Results 121 to 130 of about 23,526 (258)

Exercise‐induced effects on atherogenesis and tryptophan catabolism via the kynurenine pathway in an HIV‐associated atherosclerosis mouse model

Experimental Physiology, EarlyView.
Abstract A mouse model of HIV‐associated atherosclerosis (Tg26+/−ApoE−/−) exhibited increased plaque area compared with the ApoE−/− mouse, linked to elevated indoleamine 2,3‐dioxygenase (IDO) activity. IDO catalyses the conversion of tryptophan (TRP) into kynurenine (KYN), measured by the KYN‐to‐TRP ratio.
Marcus V. S. Rangel, Mohammad Afaque Alam, Mohammad Islamuddin, Zheng Chen, Xuebin Qin, Juliana P. Borges   +5 more
wiley   +1 more source

Does the kynurenine pathway play a pathogenic role in autism spectrum disorder?

Brain, Behavior, & Immunity - Health
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in communication, sociability, and repetitive/stereotyped behavior.
Danielle Santana-Coelho
doaj   +1 more source

The Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications [PDF]

, 2021
Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al‐Harrasi, Gökhan Zengin, Adrian Gheorghe Bumbu, Felicia Liana Andronie-Cioară, Aurelia Cristina Nechifor, Daniela Gîtea, Alexa Florina Bungău, Mirela Mărioara Toma, Simona Bungău   +13 more
openalex   +1 more source

Enviromimetics: From exercise mimetics to cognitomimetics in the quest for enhanced brain health and cognition

The Journal of Physiology, EarlyView.
Abstract figure legend A schematic diagram outlining the concept of enviromimetics, and the subclasses of exercise mimetics, epimimetics and cognitomimetics. The rationale is that environmental stimulation and lifestyle factors, including physical activity and cognitive stimulation, have shown beneficial effects across a range of human conditions ...
Anthony J. Hannan
wiley   +1 more source

Uncovering the Link Between Kynurenic Acid Pathway and Kidney Failure

Kidney International Reports
Introduction: Recent studies have focused on some uremic toxins, particularly those derived from tryptophan, as potential modifiable risk factors of chronic kidney disease (CKD) progression.
Carolla El Chamieh, Sophie Liabeuf, Islam Amine Larabi, Natalia Alencar De Pinho, Margaux Costes-Albrespic, Luc Frimat, Céline Lange, Yves-Édouard Herpe, Jean-Charles Martin, Pierre Letourneau, Benoit Bérengère, Christophe Soulage, Stéphane Burtey, Jean-Claude Alvarez, Laetitia Koppe, Ziad A. Massy, Prs T. Hannedouche, B. Moulin, Dr A. Klein, Pr C. Combe, Dr J.P. Bourdenx, Dr A. Keller, Dr C. Delclaux, Dr B. Vendrely, Dr B. Deroure, Dr A. Lacraz, Dr T. Lobbedez, Dr I. Landru, Pr Z. Massy, Pr P. Lang, Dr X. Belenfant, Pr E. Thervet, Dr P. Urena, Dr M. Delahousse, Dr C. Vela, Pr M. Essig, Dr D. Clément, Dr H. Sekhri, Dr M. Smati, Dr M. Jamali, Dr B. Hacq, Dr V. Panescu, Dr M. Bellou, Pr Luc Frimat, Pr N. Kamar, Prs C. Noël et F. Glowacki, Dr N. Maisonneuve, Dr R. Azar, Dr M. Hoffmann, Pr M. Hourmant, Dr A. Testa, Dr D. Besnier, Pr G. Choukroun, Dr G. Lambrey, Pr S. Burtey, Dr G. Lebrun, Dr E. Magnant, Pr M. Laville, Pr D. Fouque, L. Juillard, Dr C. Chazot, Pr P. Zaoui, Dr F. Kuentz   +62 more
doaj   +1 more source

The Crohn's Disease Exclusion Diet Across the Lifespan, Indications and the Globe: An Expert Review Towards Personalized Therapy in Crohn's Disease

JCC Plus, Volume 1, Issue 2, March 2026.
ABSTRACT Background and Aims The Crohn's disease (CD) exclusion diet (CDED) is an established treatment for active CD with a growing body of evidence supporting its use across diverse populations and disease phenotypes. Particularly effective in mild‐to‐moderate cases, CDED is recognized by clinical guidelines including ESPEN, AGA and ECCO nutritional ...
Rotem Sigall Boneh, Elena Banci, Luca Scarallo, Marta Herrador‐López, Emma P. Halmos, Dror S. Shouval, Nicolette Wierdsma, Chen Sarbagili‐Shabat, Víctor Manuel Navas‐López, Javier Martín‐de‐Carpi, Yulia Ron, Lindsey Albenberg, Henit Yanai, Franck Carbonnel, Johan Van Limbergen, Nitsan Maharshak, Paolo Lionetti, Eytan Wine   +17 more
wiley   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease [PDF]

, 2019
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins   +17 more
openalex   +1 more source

Functional Training Mitigates Reduced Circulating Indole‐3‐Lactate Levels in Persons With Relapsing–Remitting Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Indoles are tryptophan (Trp)‐derived metabolites that are produced by the gut microbiota and may influence the gut‐microbiota‐brain axis in multiple sclerosis (MS). Indole‐3‐lactate (ILA) is reduced in persons with MS and improves MS clinical scores in animal models via its anti‐inflammatory remyelinating properties.
Tiffany Wences Chirino, Frederike Adammek, Sergen Belen, Matteo Winker, Sebastian Proschinger, Annette Rademacher, Marit L. Schlagheck, Alexander Schenk, Marie Kupjetz, David Walzik, Clemens Warnke, Marcel Reuter, Friederike Rosenberger, Tim Meyer, Adrian McCann, Per Magne Ueland, Niklas Joisten, Philipp Zimmer   +17 more
wiley   +1 more source

Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia

Schizophrenia
Alterations in the kynurenine pathway of tryptophan metabolism have been implicated in the pathophysiology of schizophrenia. Here, we performed an in-depth analysis of all metabolites of the kynurenine pathway, i.e., tryptophan (TRY), kynurenic acid ...
Nico Antenucci, Giovanna D’Errico, Francesco Fazio, Ferdinando Nicoletti, Valeria Bruno, Giuseppe Battaglia   +5 more
doaj   +1 more source