Results 151 to 160 of about 34,492 (275)

Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT Chronic kidney disease (CKD) affects over 10% of the world's population and is associated with high morbidity and mortality rates. The management of CKD is complex; CKD alters drug pharmacokinetics and pharmacodynamics and further complicates therapeutic strategies regimens.
Sophie Liabeuf, Jessica Berdougo‐Tritz, Lucie Augey, Aïcha Mbarek, Michel Jadoul, Gilbert Deray, Ziad A. Massy   +6 more
wiley   +1 more source

Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk [PDF]

, 2013
Shu-Chun Chuang, Anouar Fanidi, Per Magne Ueland, Caroline L. Relton, Øivind Midttun, Dan J. Stein, Marc J. Gunter, Michael J. Seckl, Ruth C. Travis, Nicholas J. Wareham, Antonia Trichopoulou, Παγώνα Λάγιου, Dimitrios Trichopoulos, Petra H. Peeters, H. Bas Bueno‐de‐Mesquita, Heiner Boeing, Angelika Wientzek, Tilman Küehn, Rudolf Kaaks, ­Rosario ­Tumino, Claudia Agnoli, Domenico Palli, Alessio Naccarati, Eva Ardanáz, María‐José Sánchez, J. Ramón Quirós, María‐Dolores Chirlaque, Antonio Agudo, Mikael Johansson, Kjell Grankvist, Marie‐Christine Boutron‐Ruault, Françoise Clavel‐Chapelon, Guy Fagherazzi, Elisabete Weiderpass, Elio Ríboli, Paul Brennan, Paolo Vineis, Mattias Johansson   +37 more
openalex   +1 more source

Fighting obesity by targeting factors regulating beige adipocytes. [PDF]

, 2018
Purpose of reviewThe current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.Recent findingsWe outline recent studies ...
Koliwad, Suneil K, McQueen, Allison E, Wang, Jen-Chywan   +2 more
core   +1 more source

Antibiotic‐Induced Dysbiosis of the Gut Microbiota Shifts Host Tryptophan Metabolism and Increases the Susceptibility of Mice to Pulmonary Infection With Pseudomonas aeruginosa

Immunology, Volume 175, Issue 4, Page 453-466, August 2025.
Antibiotic‐induced dysbiosis of the gut microbiota shifts host tryptophan metabolism and impairs the innate immune response during Pseudomonas aeruginosa pulmonary infection. (A) Eubiosis: During eubiosis, the intestinal microbiota metabolises tryptophan into indole metabolites, which keeps tryptophan levels within normal serum concentrations. However,
Camila Bernardo de Brito, Raquel Duque do Nascimento Arifa, Rafael de Oliveira Bezerra, Carlos Eduardo Dias Igídio, Bárbara Maria de Amorim‐Santos, Anna Clara Paiva de Menezes Santos, Larissa Mendes Barbosa, João Paulo Pezzini Barbosa, Larissa Marcely Gomes Cassiano, Markus Kohlhoff, Micheli Fagundes, Rafaela Ribeiro Álvares Batista, Celso Martins Queiroz‐Junior, Alessandra M. Saliba, Juliana Divina Almeida Raposo, Fernão Castro Braga, Roney Santos Coimbra, Mauro Martins Teixeira, Caio Tavares Fagundes, Danielle G. Souza   +19 more
wiley   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, Volume 12, Issue 27, July 17, 2025.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

The Kynurenine Pathway of Tryptophan Catabolism, CD4+ T-Cell Recovery, and Mortality Among HIV-Infected Ugandans Initiating Antiretroviral Therapy [PDF]

, 2014
Helen Byakwaga, Yap Boum, Ying Huang, Conrad Muzoora, Annet Kembabazi, Sheri D. Weiser, John P. Bennett, H. Cao, Jessica E. Haberer, Steven G. Deeks, David R. Bangsberg, Joseph M. McCune, Jeffrey N. Martin, Peter W. Hunt   +13 more
openalex   +1 more source

Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION Elevated total homocysteine (tHcy) is a major predictor of brain atrophy, cognitive decline, and Alzheimer's disease (AD) progression. The VITACOG trial, a randomized, placebo‐controlled study in mild cognitive impairment (MCI), previously showed that B vitamin supplementation lowered tHcy, slowing brain atrophy and cognitive ...
Tereza Kacerova, Abi G. Yates, Jiayi Dai, Dawn Shepherd, Elisabete Pires, Sebastian de Jel, Qingxia Gong, Eric Schiffer, Fredrik Jernerén, Thomas Olsen, Celeste A. De Jager Loots, Helga Refsum, A. David Smith, James S. O. McCullagh, Daniel C. Anthony, Fay Probert   +15 more
wiley   +1 more source

Untargeted Metabolomic Analysis Using UPLC–MS/MS Reveals Metabolic Changes Associated With Lanmaoa asiatica Poisoning

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Lanmaoa asiatica possesses notable nutritional and pharmacological value, yet its potential to cause neuropsychiatric symptoms remains unclear. This study represents the first application of UPLC‐MS/MS non‐targeted metabolomics technology to systematically analyze the plasma metabolic profiles of patients with Lanmaoa asiatica poisoning, particularly ...
Ruanxian Dai, Zhantao Duan, Bin Han, Yating Peng, Lan Zhu, Yuan Shen, Qiang Meng   +6 more
wiley   +1 more source

Interferon gamma (IFN-γ)-mediated inflammation and the kynurenine pathway in relation to risk of hip fractures: the Hordaland Health Study [PDF]

, 2014
Ellen M. Apalset, Clara Gram Gjesdal, Per Magne Ueland, Jannike Øyen, Klaus Meyer, Øivind Midttun, Geir Egil Eide, Grethe S. Tell   +7 more
openalex   +1 more source

Nutrient‐Synbiotic Complex Ameliorates LPS‐Induced Depressive‐Like Behavior via Modulation of Gut Microbiota and Tryptophan Metabolism in Mice

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Complex interventions significantly prevent the depression‐like behaviors. Nutrient‐synbiotic complex presents the more beneficial effects. Nutrient‐synbiotic complex modifies the composition of gut microbial community. Nutrient‐synbiotic complex improves the tryptophan metabolic homeostasis.
Zhipeng Liu, Shengchao Shi, Xiaoyu Zhang, Chao Wu, Qin Yang, Simeng Ren, Yujuan Shan, Guanqiong Na   +7 more
wiley   +1 more source