Results 251 to 260 of about 34,126 (294)
Some of the next articles are maybe not open access.
Advances in kynurenine analysis
Clinica Chimica Acta, 2023Kynurenine, the first product of tryptophan degradation via the kynurenine pathway, has become one of the most frequently mentioned biomarkers in recent years. Its levels in the body indicate the state of the human physiology. Human serum and plasma are the main matrixes used to evaluate kynurenine levels and liquid chromatography is the dominant ...
František Svec
exaly +3 more sources
Kynurenines and headache [PDF]
Journal of Neural Transmission, 2011 In parallel to serotonin synthesis, the major route of tryptophan catabolism is the kynurenine pathway, which produces neuroactive metabolites. Among these substances, kynurenic acid has potential neuroprotective action blocking glutamate release and glutamatergic neurotransmission.
Párdutz Árpád +5 more
openaire +3 more sources
The Kynurenines and the Seizures
1996At present, patients with epilepsy are resistant against all antiepileptic drugs in 15–25 per cent of cases. Hence the search for new pathogenetically sound approaches to treatment of this disease. Different neuroactive substances have been studied, of them kynurenines attracting a particular attention.
V I, Guzeva +2 more
openaire +2 more sources
Epilepsia, 1981
Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
openaire +2 more sources
Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
openaire +2 more sources
The determination of kynurenine in plasma
Clinica Chimica Acta, 1975A method is described for the estimation of kynurenine in plasma via alkaline cleavage, extraction and diazotisation and coupling. Tryptophan interference, which is demonstrated in an earlier method, has been eliminated. Data on the specificity of the present method and the normal adult male range of fasting plasma kynurenine are presented.
M H, Joseph, D, Risby
openaire +2 more sources
1996
The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
openaire +2 more sources
The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
openaire +2 more sources
Nature, 1966
THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
openaire +2 more sources
THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
openaire +2 more sources
Measurement of Rat Brain Kynurenine Aminotransferase at Physiological Kynurenine Concentrations
Journal of Neurochemistry, 1991AbstractThe production of the neuroinhibitory and neuroprotective metabolite kynurenic acid (KYNA) was investigated in rat brain by examining its biosynthetic enzyme, kynurenine aminotransferase (KAT). By using physiological (low micromolar) concentrations of the substrate L‐kynurenine (KYN) and by determining the irreversible conversion of [3H] KYN to
E, Okuno +4 more
openaire +2 more sources
Binding of kynurenine to catecholamine
Amino Acids, 1992Papiliochrome II is a pale yellow pigment of butterflies and consists of one molecule each ofL-kynurenine and N-β-alanyldopamine (NBAD). The aromatic amino nitrogen of kynurenine is bonded to theβ-carbon of NBAD. There are isomers IIa and IIb which show opposite circular dichroism.
openaire +2 more sources
Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase
European Journal of Medicinal Chemistry, 1996Abstract The structural requirements of the catalytic site of kynurenine aminotransferase (KAT), the enzyme responsible for the conversion of l -kynurenine (KYN) to kynurenic acid (KYNA), were examined using analogs and derivatives of KYN. KYNA production from KYN was monitored in rat brain homogenates and brain tissue slices.
M Varasi +7 more
openaire +1 more source