Results 131 to 140 of about 41,015 (259)

The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases

Journal of Periodontal Research, EarlyView.
This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur, Kinga Grzech‐Leśniak, Samuel F. Suslavich, Janina Golob Deeb   +3 more
wiley   +1 more source

ALTERATION IN THE CONVULSIVE EFFECT OF KYNURENINE, CORAZOL AND CAFFEINE UNDER THE ACTION OF BICUCULLINE [PDF]

, 2019
In male mice of two strains SHR and C57BL/6, pretreatment with bicuculline (1 mg/kg, s.c.), an antagonist of GABA-A receptors,potentially the convulsant effect of pentylenetetrazole (40mg/kg,ip.) and caffeine (200mg/kg ip.) and had no
Niyazmetov, Baxodir Allaberganovich, Mirzayev, Saidmaxmud   +1 more
core  

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, Volume 138, Issue 45, 2 November 2026.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

Inhibition studies of kynurenine 3-monooxygenase [PDF]

, 2013
Kynurenine 3-monooxygenase (K3MO) lies on the kynurenine pathway, the major pathway for the catabolism of L-tryptophan. It converts kynurenine to 3-hydroxy kynurenine. Inhibition of K3MO is important in several neurological diseases and there is evidence
Milne, Gavin D. S.
core