Pharmaceutics, 2021 l-asparaginase is an enzyme used as treatment for acute lymphoblastic leukemia (ALL) due to its ability to hydrolyze l-asparagine, an essential amino acid synthesized by normal cells unlike neoplastic cells.
Marcela Freitas +9 more
doaj +1 more source
Investigating the L-asparaginase Production in the Yeast Yarrowia Lipolytica [PDF]
Biological Journal of Microorganism, 2018 Introduction: L-Asparaginase catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia. This enzyme is used for the treatment of patients with acute lymphoblastic leukemia, melanosarcoma and lymphosarcoma.
Farshad Darvishi, Fereshteh Shamsi
doaj +1 more source
Isolation and screening of l-asparaginase free of glutaminase and urease from fungal sp. [PDF]
, 2016 l-Asparaginase is a chemotherapeutic drug used in the treatment of acute lymphoblastic leukaemia (ALL), a malignant disorder in children. l-Asparaginase helps in removing acrylamide found in fried and baked foods that is carcinogenic in nature.
Devarai, Santhosh Kumar, Doriya, K
core +1 more source
Jurnal Kimia Sains dan Aplikasi, 2010 Enzim L-Asparaginase merupakan enzim yang menghidrolisis L-asparagin menjadi asam L-aspartat dan amonia. L-Asparaginase dapat digunakan untuk mengobati penyakit kanker, yang bekerja dengan cara menghambat sintesis protein sel kanker tanpa merusak sel ...
Oktarina Puspitasari, Wuryanti Wuryanti
doaj +1 more source
Solid state fermentation: An effective fermentation strategy for the production of L-asparaginase by Fusarium culmorum (ASP-87) [PDF]
, 2017 Production of L-asparaginase by Fusarium culmorum (ASP-87) isolated from tropical soil was investigated under solid state fermentation on a laboratory scale using sixty five (65) agro based materials.
Janakiraman, S., Meghavarnam, A.K.
core +1 more source
Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]
, 2020 Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core +1 more source
A simple and efficient dye-based technique for rapid screening of fungi for L-asparaginase production [PDF]
, 2015 Three hundred and sixty four (364) isolates of tropical soil fungi were screened for L-asparaginase production by rapid plate method using modified Czapek-Dox agar containing L-asparagine, and either bromo cresol purple or phenol red dye as an indicator.
Savitha Janakiraman, .
core +1 more source
L-Asparaginase from Penicillium sizovae Produced by a Recombinant Komagataella phaffii Strain
Pharmaceuticals, 2022 L-asparaginase is an important enzyme in the pharmaceutical field used as treatment for acute lymphoblastic leukemia due to its ability to hydrolyze L-asparagine, an essential amino acid synthesized by normal cells, but not by neoplastic cells.
Marcela Freitas +10 more
doaj +1 more source
Cloning and Gene Expression of AnsZ Encoding L-Asparaginase Enzyme from Local Bacillus sp.
Microbiology Indonesia, 2014 L-asparaginase is an enzyme that catalyzes the hydrolysis of L-asparagine into L-aspartic acid and ammonia. In medical aspect, L-asparaginase especially those came from E.
RIMA AZARA +3 more
doaj +1 more source
Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine [PDF]
, 2020 The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites.
Amoozegar, Mohammad Ali +2 more
core +1 more source