Results 151 to 160 of about 23,526 (258)

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Xiu‐Fen Cheng, Belén Lucas, Philipp Lampe, Stefano Ugel, Suyuan Chen, Anke Unger, Matthias Bischoff, Soheila Rezaei Adariani, Kesava Reddy Naredla, Kamal Kumar, Annika Schmidt, Carsten Strohmann, Petra Janning, Raphael Gasper, María Lucas, Malte Gersch, Sonja Sievers, Vincenzo Bronte, Slava Ziegler, Herbert Waldmann   +19 more
wiley   +2 more sources

Supplementary Material for: The Kynurenine Pathway in Acute Kidney Injury and Chronic Kidney Disease

, 2021
Wee H.N., Jianjun Liu, J.Y.L. Ching, Kovalik J.-P., Lim C   +4 more
openalex   +1 more source

Review for "A single prenatal lipopolysaccharide injection has acute, but not long‐lasting, effects on cerebral kynurenine pathway metabolism in mice" [PDF]

, 2021
Danielle Coelho
openalex   +1 more source

Association Between Metabolic Syndrome, Obesity, and Cognitive Performances in Individuals With Bipolar Disorders: Cross‐Sectional and Longitudinal Analyses in the FACE‐BD Cohort

Acta Psychiatrica Scandinavica, Volume 153, Issue 2, Page 108-121, February 2026.
ABSTRACT Introduction Metabolic syndrome (MetS) has been suggested to be associated with cognitive impairments in bipolar disorder (BD); however, studies are limited by small sample sizes or cross‐sectional design. Our objective is to evaluate the cross‐sectional and longitudinal associations between MetS and cognitive performances in a large cohort of
I. Palimaru, B. Etain, M. Leboyer, Y. Dansou, P. Favre, S. Gard, V. Aubin, F. Bellivier, R. Belzeaux, P. Courtet, C. Dubertret, E. Haffen, A. Lefrere, P. M. Llorca, E. Olié, M. Polosan, L. Samalin, R. Schwan, the FondaMental Academic Centers of Expertise in Bipolar Disorders (FACE‐BD) Collaborators, B. Etain, E. Olié, M. Leboyer, E. Haffen, P. M. Llorca, V. Barteau, S. Bensalem, O. Godin, H. Laouamri, K. Souryis, S. Hotier, A. Pelletier, F. Hergeta, J. Petrucci, L. Willaume, F. Bellivier, B. Etain, V. Hennion, E. Marlinge, J. Meheust, A. Richard, M. Carminati, H. Francisque, S. Gard, K. M’Bailara, C. Elkael, F. Hoorelbeke, I. Minois, J. Sportich, N. Da Ros, C. Dubertret, N. Mazer, C. Portalier, C. Scognamiglio, A. Bing, P. Laurent, L. Boukhobza, P. Courtet, S. Denat, B. Deffinis, D. Ducasse, M. Gachet, A. Lengvenyté, F. Molière, L. Nass, E. Olié, G. Tarquini, A. Lefrere, E. Moreau, J. Pastol, F. Groppi, H. Polomeni, J. Bauberg, L. Lescalier, I. Muraccioli, A. Suray, R. Cohen, J. P. Kahn, M. Milazzo, O. Wajsbrot‐Elgrabli, T. Bougerol, A. Pouchon, A. Bertrand, B. Fredembach, A. Suisse, Q. Denoual, M. Polosan, A. M. Galliot, L. Brehon, G. Bonny, L. Durand, V. Feuga, N. Kayser, P. Roux, V. Aubin, I. Cussac, M. A. Dupont, J. Loftus, I. Medecin, C. Dubertret, N. Mazer, P. Laurent, L. Samalin, P. M. Llorca, M. Mennetrier, T. Bonnet, D. Lacelle, M. Vayssié, C. Beal, O. Blanc, P. Roux, O. Godin   +110 more
wiley   +1 more source

The Kynurenine Pathway: a Proposed Mechanism Linking Diabetes and Periodontal Disease in Diabetic Patients

Dental Hypotheses, 2011
Introduction: Diabetes mellitus is a metabolic disease characte-rized by dysregulation of carbohydrate, protein and lipid metabolism. Diabetes could result, in part, in activation of tryptophan metabolism.
Rishabh Kapila, KS Nagesh, Asha R. Iyengar, Subash BV. Adiga   +3 more
doaj  

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

Andrology, Volume 14, Issue 2, Page 496-515, February 2026.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma   +8 more
wiley   +1 more source

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer [PDF]

, 2019
Niranjan Venkateswaran, M. Carmen Lafita‐Navarro, Yi-Heng Hao, Jessica A. Kilgore, Lizbeth Perez‐Castro, Jonathan Braverman, Nofit Borenstein‐Auerbach, Min Kim, Nicholas P. Lesner, Prashant Mishra, Thomas Brabletz, Jerry W. Shay, Ralph J. DeBerardinis, Noelle S. Williams, Ömer Yılmaz, Maralice Conacci‐Sorrell   +15 more
openalex   +1 more source

Tryptophan and Kynurenine Pathway Metabolites and Psychoneurological Symptoms Among Breast Cancer Survivors

, 2022
Hongjin Li, Mark B. Lockwood, Judith M. Schlaeger, Tingting Liu, Oana C. Danciu, Ardith Z. Doorenbos   +5 more
openalex   +2 more sources

Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives [PDF]

, 2021
Ilona Sadok, Magdalena Staniszewska
openalex   +1 more source

Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma

Cancer Science, Volume 117, Issue 2, Page 325-334, February 2026.
IDO expression in stromal cells was upregulated by MM cells via the JAK–STAT1–NF‐κB–IRF1 signaling pathway. JAK inhibitor abolished IDO and IRF1 upregulation. ABSTRACT Stromal cells are an essential component of the tumor microenvironment (TME) in multiple myeloma (MM). Indoleamine 2,3‐dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to
Toru Ebina, Masaki Ri, Yoshiaki Marumo, Tomoyuki Nakamura, Hirokazu Sasaki, Yoshiko Oshima, Takahiro Nakashima, Shinya Hagiwara, Arisa Asano, Shiori Kinoshita, Tomotaka Suzuki, Tomoko Narita, Ayako Masaki, Takaomi Sanda, Kazufumi Yamagata, Kohmei Kubo, Hirokazu Komatsu, Hirotake Sakuraba, Shinsuke Iida   +18 more
wiley   +1 more source