Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]
, 2015 Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA +4 more
core +1 more source
Antioxidants, 2022 Acute respiratory distress syndrome (ARDS) involves dysregulated immune-inflammatory responses, characterized by severe oxidative stress and high mortality.
Li-Chung Chiu +6 more
doaj +1 more source
Obesity and cancer: existing and new hypotheses for a causal connection [PDF]
, 2018 Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly, but recent evidence suggests a major role for chronic inflammation in cancer
Darlington, L. Gail +2 more
core +2 more sources
Kynurenines in CNS disease: regulation by inflammatory cytokines
Frontiers in Neuroscience, 2014 The kynurenine pathway metabolizes the essential amino acid tryptophan and generates a number of neuroactive metabolites collectively called the kynurenines.
Brian M Campbell +3 more
doaj +1 more source
Kynurenine Pathway in Psoriasis—a Promising Link?
Dermatology and Therapy, 2023 Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome.
A. Stepaniuk, A. Baran, I. Flisiak
doaj +1 more source
Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. [PDF]
, 2016 Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing.
Abu Aboud, Omran +13 more
core +2 more sources
Epigenetic programming of obesity in early life through modulation of the kynurenine pathway. [PDF]
Int J Obes (Lond)Gharipour M, Craig JM, Stephenson G.
europepmc +2 more sources
Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]
, 2010 Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
Berfelo, M. W. +6 more
core +2 more sources
PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]
, 2019 Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G +10 more
core +2 more sources
Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain
Pharmaceuticals, 2023 Chronic pain is a pressing medical and socioeconomic issue worldwide. It is debilitating for individual patients and places a major burden on society in the forms of direct medical costs and lost work productivity.
Andrew Auyeung +3 more
doaj +1 more source