Results 91 to 100 of about 41,015 (259)

Immunodetection of l-kynurenine in colorectal and breast tumour specimens.

, 2015
A and B, Representative micrographs of immunohistochemical stainings of paraffin-embedded healthy epithelia and colorectal or breast cancer samples using specific antibodies targeting kynurenine (clone 3D4-F2).
Valerie Velasco (5663227), Georges C. Prendergast (725118), Francesca Fallarino (725113), Gilles J. Guillemin (133306), Isabelle Soubeyran (515223), Gaetan MacGrogan (5663224), Marc Veldhoen (725117), Dominique Bodet (725116), Marc Debled (725115), Michael Platten (34815), Alban Bessede (725119), Sandrine Eimer (128039), Paolo Puccetti (432818), Antoine Italiano (725114)   +13 more
core   +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Schematic representation of the kynurenine pathway.

, 2016
IDO1, indoleamine 2,3-dioxygenase 1; IDO2, indoleamine 2,3-dioxygenase 2; TDO2, tryptophan 2,3-dioxygenase; TPH1, Tryptophan hydroxylase 1; TPH2, Tryptophan hydroxylase 2; AFMID, arylformamidase; KMO, kynurenine 3-monooxygenase; CCBL1, kynurenine ...
Benjamin Hennart (205379), Loïc Yengo (160556), Gilles J. Guillemin (133306), Violeta Raverdy (3165681), Hélène Verkindt (3165666), Audrey Leloire (205385), Marie Pigeyre (3165678), Odile Poulain-Godefroy (154088), Marie Favennec (3165672), Delphine Allorge (205394), Marie Verbanck (3165675), Robert Caiazzo (3165669), François Pattou (145757), Philippe Froguel (2247)   +13 more
core   +1 more source

Neopterin, tryptophan and kynurenine as biomarkers in glioblastoma

Scientific Reports
Glioblastoma (GBM) is a highly aggressive brain tumor with limited prognostic markers to predict patient outcomes reliably. This study investigates the perioperative levels of tryptophan, kynurenine, and neopterin in patients with GBM to assess their ...
Petr Krupa, Lenka Kujovska Krcmova, Marketa Krupova, Katerina Matousová, Simona Paulikova, Petra Kasparova, Bohuslav Melichar, Tomas Cesak   +7 more
doaj   +1 more source

Lactobacillus johnsonii attenuates ovarian aging by remodeling the gut–ovary axis

iMetaOmics, EarlyView.
Aging is accompanied by a reduced abundance of L. johnsonii and ovarian decline. Supplementation with L. johnsonii elevates microbial IPA production via the LdhA enzyme and commensal bacteria. IPA activates the AhR/YAP signaling axis, promoting YAP nuclear translocation and inducing the expression of downstream target genes CYR61 and CTGF. This cascade
Jiamin He, Qiwen Wang, Luyi Chen, Yadong Qi, Dingjiacheng Jia, Jilei Xu, Qingyi Wang, Yao Jiang, Jian Zhou, Yong Sun, Ruochen Yan, Lan Wang, Tongyao Hou, Zheng Kuang, Min Jin, Liangjing Wang, Shujie Chen   +16 more
wiley   +1 more source

Mechanism of increases inl-kynurenine and quinolinic acid in renal insufficiency

, 2000
Marked increases in metabolites of thel-tryptophan-kynurenine pathway, l-kynurenine and quinolinic acid (Quin), were observed in serum and cerebrospinal fluid (CSF) of both the rat and human with renal insufficiency.
Hidehiko Fujii, Melvyn P. Heyes, Akio Noma, Kuniaki Saito, Mitsuru Seishima, Katsumi Shibata, Hisayasu Wada, Suwako Fujigaki, Masao Takemura   +8 more
core   +1 more source

Kynurenine mediates the chemotherapy-induced intestinal toxicity through modulation of gut microbiota

Nature Communications
Chemotherapy-induced intestinal toxicity is a major dose-limiting complication, but the underlying mechanisms linking systemic metabolism to localized gut damage are poorly understood.
Hongyu Xie, Jingyi Yang, Jinjie Wu, Wenhao Ma, Haoyang Xu, Shuang Guo, Yanchun Xie, Zhanhao Luo, Dayi Liang, Mujia Cao, Danling Liu, Sanqing Jin, Ping Lan, Zhen He   +13 more
doaj   +1 more source

The Kynurenine pathway in pancreatic carcinoma

, 2017
IntroductionPancreatic carcinoma (PC) belongs to the most aggressive tumours worldwide, with a five year survival of 7%. Mostly, diagnosis is made in late stages, as by now no early detection method is available.
A. Baranyi, C. Blesl, A. Meinitzer, A. Holl, A. Painold, A. Tmava, H.P. Kapfhammer, S. Mörkl, V. Stadlbauer-Köllner   +8 more
core   +1 more source

Tryptophan regulates the expression of IGFBP1 in bovine endometrial epithelial cells in vitro via the TDO2-AHR pathway

BMC Veterinary Research
Background This study aimed to identify the roles of L-tryptophan (Trp) and its rate-limiting enzymes on the receptivity of bovine endometrial epithelial cells. Real-time PCR was conducted to analyze the differential expression of genes between different
Peng-Chao Wang, Ze-Kun Liu, Jia-Rong Li, Zi-Hui Zhao, Qian-Wen Chang, Xiao-Min Guo, Lin Jin, Yong-Ting Hu, Zhenshan Yang   +8 more
doaj   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source