Results 1 to 10 of about 13,274 (135)

L‒asparaginase activity in some endophytic fungi: Glutaminase‒free and low urease co‒activities. [PDF]

PLoS ONE
In this study, L‒asparaginase production in several endophytic fungi was evaluated along with their L‒glutaminase and urease co-activities. The effect of L‒asparagine and different culture media on L-asparaginase production were also evaluated. Among the
Zahra Zaeimian, Khalil-Berdi Fotouhifar, Mohsen Farzaneh   +2 more
doaj   +2 more sources

Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics [PDF]

Frontiers in Immunology
L-asparaginase, a critical enzyme for cancer therapy, has been primarily produced by microbes. Researches are being conducted to identify better stabilizing, low immunogenicity and highly active alternative sources has focused on marine microorganisms ...
Ritika Gopalakrishnan, Kamala Kannan, Ragul Gunasekaran, Priya Ramachandran, Dhanraj Ganapathy, Pitchiah Sivaperumal   +5 more
doaj   +2 more sources

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand [PDF]

Cell Death Discovery
L-asparaginase is an indispensable chemotherapeutic drug for patients with acute lymphoblastic leukemia (aLL), a life-threatening lymphoid neoplasm and the prime cause of cancer death among children.
Jung Kwon Lee, Karl Riabowol, Xidi Wang, Ki-Young Lee   +3 more
doaj   +2 more sources

Recombinant L-asparaginase from Stenotrophomonas maltophilia: a promising low-immunogenic anticancer agent [PDF]

Microbial Cell Factories
L-asparaginase is a crucial enzyme used in chemotherapy regimens for the treatment of acute lymphoblastic leukemia (ALL), its incorporation in the pediatric treatment protocols helped in achieving a high cure rate.
Nada A. Abdelrazek, Sarra E. Saleh, Amal E. Ali, Mohammad M. Aboulwafa, Marwa M. Raafat   +4 more
doaj   +2 more sources

PKA inhibition kills l-asparaginase-resistant leukemic cells from relapsed acute lymphoblastic leukemia patients [PDF]

Cell Death Discovery
Despite the success in treating newly diagnosed pediatric acute lymphoblastic leukemia (aLL), the long-term cure rate for the 20% of children who relapse is poor, making relapsed aLL the primary cause of cancer death in children.
Jung Kwon Lee, Xidi Wang, Jinghua Wang, Jesusa L. Rosales, Ki-Young Lee   +4 more
doaj   +2 more sources

Recent advances in L-Asparaginase enzyme production and formulation development for acrylamide reduction during food processing [PDF]

Food Chemistry: X
L-asparagine is an essential amino acid for cell growth and common constituent of all the proteins. During high temperature food processing it reacts with reducing sugars and leads to acrylamide production through a complex process known as Maillard ...
Arindam Jana, Soumyajit Biswas, Ritu Ghosh, Rahul Modak   +3 more
doaj   +2 more sources

Microbial L-asparaginase for Application in Acrylamide Mitigation from Food: Current Research Status and Future Perspectives

Microorganisms, 2021
L-asparaginase (E.C.3.5.1.1) hydrolyzes L-asparagine to L-aspartic acid and ammonia, which has been widely applied in the pharmaceutical and food industries.
Ruiying Jia, Xiao Wan, Xu Geng, Deming Xue, Zhenxing Xie, Chaoran Chen   +5 more
doaj   +1 more source

L-Asparaginase-Based Biosensors [PDF]

Encyclopedia, 2021
L-asparaginase (ASNase) is an aminohydrolase enzyme widely used in the pharmaceutical and food industries. Although currently its main applications are focused on the treatment of lymphoproliferative disorders such as acute lymphoblastic leukemia (ALL) and acrylamide reduction in starch-rich foods cooked at temperatures above 100 °C, its use as a ...
João C. F. Nunes, Raquel O. Cristóvão, Valéria C. Santos-Ebinuma, Joaquim L. Faria, Cláudia G. Silva, Márcia C. Neves, Mara G. Freire, Ana P. M. Tavares   +7 more
openaire   +3 more sources

Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia. [PDF]

PLoS ONE, 2015
Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration.
Hideki Yoshida, Toshihiko Imamura, Akiko M Saito, Yoshihiro Takahashi, So-ichi Suenobu, Daiichiro Hasegawa, Takao Deguchi, Yoshiko Hashii, Hirohide Kawasaki, Mikiya Endo, Hiroki Hori, Nobuhiro Suzuki, Yoshiyuki Kosaka, Koji Kato, Keiko Yumura-Yagi, Junichi Hara, Megumi Oda, Atsushi Sato, Keizo Horibe, Japan Association of Childhood Leukemia Study   +19 more
doaj   +1 more source

The nutritional and cultural conditions in shake flask culture for improved production of L-Asparaginase from endophytic fungus Fusarium sp. LCJ324: A sequential statistical method

Italian Journal of Mycology, 2023
L-Asparaginase has a greater demand due to its potential application in the food industry as well as in the pharmaceutical industry. To meet this demand, optimization of nutritional as well as physical conditions is critical for scaling up the production
Elangovan Udayan, Anbarasu Kathiravan, John Joel Gnanadoss   +2 more
doaj   +1 more source