Results 31 to 40 of about 23,526 (258)

Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer. [PDF]

Nat Commun
Liu Y, Liu Z, Hu Y, Ling Y, Qing S, Liu Y, Zhan Y, Shen Z, Fang Y, Deng H.   +9 more
europepmc   +3 more sources

The kynurenine pathway and neurodegenerative disease [PDF]

Seminars in Cell & Developmental Biology, 2015
Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan is an essential amino acid required for protein synthesis, and in higher eukaryotes is also converted into the key neurotransmitters serotonin and tryptamine. However, in mammals
Maddison, Daniel C., Giorgini, Flaviano
openaire   +3 more sources

Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain

Pharmaceuticals, 2023
Chronic pain is a pressing medical and socioeconomic issue worldwide. It is debilitating for individual patients and places a major burden on society in the forms of direct medical costs and lost work productivity.
Andrew Auyeung, Hank C. Wang, Kannan Aravagiri, Nebojsa Nick Knezevic   +3 more
doaj   +1 more source

The effect of electroconvulsive therapy (ECT) on serum kynurenine pathway metabolites in late-life depression

Journal of Affective Disorders Reports, 2023
Background: Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while others are considered ...
Tore Ivar Malmei Aarsland, Jan Haavik, Arve Ulvik, Per Magne Ueland, Annemiek Dols, Ute Kessler   +5 more
doaj   +1 more source

The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Introduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili, Alina Seryogina, Mira Beisembayeva, Shynar Muratbekova, Ivan Turkevich, Yelena Shayakhmetova   +5 more
doaj   +1 more source

The kynurenine pathway: Towards metabolic equilibrium [PDF]

Neuropharmacology, 2017
No abstract available.
Clarke, Gerard, Stone, Trevor W., Schwarcz, Robert   +2 more
openaire   +2 more sources

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma

Frontiers in Oncology, 2020
Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites
Soudabeh Rad Pour, Hiromasa Morikawa, Narsis A. Kiani, Narsis A. Kiani, David Gomez-Cabrero, David Gomez-Cabrero, Alistair Hayes, Xiaozhong Zheng, Maria Pernemalm, Janne Lehtiö, Damian J. Mole, Johan Hansson, Johan Hansson, Hanna Eriksson, Hanna Eriksson, Jesper Tegnér, Jesper Tegnér, Jesper Tegnér   +17 more
doaj   +1 more source

Peripheral tryptophan and serotonin and kynurenine pathways in major depression: A case-control study

European Psychiatry, 2021
Introduction The tryptophan pathway along with its two branches of metabolism to serotonin and kynurenine seems to be affected in major depression.
R. Colle, C. Verstuyft, D. David, P. Chanson, E. Corruble   +4 more
doaj   +1 more source

Kynurenine pathway and human systems

Experimental Gerontology, 2020
The essential amino acid L-tryptophan (Trp) appears to play an important role in aging by acting as a general regulator of protein homeostasis. The major route of Trp degradation, the kynurenine pathway (KP), produces a range of biologically active metabolites that can impact or be impacted by a variety of body systems, including the endocrine ...
openaire   +2 more sources

Kynurenine pathway metabolites in migraine [PDF]

The Journal of Headache and Pain, 2015
Kynurenine pathway (KP), the quantitatively main branch of tryptophan metabolism, has long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to activate glutamate receptors, thus potentially influencing a large group of functions in the central ...
openaire   +2 more sources