Results 11 to 20 of about 23,526 (258)
The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors [PDF]
Molecules, 2022 Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan.
Tamera D. Hughes +4 more
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Kynurenine acid - metabolism and regulation of kynurenine pathway
Journal of Education, Health and Sport, 2017 Kynurenic acid (KYNA) was first isolated from the dog's urine in 1853 by german chemist Justus von Liebig. KYNA probably plays an important role in the pathogenesis of many neurodegenerative and psychiatric diseases. Its elevated concentration were found
Piotr Kozłowski, Magdalena Kozlowska
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Kynurenine Pathway in Psoriasis—a Promising Link?
Dermatology and Therapy, 2023 Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome.
A. Stepaniuk, A. Baran, I. Flisiak
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Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition [PDF]
Frontiers in Molecular Biosciences, 2019 The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips +4 more
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Kynurenine pathway in kidney diseases [PDF]
Pharmacological Reports, 2021 AbstractKidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders the prevalence of these diseases will increase over the coming decades. Despite available laboratory tests, accurate and rapid diagnosis of renal dysfunction has yet to be realized, and prognosis ...
Izabela Zakrocka, Wojciech Załuska
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Critical Care Medicine, 2012 The kynurenine pathway represents a major route for the catabolism of tryptophan (TRP). In the body, TRP is transported around the periphery either bound to albumin (90%) or in free form (10%), the two states existing in equilibrium (McMenamy 1965). However, only free form TRP can be transported across the blood-brain barrier (BBB) by the competitive ...
Yiquan Chen, Gilles Guillemi
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The tryptophan–kynurenine pathway in immunomodulation and cancer metastasis
Cancer Medicine, 2023 Introduction The activation of the kynurenine pathway in cancer progression and metastasis through immunomodulatory pathways has drawn attention to the potential for kynurenine pathway inhibition.
Charlise Basson +3 more
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Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease
Frontiers in Immunology, 2022 Coronary artery disease (CAD) is one of the leading cause of mortality worldwide. Several risk factors including unhealthy lifestyle, genetic background, obesity, diabetes, hypercholesterolemia, hypertension, smoking, age, etc.
Renáta Gáspár +10 more
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Promising Gastric Cancer Biomarkers-Focus on Tryptophan Metabolism via the Kynurenine Pathway. [PDF]
Int J Mol SciOżga K +3 more
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Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. [PDF]
PLoS ONE, 2015 The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders ...
Simon P Jones +8 more
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