Results 61 to 70 of about 22,679 (205)

Uji Antikanker Isolat Bioaktif L-Asparaginase dari Kunyit Putih (Curcuma mangga Val.) terhadap Sel Kanker Serviks

open access: yesJurnal Kimia Sains dan Aplikasi, 2011
Kunyit putih (Curcuma mangga Val.) merupakan salah satu sumber L-asparaginase yang berpotensi sebagai bioaktif antikanker. Tujuan penelitian ini adalah untuk menentukan nilai LC50 dan potensi antikanker enzim L-asparaginase dari kunyit putih pada kultur ...
Citrawati Octavia Suprobo   +2 more
doaj   +1 more source

Optimization of Physiological Growth Conditions for Maximal Production of L-Asparaginase by Fusarium Species [PDF]

open access: yes, 2015
L-asparaginase is an enzyme which catalyzes the hydrolysis of amino acid L-asparagine to L-aspartic acid and ammonia. Due to its utility in pharmaceutical as well as food industries, there has been a paramount interest on the production of this enzyme ...
Anil kumar Meghavarnam, .   +1 more
core  

From Power‐Law to Correlation‐Time Distributions: A Unified Framework for the Analysis of Nuclear Magnetic Relaxation Dispersion (NMRD) Profiles of Complex Biological Systems

open access: yesMagnetic Resonance in Chemistry, EarlyView.
1H NMRD profiles of biological systems often follow a power‐law dependence rather than a Lorentzian dispersion. This behavior can arise from a broad distribution of correlation times, weighted by 1/τ 1−α. Validated across diverse systems such as sedimented proteins and biological tissues, this framework provides a physical interpretation of power‐law ...
Giacomo Parigi, Adam Kubrak
wiley   +1 more source

PURIFICATION AND IMMOBILIZATION OF L-ASPARAGINASE ENZYME FROM THE THERMOPHILIC BACTERIA Bacillus licheniformis STRAIN HSA3-1a [PDF]

open access: yes
L-Asparaginase gives a great benefit in the cancer treatment, especially in acute\ud lymphoblastic leukemia. L-Asparaginase is also proven to reduce the acrylamide\ud content in the foods.
Natsir, Hasnah
core   +3 more sources

Isolation and Purification of L-Asparaginase from Persian Gulf Streptomyces Isolates and Evaluation of It’s Cloned Gene Expression in Escherichia Coli by Real-Time and SDS-PAGE [PDF]

open access: yesJournal of Advanced Biomedical Sciences, 2020
Background & Objective: Asparaginase enzymes are effective in treating lymphoblastic leukemia cancer. This enzyme is isolated from bacterial sources and commercially available as an anticancer drug.
Hadiseh Soofer   +2 more
doaj  

Optimization of physiological conditions for L-asparaginase production by endophytic fungi (Fusarium solani) isolated from Tinospora cordifolia (Willd.) Hook. F & Thomson [PDF]

open access: yes, 2016
Asparaginase converts L-asparagine to L-aspartic acid and has received considerable attention in the recent years for its anti-carcinogenic potential. In the present investigation, the endophytic fungi isolated from T.
Fazilath Uzma, .   +2 more
core  

L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors [PDF]

open access: yes, 2015
Bacteria can be engineered to deliver anticancer proteins to tumors via a controlled expression system that maximizes the concentration of the therapeutic agent in the tumor. L-asparaginase (L-ASNase), which primarily converts asparagine to aspartate, is
Choy, Hyon E.   +11 more
core   +2 more sources

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

open access: yesJournal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes   +2 more
wiley   +1 more source

A Comparative Study on Pseudomonal and Bacillus L. asparaginases

open access: yesJournal of Pure and Applied Microbiology, 2019
The enzyme L-asparaginase is commonly used in treatment of acute lymphoblastic leukemia (ALL). Due to its therapeutic importance and growing demands in medical and food industry much of the research have been focused to produce this enzyme with better ...
Nuzhath Fatima   +5 more
doaj   +1 more source

Chemotherapy‐driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia

open access: yesBritish Journal of Haematology, EarlyView.
Chemotherapy‐induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross‐talk and restores therapeutic response, highlighting WNT inhibitors as a promising strategy to prevent relapse in ALL.
Foteini Kalampalika   +4 more
wiley   +1 more source

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