Results 41 to 50 of about 20,721 (222)

Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway

Cell Communication and Signaling, 2023
Background Metabolic reprogramming is a critical event for cell fate and function, making it an attractive target for clinical therapy. The function of metabolic reprogramming in Helicobacter pylori (H.
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu   +10 more
doaj   +1 more source

Kynurenine pathway in Parkinson's disease—An update

eNeurologicalSci, 2020
Parkinson's disease (PD) is a complex multi-factorial neurodegenerative disorder where various altered metabolic pathways contribute to the progression of the disease. Tryptophan (TRP) is a major precursor in kynurenine pathway (KP) and it has been discussed in various in vitro studies that the metabolites quinolinic acid (QUIN) causes neurotoxicity ...
Dhivya Venkatesan, Arul Narayanasamy, Balachandar Vellingiri, Mahalaxmi Iyer, Kamalakannan Siva   +4 more
openaire   +3 more sources

Kynurenine pathway and human systems

Experimental Gerontology, 2020
The essential amino acid L-tryptophan (Trp) appears to play an important role in aging by acting as a general regulator of protein homeostasis. The major route of Trp degradation, the kynurenine pathway (KP), produces a range of biologically active metabolites that can impact or be impacted by a variety of body systems, including the endocrine ...
openaire   +3 more sources

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders

Frontiers in Immunology, 2021
ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov, Katrien Skorobogatov, Livia De Picker, Livia De Picker, Robert Verkerk, Violette Coppens, Violette Coppens, Marion Leboyer, Marion Leboyer, Marion Leboyer, Marion Leboyer, Norbert Müller, Manuel Morrens, Manuel Morrens   +13 more
doaj   +1 more source

The Kynurenine Pathway

, 2012
The kynurenine pathway represents a major route for the catabolism of tryptophan (TRP). In the body, TRP is transported around the periphery either bound to albumin (90%) or in free form (10%), the two states existing in equilibrium (McMenamy 1965). However, only free form TRP can be transported across the blood-brain barrier (BBB) by the competitive ...
Gilles J. Guillemin, Yiquan Chen
openaire   +3 more sources

Inhibitors of the Kynurenine Pathway [PDF]

, 2017
A central role in the immune escape of tumors has been attributed to the kynurenine pathway of tryptophan metabolism, leading to the depletion of tryptophan and the production of different bioactive metabolites. The first and rate-limiting step in this pathway is catalyzed by the phylogenetically unrelated enzymes indoleamine 2,3-dioxygenase 1 (IDO1 ...
Ute F. Röhrig, Olivier Michielin, Olivier Michielin, Vincent Zoete   +3 more
openaire   +2 more sources

Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity

European Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Slovák L., Poništ S., Kuncírová V., Mihalová D., Fedorova T., Bauerová K.   +5 more
doaj   +1 more source

The kynurenine pathway: Towards metabolic equilibrium [PDF]

Neuropharmacology, 2017
No abstract available.
Clarke, Gerard, Stone, Trevor W., Schwarcz, Robert   +2 more
openaire   +3 more sources

Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

European Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Csanova A., Jezova D.
doaj   +1 more source

Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD

Pharmaceuticals, 2023
Objectives: Despite distinct clinical profiles, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients share a remarkable portion of pathological features, with a substantial percentage of patients displaying a mixed disease ...
Annelies Heylen, Yannick Vermeiren, Ido P. Kema, Martijn van Faassen, Claude van der Ley, Debby Van Dam, Peter P. De Deyn   +6 more
doaj   +1 more source