Results 161 to 170 of about 34,492 (275)

Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia

Schizophrenia
Alterations in the kynurenine pathway of tryptophan metabolism have been implicated in the pathophysiology of schizophrenia. Here, we performed an in-depth analysis of all metabolites of the kynurenine pathway, i.e., tryptophan (TRY), kynurenic acid ...
Nico Antenucci, Giovanna D’Errico, Francesco Fazio, Ferdinando Nicoletti, Valeria Bruno, Giuseppe Battaglia   +5 more
doaj   +1 more source

l-Tryptophan-l-Kynurenine Pathway Metabolism Accelerated byToxoplasmagondiiInfection Is Abolished in Gamma Interferon-Gene-Deficient Mice: Cross-Regulation between Inducible Nitric Oxide Synthase and Indoleamine-2,3-Dioxygenase

, 2002
Suwako Fujigaki, Kuniaki Saito, Masao Takemura, Naoya Maekawa, Yasuhiro Yamada, Hisayasu Wada, Mitsuru Seishima   +6 more
openalex   +1 more source

The Kynurenine Pathway of Tryptophan Degradation is Activated During Osteoblastogenesis [PDF]

, 2014
Christopher Vidal, Wei Li, Brigitte Santner‐Nanan, Chai K. Lim, Gilles J. Guillemin, Helen J. Ball, Nicholas H. Hunt, Ralph Nanan, Gustavo Duque   +8 more
openalex   +1 more source

Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease

MedComm, Volume 6, Issue 7, July 2025.
Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song, Bin Liu, Haiou Wang, Wei Sun   +3 more
wiley   +1 more source

Metabolites of the Kynurenine Pathway of Tryptophan Metabolism in the Cerebrospinal Fluid of Malawian Children with Malaria

, 2003
Isabelle M. Medana, Nicholas P. J. Day, Houta Salahifar‐Sabet, Roland Stocker, George A. Smythe, Lloyd Bwanaisa, Alfred Njobvu, K Kayira, Gareth D. H. Turner, Terrie E. Taylor, Nicholas H. Hunt   +10 more
openalex   +1 more source

The Role of Inflammation in Migraine Headaches: A Review

FASEB BioAdvances, Volume 7, Issue 7, July 2025.
Inflammation plays a crucial role in the onset and intensity of both migraine headache symptoms and attacks. Pro‐inflammatory neurotransmitters and mediators released from neural cells and tissues that contributes to increase in nitric oxide, increase in glutamate, alterations in serotonin and dopamine levels and pain perception are involved in ...
Caryn T. Morgan, Sanah M. Nkadimeng
wiley   +1 more source

Exploring Early Childhood Development Interventions for Building Human Capital in Sub‐Saharan Africa: A Scoping Review

Child: Care, Health and Development, Volume 51, Issue 4, July 2025.
ABSTRACT Background Inequalities in the provision and implementation of early childhood development (ECD) interventions in Sub‐Saharan Africa remain a challenge. This scoping review aimed to investigate the types and extent of ECD interventions in this region, using the Nurturing Care framework (NCF).
Johanna Beukes, Stephanie Alcock, Michelle Leal, Urlridge Thompson, Catherine E. Draper, Shane A. Norris   +5 more
wiley   +1 more source

13C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder [PDF]

, 2015
Toshiya Teraishi, Hiroaki Hori, Daimei Sasayama, Junko Matsuo, Shintaro Ogawa, Miho Ota, Kotaro Hattori, Masahiro Kajiwara, Teruhiko Higuchi, Hiroshi Kunugi   +9 more
openalex   +1 more source

Functional Impairments in Learning and Signal Propagation Following Prenatal Kynurenine Treatment in Mice

European Journal of Neuroscience, Volume 62, Issue 1, July 2025.
ABSTRACT The levels of kynurenic acid (KYNA), a metabolite of the kynurenine pathway (KP) of tryptophan degradation, are elevated in the brain of persons with schizophrenia (SZ) and may be linked to cognitive dysfunctions in the disease. Studies in rats indicate that abnormally high fetal brain KYNA may play a pathophysiologically significant role in ...
Sarah Beggiato, P. Leon Brown, Snezana Milosavljevic, Marian A. R. Thomas, Maria V. Piroli, Korrapati V. Sathyasaikumar, Francesca M. Notarangelo, Robert Schwarcz, Ana Pocivavsek   +8 more
wiley   +1 more source

Anti-infectious Activity of Tryptophan Metabolites in the L-Tryptophan-L-Kynurenine Pathway

, 2009
Koji Narui, Norihisa Noguchi, Aya Saito, Kazuhiro Kakimi, Noboru Motomura, Kin‐ya Kubo, Shinichi Takamoto, Masanori Sasatsu   +7 more
openalex   +2 more sources