Physicochemical Characterization of Kynurenine Pathway Metabolites [PDF]
AntioxidantsThe kynurenine pathway is a significant metabolic route involved in the catabolism of tryptophan, producing various bioactive metabolites with crucial roles as antioxidants in immune regulation and neurobiology.
Luca Buzásy +7 more
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A history of suicide attempts among individuals with schizophrenia is associated with tryptophan degradation via the salivary kynurenine pathway [PDF]
BMC PsychiatryBackground Tryptophan, an essential precursor metabolite within the kynurenine pathway, has been implicated in the neurobiological mechanisms underlying both schizophrenia and associated suicidality. Despite this link, the lack of validated biomarkers to
Yi Yin +12 more
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Altered Kynurenine Pathway Metabolism in Rats Fed Added Sugars
Genel Tıp Dergisi, 2022 Aim: The consumption of added sugars containing fructose has increased dramatically. Various studies have revealed that added sugar consumption may be involved in the pathogenesis of cardiovascular, metabolic and neurocognitive disorders by triggering ...
Bahadir Ozturk, Duygu Eryavuz Onmaz
doaj +3 more sources
Tryptophan-kynurenine pathway: a possible new mechanism for the prevention and treatment of reproductive system-related diseases [PDF]
PeerJTryptophan (Trp) is one of the essential amino acids, and its metabolic pathway is essential for the maintenance of normal human physiological activities.
Zhongkai Ou +4 more
doaj +3 more sources
Serum Kynurenine Pathway Metabolites as Candidate Diagnostic Biomarkers for Pituitary Adenoma: A Case–Control Study [PDF]
MedicinaBackground and Objectives: Pituitary adenomas are common intracranial tumors lacking specific non-invasive biomarkers. This study aimed to determine whether key metabolites and enzymes of the kynurenine pathway—including indoleamine 2,3-dioxygenase (IDO),
Nur Düzen Oflas +3 more
doaj +2 more sources
The Kynurenine Pathway and Indole Pathway in Tryptophan Metabolism Influence Tumor Progression [PDF]
Cancer MedicineTryptophan (Trp), an essential amino acid, is solely acquired through dietary intake. It is vital for protein biosynthesis and acts as a precursor for numerous key bioactive compounds.
Zhanhui Lu +5 more
doaj +2 more sources
The kynurenine pathway of tryptophan catabolism and schizophrenia [PDF]
Medicinski Podmladak, 2023 The development of new therapeutic options focused on the recovery of patients with schizophrenia is primarily conditioned by elucidating the biological underpinnings of the disorder.
Marković Miloš +2 more
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The kynurenine pathway in Alzheimer’s disease: a meta-analysis of central and peripheral levels [PDF]
Brazilian Journal of Psychiatry, 2023 Objective: Changes in the kynurenine pathway are recognized in psychiatric disorders, but their role in Alzheimer’s disease (AD) is less clear. We aimed to conduct a systematic review and meta-analysis to determine whether tryptophan and kynurenine ...
Brisa S. Fernandes +4 more
doaj +1 more source
Targeting the Kynurenine Pathway: A Novel Approach in Tumor Therapy. [PDF]
Expert Rev Mol MedLin S +5 more
europepmc +3 more sources
Linking major depressive disorder pathogenesis with kynurenine pathway - a literature review
Journal of Education, Health and Sport, 2023 Introduction: Depressive disorders are a significant problem. They lead to suffering, loss of interest and may contribute to suicide attempts. Despite the large number of available medications, 10-35% of patients fail to achieve remission.
Dominik Szawica +4 more
doaj +1 more source