Results 111 to 120 of about 41,015 (259)

Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions

Molecular Pain
Chronic pain is a debilitating symptom with a significant negative impact on the quality of life and socioeconomic status, particularly among adults and the elderly.
Ebrahim Hazrati, Seyed Parsa Eftekhar, Reza Mosaed, Saeed Shiralizadeh Dini, Mehrshad Namazi   +4 more
doaj   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

The role of the kynurenine pathway in the pathogenesis of pain and affective disorders after traumatic brain injury

Brain, Behavior, & Immunity - Health
Traumatic brain injury (TBI) alters neuroimmune physiology resulting in an imbalance between pro- and anti-inflammatory cascades. Whereas acute inflammation serves as an adaptive defense mechanism of the innate immune system to promote healing and ...
Itzick Nahmoud, Karli Monahan, Eric A. Woodcock, Alana C. Conti   +3 more
doaj   +1 more source

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

Updates in acute graft‐versus‐host disease: From novel pathogenic mechanisms to emerging therapeutic targets

British Journal of Haematology, EarlyView.
The graphical abstract provides a view on selected aspects of the pathogenesis, risk stratification and treatment of acute GVHD. Summary Acute graft‐versus‐host disease (aGVHD) remains a major complication following allogeneic haematopoietic stem cell transplantation (allo‐HSCT), representing a leading cause of non‐relapse mortality (NRM) and ...
Hazim Khatib, Robert Zeiser
wiley   +1 more source

Plasma kynurenine and related measures in tic disorder patients

, 2007
Objective Increased plasma kynurenine has been reported in tic disorder patients, and this observation has been suggested to be indicative of immune dysregulation.
Ruud B. Minderaa, Cees G. M. Kallenberg, George M. Anderson, Hoekstra, Pieter J., Anderson, George M., Kallenberg, Cees G. M., Minderaa, Ruud B., Pieter W. Troost, Troost, Pieter W., Pieter J. Hoekstra   +9 more
core   +1 more source

Metabolic‐Epigenetic Coupling in Aortic Aneurysm and Aortic Dissection: GLS1 and SLC1A5 as Guardians of VSMC Homeostasis

iNew Medicine, EarlyView.
Yu Zeng, Jifeng Zhang, Haocheng Lu
wiley   +1 more source

Effects of lifelong sulforaphane intake on behavioural, neurochemical and biomolecular dysfunctions in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders

British Journal of Pharmacology, EarlyView.
Created in BioRender. Schiavone, S. (2026). https://BioRender.com/cy0xq6z. Abstract Background and Purpose Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods.
Vladyslav Sikora, Maria Bove, Lisa Pia Agosti, Rossella Pia Palmieri, Mohsin Zafar, Paolo Tucci, Maria Grazia Morgese, Stefania Schiavone, Luigia Trabace   +8 more
wiley   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Kynurenine monooxygenase BcKMOL: a key regulator of growth, pathogenicity, and disease control in Botrytis cinerea

Frontiers in Microbiology
Kynurenine monooxygenase, a vital rate-limiting enzyme in the kynurenine pathway metabolic branch, has shown promise as a drug target for treating human neurodegenerative diseases.
Bai Li, Bai Li, Xiaoying Liu, Jinping Zang, Hongzhe Cao, Helong Si, Kang Zhang, Kang Zhang, Jihong Xing, Jihong Xing, Jingao Dong, Jingao Dong   +11 more
doaj   +1 more source