney injury in paediatric cancer patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Cisplatin causes acute kidney injury (AKI) in approximately 46% of paediatric cancer patients who receive it. Serum creatinine (SCr) is a poor biomarker of cisplatin nephrotoxicity, because there is a delay between cisplatin infusion and SCr elevation.
Yong Jin Lim, Amy Thachil, Kelly McMahon, Ross T. Tsuyuki, S. Rod Rassekh, Lesley G. Mitchell, Prasad Devarajan, Cherry Mammen, Bruce C. Carleton, Geoffrey D. E. Cuvelier, Victor A. Lewis, Colin J. D. Ross, Alexandra P. Zorzi, Sylvain Baruchel, Raveena Ramphal, Eric Bouffet, Mathieu Lemaire, Tom D. Blydt‐Hansen, Brad L. Urquhart, The Applying Biomarkers to Minimize Long‐Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group, Tom Blydt‐Hansen, Bruce C. Carleton, Geoff D. E. Cuvelier, Sunil Desai, Prasad Devarajan, Conrad Fernandez, Adam Fleming, Paul Gibson, Caroline Laverdiere, Victor Lewis, Mary L. McBride, Bruno Michon, Shahrad Rod Rassekh, Colin J. D. Ross, Christine Sabapathy, Kirk R. Schultz, Michael Zappitelli, Alexandra Zorzi   +37 more
wiley   +1 more source

Importance of kynurenine in pulmonary hypertension

, 2017
The tryptophan metabolite kynurenine is significantly increased in pulmonary arterial hypertension (PAH) patients, and it is a potent vasodilator of systemic arteries. Our aim was to investigate the role of kynurenine in the pulmonary circulation. Serum
Bence M. Nagy, Rita Papp, Gabor Kovacs, Grazyna Kwapiszewska, Walter Klepetko, Harald Mangge, Horst Olschewski, Vasile Foris, Chandran Nagaraj, Neha Sharma, Bahil Ghanim, Thomas R. Pieber, Andreas Meinitzer, Andrea Olschewski   +13 more
core   +1 more source

Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

European Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Csanova A., Jezova D.
doaj   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source

Chiral Gold Nanofibers as Substrates Toward SERS‐Based Chiral and Flexible Sensing

Chemistry – A European Journal, EarlyView.
High‐aspect‐ratio chiral gold nanofibers are a recently reported low‐dimensional material with intrinsic chiroptical properties. Here, we use them as label‐free SERS substrates for the identification of enantiomers in mixtures and detection of model compounds on the surface of paper chip‐based platforms.
Mathias R. S. Nielsen, Christian Hirsch, Gohar Soufi, Anja Boisen, Miguel A. Ramos Docampo   +4 more
wiley   +1 more source

Improving the Sensitivity in Chiral Analysis by Capillary Electrophoresis

ELECTROPHORESIS, EarlyView.
Most recent advances for the enhancement of sensitivity in capillary electrophoresis, including off‐line and in‐capillary preconcentration techniques and their combinations, and the use of alternative detection systems to UV–Vis spectrophotometric absorption.
María Castro‐Puyana, Sandra Salido‐Fortuna, María Luisa Marina   +2 more
wiley   +1 more source

Overview of the tryptophan metabolism and the kynurenine pathway.

, 2015
IDO-1: Indoleamine 2,3-dioxygenase 1. IDO-2: Indoleamine 2,3-dioxygnease 2. TDO2: Tryptophan 2,3-dioxygenase. KATs: Kynurenine amino transferases. KMO: Kynurenine-3-monooxygenase. KYNU: Kynureninase.
Valerie Velasco (5663227), Georges C. Prendergast (725118), Francesca Fallarino (725113), Gilles J. Guillemin (133306), Isabelle Soubeyran (515223), Gaetan MacGrogan (5663224), Marc Veldhoen (725117), Dominique Bodet (725116), Marc Debled (725115), Michael Platten (34815), Alban Bessede (725119), Sandrine Eimer (128039), Paolo Puccetti (432818), Antoine Italiano (725114)   +13 more
core   +1 more source