Results 31 to 40 of about 22,679 (205)

Molecular docking analysis of H1 and H2 antihistamines groups with l-asparaginase II for reducing allergenicity; an in silico approach

Informatics in Medicine Unlocked, 2022
Introduction: Cancer is a pervasive disease with different types spreading widely worldwide. Acute lymphoblastic leukemia (ALL) is the bone marrow lymphocyte cancer related to the malignancy of B or T lymphoblast white blood cells.
Masoumeh Massah, Negar Balmeh, Kiomars Goodarzi, Najaf Allahyari Fard   +3 more
doaj   +1 more source

Skrining Bakteri Termohalofilik Penghasil L-asparaginase dari Sumber Air Panas Wawolesea Sulawesi Tenggara dan Uji Aktivitas Enzimnya

Alchemy
L-asparaginase merupakan enzim yang mengubah L-asparagin menjadi L-aspartat. L-asparagin dapat dimanfaatkan oleh sel kanker leukemia sebagai salah satu sumber nutrisinya. Penambahan L-asparaginase dapat menghambat pertumbuhan sel kanker.
Muzuni Muzuni, Jamaluddin Jamaluddin, Suriana Suriana, Ardiansyah Ardiansyah, Nur Arfa Yanti   +4 more
doaj   +1 more source

Recombinant L-Asparaginase from Zymomonas mobilis: A Potential New Antileukemic Agent Produced in Escherichia coli. [PDF]

PLoS ONE, 2016
L-asparaginase is an enzyme used as a chemotherapeutic agent, mainly for treating acute lymphoblastic leukemia. In this study, the gene of L-asparaginase from Zymomonas mobilis was cloned in pET vectors, fused to a histidine tag, and had its codons ...
Karen Einsfeldt, Isis Cavalcante Baptista, Juliana Christina Castanheira Vicente Pereira, Isabele Campos Costa-Amaral, Elaine Sobral da Costa, Maria Cecília Menks Ribeiro, Marcelo Gerardin Poirot Land, Tito Lívio Moitinho Alves, Ariane Leites Larentis, Rodrigo Volcan Almeida   +9 more
doaj   +1 more source

Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]

, 2018
In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta, Bianchi, Massimiliano G., Bussolati, Ovidio, Chiu, Martina, Ciociola, Tecla, Lagrasta, Costanza A M, Ottaviani, Laura, Tardito, Saverio, Taurino, Giuseppe   +8 more
core   +2 more sources

Effect of dose and schedule of L-asparaginase administration on early minimal residual disease in acute lymphoblastic leukemia

Indian Journal of Medical and Paediatric Oncology, 2019
Background and Objectives: L-asparaginase has become the backbone of acute lymphoblastic leukemia induction. In Berlin–Frankfurt–Munster (BFM) 95/2000 protocols, L-asparaginase was given twice weekly for initial 4 weeks.
Satyanker Gupta, Amit Sehrawat, Ketan Dang, Lalit Sharma, Sarita R. Jaiswal, Suparno Chakarbarti   +5 more
doaj   +1 more source

Production, characterization and bioinformatics analysis of l-asparaginase from a new Stenotrophomonas maltophilia EMCC2297 soil isolate

AMB Express, 2020
An exhaustive screening program was applied for scoring a promising l-asparaginase producing-isolate. The recovered isolate was identified biochemically and molecularly and its l-asparaginase productivity was optimized experimentally and by Response ...
Nada A. Abdelrazek, Walid F. Elkhatib, Marwa M. Raafat, Mohammad M. Aboulwafa   +3 more
doaj   +1 more source

Anticancer L-Asparaginase and Phytoactive Compounds From Plant Against MDR (Methicillindrug resistant) and Fungal Isolates

Dose-Response, 2022
L-asparaginase is used in chemotherapy for acute lymphoblastic leukemia and other cancers. L-asparaginase derived from bacterial source triggers immune responses.
Ambreen Aisha, Saba Zahra, Imtiaz M. Tahir, Asim Hussain, Naheed Bano, Alishbah Roobi, Nadia Afsheen, Yasir Saleem   +7 more
doaj   +1 more source

Glutamine Phosphoribosylpyrophosphate Amidotransferase-independent Phosphoribosyl Amine Synthesis from Ribose 5-Phosphate and Glutamine or Asparagine [PDF]

, 2007
Phosphoribosylamine (PRA) is the first intermediate in the common pathway to purines and thiamine and is generated in bacteria by glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase (EC 2.4.2.14) from PRPP and glutamine.
Downs, Diana M., Koenigsknecht, Mark J., Ramos, Itzel   +2 more
core   +2 more sources

Characterization and Optimization of Fungal L-Asparaginase Isolated From Soil and Medicinal Plants

Journal of Pure and Applied Microbiology, 2022
L-asparaginase is a therapeutic enzyme that converts L-asparagine into ammonia and L-aspartate. L-asparaginase is used to treat acute lymphoblastic leukaemia. In food manufacturing industries, it is used to inhibit the acrylamide formation.
S. Ranjini Priya, A. Subhashini
doaj   +1 more source

Preliminary study for the preparation of fatty acid bioconjugated L-asparaginase micellar nanocarrier as a delivery system for peptide anti-cancer agents [PDF]

Trends in Pharmaceutical Sciences, 2020
In the present study, the mixing behavior of different groups of surfactants and fatty acid bioconjugated L-asparaginase investigated. The amphiphilic macromolecules were achieved by covalent linkage of fatty acids with different chain lengths (C12, C16,
Hajar Ashrafi, amir Azadi, Soliman Mohammadi-Samani, Younes Ghasemi, Saeid** Daneshamouz   +4 more
doaj   +1 more source