Results 91 to 100 of about 28,282 (229)

KYNU in Gastric Cancer Cells Promotes Tumor Progression by Influencing Macrophage Polarization Via PF4

Cancer Science, EarlyView.
KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Xilun Cui, Changfeng Li, Yuanda Liu, Chang Liu, Wei Yang   +4 more
wiley   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

THE TRANSAMINATION OF KYNURENINE

Journal of Biological Chemistry, 1953
I L, MILLER, M, TSUCHIDA, E A, ADELBERG
openaire   +2 more sources

Indoleamine 2,3‐Dioxygenase 1 as an Adjunctive Histopathological Marker of Cholangitis Activity in Primary Biliary Cholangitis

Hepatology Research, EarlyView.
IDO‐1 immunostaining identifies primary biliary cholangitis even in morphologically subtle bile duct lesions. IDO‐1 expression reflects cholangitis activity and is suppressed by ursodeoxycholic acid treatment, indicating its value as a dynamic diagnostic adjunct rather than a static marker of chronic damage.
Kaori Yoshimura, Shinji Shimoda, Ryoka Masuda, Tram Nguyen Thi, Rui Yang, Quynh Nguyen Thi, Dong Le Thanh, Yuko Tamano, Yasunori Sato, Taro Yamashita, Kenichi Harada   +10 more
wiley   +1 more source

Urinary kynurenine,tryptophan, and neopterin concentrations during physiological pregnancy

Scientific Reports
During pregnancy the alterations of kynurenine and tryptophan metabolism play an important role in local signalling and the prevention of fetal rejection.
Lenka Kujovská Krčmová, Kateřina Matoušová, Lenka Javorská, Kristýna Mrštná, Nikola Přívratská, Chaweewan Suwanvecho, Dorota Turoňová, Mohamed Farrag, Marian Kacerovský, Bohuslav Melichar   +9 more
doaj   +1 more source

Effects of repeated exposure to ozonated water on hair fibre structure and integrity: Part I

International Journal of Cosmetic Science, EarlyView.
Repeated exposure to ozonated water caused cumulative oxidative changes in hair, altering structural integrity, thermal behaviour and mechanical properties. The findings reveal a distinct ozone‐induced damage profile that progresses beyond the cuticle, challenging claims of hair‐revitalizing benefits. Abstract Objective Ozone has recently been marketed
Pedro Augusto Laurindo Igreja Marrafa, Shamish Ganpule, Vanessa Castro‐Haly, Adriana Barrinha Fernandes, Ernesta Malinauskyte, Carlos Jose de Lima   +5 more
wiley   +1 more source

Synchronous spectrofluorimetric determination of tryptophan and kynurenine in human plasma using hydroxypropyl-β-cyclodextrin complexation for investigating their role in major depressive disorder

Scientific Reports
Major depressive disorder (MDD) is recently associated with immunological activation and deregulation of the kynurenine pathway, which redirects tryptophan metabolism away from serotonin production and towards neuroactive metabolites.
Adnan Alharbi, Maram H. Abduljabbar, Reem M. Alnemari, Ahmed H. Abdelazim, Atiah H. Almalki   +4 more
doaj   +1 more source

Kynurenine monooxygenase BcKMOL: a key regulator of growth, pathogenicity, and disease control in Botrytis cinerea

Frontiers in Microbiology
Kynurenine monooxygenase, a vital rate-limiting enzyme in the kynurenine pathway metabolic branch, has shown promise as a drug target for treating human neurodegenerative diseases.
Bai Li, Bai Li, Xiaoying Liu, Jinping Zang, Hongzhe Cao, Helong Si, Kang Zhang, Kang Zhang, Jihong Xing, Jihong Xing, Jingao Dong, Jingao Dong   +11 more
doaj   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, EarlyView.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source