Results 21 to 30 of about 20,721 (222)

Imbalanced Kynurenine Pathway in Schizophrenia [PDF]

International Journal of Tryptophan Research, 2014
Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia. It has been proposed that increased brain KYNA levels in schizophrenia result from a pathological shift in the kynurenine pathway toward enhanced KYNA formation, away from the other branch of the pathway leading to quinolinic acid (QUIN).
Kegel, Magdalena E., Bhat, Maria, Skogh, Elisabeth, Samuelsson, Martin, Lundberg, Kristina, Dahl, Marja-Liisa, Sellgren, Carl, Schwieler, Lilly, Engberg, Göran, Schuppe-Koistinen, Ina, Erhardt, Sophie   +10 more
openaire   +4 more sources

Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

Mediators of Inflammation, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs.
Sagar Vyavahare, Sandeep Kumar, Nicholas Cantu, Ravindra Kolhe, Wendy B. Bollag, Meghan E. McGee-Lawrence, William D. Hill, Mark W. Hamrick, Carlos M. Isales, Sadanand Fulzele   +9 more
doaj   +1 more source

Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review

Journal of Neuroinflammation, 2020
Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel, Christoph Mulert   +3 more
doaj   +1 more source

Kynurenine Pathway in Respiratory Diseases. [PDF]

Int J Tryptophan Res
The kynurenine pathway is the primary route for tryptophan catabolism and has received increasing attention as its association with inflammation and the immune system has become more apparent. This review provides a broad overview of the kynurenine pathway in respiratory diseases, from the initial observations to the characterization of the different ...
Pamart G, Gosset P, Le Rouzic O, Pichavant M, Poulain-Godefroy O.   +4 more
europepmc   +3 more sources

The kynurenine pathway and neurodegenerative disease [PDF]

Seminars in Cell & Developmental Biology, 2015
Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan is an essential amino acid required for protein synthesis, and in higher eukaryotes is also converted into the key neurotransmitters serotonin and tryptamine. However, in mammals
Maddison, Daniel C., Giorgini, Flaviano
openaire   +4 more sources

Kynurenine Pathway of Tryptophan Metabolism Is Associated with Hospital Mortality in Patients with Acute Respiratory Distress Syndrome: A Prospective Cohort Study

Antioxidants, 2022
Acute respiratory distress syndrome (ARDS) involves dysregulated immune-inflammatory responses, characterized by severe oxidative stress and high mortality.
Li-Chung Chiu, Hsiang-Yu Tang, Chun-Ming Fan, Chi-Jen Lo, Han-Chung Hu, Kuo-Chin Kao, Mei-Ling Cheng   +6 more
doaj   +1 more source

Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial

Journal of Neuroinflammation, 2021
Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer, Matthias Heinzl, Anthi Faka, Michael Resl, Ada Trepci, Carmen Klammer, Margot Egger, Benjamin Dieplinger, Martin Clodi, Lilly Schwieler   +9 more
doaj   +1 more source

Kynurenine pathway in bipolar disorder [PDF]

Psychiatriki, 2019
Bipolar disorder (BD) is a chronic psychiatric illness which, among other things, is characterized by cerebral dysfunctions, cognitive disorders and sleep disturbances. The neurobiological basis of these processes remains unclear. In recent years, studies have focused on the role of immune-inflammatory mechanisms induced by the tryptophan metabolism ...
Ger Konstantinou, E Angelopoulos, C C Papageorgiou   +2 more
openaire   +3 more sources

Kynurenines in CNS disease: regulation by inflammatory cytokines

Frontiers in Neuroscience, 2014
The kynurenine pathway metabolizes the essential amino acid tryptophan and generates a number of neuroactive metabolites collectively called the kynurenines.
Brian M Campbell, Erik eCharych, Anna W Lee, Thomas eMöller   +3 more
doaj   +1 more source

The kynurenine pathway is involved in bacterial meningitis [PDF]

Journal of Neuroinflammation, 2014
Bacterial meningitis (BM) is characterized by an intense host inflammatory reaction, which contributes to the development of brain damage and neuronal sequelae. Activation of the kynurenine (KYN) pathway (KP) has been reported in various neurological diseases as a consequence of inflammation.
Coutinho Leonam G., Christen Stephan, Bellac Caroline L., Fontes Fabrcia Lima, Soares de Souza Fladjule Rejane, Grandgirard Denis, Leib Stephen L., Agnez-Lima Lucymara F.   +7 more
openaire   +6 more sources