Results 31 to 40 of about 2,406 (97)

Alterations in the Blood Kynurenine Pathway Following Long-Term PM2.5 and PM10 Exposure: A Cross-Sectional Study

Biomedicines
Human exposure to PM2.5 and PM10 has been linked to respiratory and cardiovascular diseases through inflammation activation. The kynurenine pathway is associated with inflammation, and it is necessary to investigate the effects of long-term PM2.5 and ...
Churdsak Jaikang, Giatgong Konguthaithip, Yutti Amornlertwatana, Narongchai Autsavapromporn, Sirichet Rattanachitthawat, Tawachai Monum   +5 more
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Decreased Plasma Levels of Kynurenine and Kynurenic Acid in Previously Treated and First-Episode Antipsychotic-Naive Schizophrenia Patients

Cells, 2023
Tryptophan (TRP) catabolites exert neuroactive effects, with the plethora of evidence suggesting that kynurenic acid (KYNA), a catabolite of the kynurenine pathway (KP), acts as the regulator of glutamate and acetylcholine in the brain, contributing to ...
Miloš Marković, Nataša Petronijević, Milena Stašević, Ivana Stašević Karličić, Milica Velimirović, Tihomir Stojković, Slavica Ristić, Mina Stojković, Nataša Milić, Tatjana Nikolić   +9 more
doaj   +1 more source

Dissecting the enigma of scleroderma: possible involvement of the kynurenine pathway

Pteridines, 2017
The kynurenine pathway (KP) is the metabolic pathway via which L-tryptophan is converted to nicotinamide. It serves important immune-regulatory roles. This article will review the evidence for involvement of the KP in scleroderma and present a possible ...
Noakes Rowland
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The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis

Microorganisms, 2021
In children, tick-borne encephalitis and neuroborreliosis are common infections affecting the central nervous system. As inflammatory pathways including cytokine expression are activated in these children and appear to be of importance for outcome, we ...
Ronny Wickström, Åsa Fowler, Michel Goiny, Vincent Millischer, Sofia Ygberg, Lilly Schwieler   +5 more
doaj   +1 more source

Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio

Lipids in Health and Disease, 2020
Background Non-alcoholic fatty liver disease is often associated with obesity, insulin resistance, dyslipidemia, and the metabolic syndrome in addition to mitochondrial dysfunction and nicotinamide adenine dinucleotide (NAD+) deficiency.
Rolf K. Berge, Daniel Cacabelos, Rosa Señarís, Jan Erik Nordrehaug, Ottar Nygård, Jon Skorve, Bodil Bjørndal   +6 more
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Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia–Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis

Advanced Science, 2022
Hepatic ischemia–reperfusion (IR) injury remains a common issue lacking effective strategy and validated pharmacological targets. Here, using an unbiased metabolomics screen, this study finds that following murine hepatic IR, liver 3‐hydroxyanthranilic ...
Bowen Xu, Peng Zhang, Xiaolong Tang, Shiguan Wang, Jing Shen, Yuanwen Zheng, Chao Gao, Ping Mi, Cuijuan Zhang, Hui Qu, Shiyang Li, Detian Yuan   +11 more
doaj   +1 more source

The effect of electroconvulsive therapy (ECT) on serum kynurenine pathway metabolites in late-life depression

Journal of Affective Disorders Reports, 2023
Background: Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while others are considered ...
Tore Ivar Malmei Aarsland, Jan Haavik, Arve Ulvik, Per Magne Ueland, Annemiek Dols, Ute Kessler   +5 more
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Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Malaria Journal, 2017
Background One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g.
Dag Holmberg, Elisabeth Franzén-Röhl, Richard Idro, Robert O. Opoka, Paul Bangirana, Carl M. Sellgren, Ronny Wickström, Anna Färnert, Lilly Schwieler, Göran Engberg, Chandy C. John   +10 more
doaj   +1 more source

Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Background: Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy with a poor prognosis. Although studies have shown metabolic reprogramming to be linked to ESCC development, no prognostic metabolic biomarkers or potential ...
Zhongjian Chen, Zhongjian Chen, Zhongjian Chen, Zhongjian Chen, Yalan Dai, Yalan Dai, Yalan Dai, Xiancong Huang, Xiancong Huang, Xiancong Huang, Keke Chen, Keke Chen, Keke Chen, Keke Chen, Yun Gao, Yun Gao, Yun Gao, Na Li, Na Li, Na Li, Ding Wang, Ding Wang, Ding Wang, Aiping Chen, Aiping Chen, Aiping Chen, Qingxia Yang, Yanjun Hong, Su Zeng, Weimin Mao, Weimin Mao, Weimin Mao   +31 more
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A distinct profile of tryptophan metabolism along the kynurenine pathway downstream of Toll-like receptor activation in irritable bowel syndrome

Frontiers in Pharmacology, 2012
Irritable bowel syndrome (IBS), a disorder of the brain-gut axis, is characterised by the absence of reliable biological markers. Tryptophan is an essential amino acid that serves as a precursor to serotonin but which can alternatively be metabolised ...
Gerard eClarke, Gerard eClarke, Gerard eClarke, Declan P McKernan, Gabor eGaszner, Eamonn M Quigley, Eamonn M Quigley, John F Cryan, John F Cryan, Timothy G Dinan, Timothy G Dinan   +10 more
doaj   +1 more source