Results 81 to 90 of about 22,679 (205)

Metabolic Enzyme MeHNL11 Regulates MeCAS1b Transcription for Cyanide Reutilization in Response to Nitrate Deficiency in Cassava

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cassava (Manihot esculenta Crantz) exhibits exceptional tolerance to infertile soils and contains abundant cyanogenic glucosides (CGs). Previous research has indicated that CGs can serve as a significant reservoir of organic nitrogen in plants.
Weitao Mai, Ruxue Bao, Xiaocheng Liu, Mengtao Li, Jinling Zhao, Huaifang Zhang, Yuan Yao, Haiyan Wang, Wenquan Wang, Changying Zeng, Xin Chen   +10 more
wiley   +1 more source

Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen

eJHaem, 2023
PEG‐asparaginase is used as a treatment for Philadelphia‐negative acute lymphoblastic leukemia. In pediatric studies, triglycerides (TGs) were affected more by PEG‐asparaginase than by native L‐asparaginase (10.0% vs. 5.5%).
Ibrahim Al Nabhani, Claire Andrews, Jad Sibai, Eshetu Atenafu, Taylor Young, Steven M. Chan, Vikas Gupta, Dawn Maze, Aaron D. Schimmer, Andre C. Schuh, Karen Yee, Hassan Sibai   +11 more
doaj   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Solid-phase enzyme modification via affinity chromatography [PDF]

, 2003
In the present study antileukemic enzyme L-asparaginase (ASNase) and catalase (as a model enzyme) were modified in solid-phase with activated polyethylene glycol (PEG ) by using ligand-immobilized affinity column systems L-asparagine- 2 Sepharose CL-4B
Aebi, Berg, Blanco, Butterfield, Fortier, Fusek, Greenwald, Inada, Jayaram, Jorge, Jouve, Kodera, Kurtzberg, Lee, Lentsch, Lowry, Martinez, Matsushima, Mumtaz, Ono, Petkov, Qian, Qian, Smith, Soares, Stelwagen, Swain, Turkova, Turkova, Turkova, Wissink, Wriston, Yoshimoto   +32 more
core   +1 more source

Selumetinib as an Effective Therapy of Histiocytic Sarcoma Evolving From a B‐Cell Acute Lymphoblastic Leukaemia

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Histiocytic sarcoma (HS) is a rare neoplasm derived from non‐Langerhans histiocytic cells, exceptionally arising from B‐ALL. Methods We present the case of a child with high‐risk B‐ALL with PAX5 P80R mutation. Results Despite initial remission, a chemoresistant paravertebral mass was identified as HS.
Laetitia Largeaud, Charlotte Syrykh, Julie Vial, Alban Canali, Isabelle Luquet, François Vergez, Stéphanie Dufrechou, Naïs Prade, André Baruchel, Bastien Gerby, Marie Nolla, Eric Delabesse, Marlène Pasquet   +12 more
wiley   +1 more source

Incidence and Risk Factors of Symptomatic Osteonecrosis in Children With Acute Lymphoblastic Leukemia—A Population‐Based Analysis of the Austrian ALL‐BFM Study Group

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Background Osteonecrosis is a clinically relevant therapy‐associated complication in pediatric acute lymphoblastic leukemia (ALL). Methods In a nationwide Austrian cohort of 1127 patients with newly diagnosed ALL treated on AIEOP‐BFM‐ALL 2000 and 2009 protocols, 73 patients developed symptomatic osteonecrosis.
Katharina Arnold, Leila Ronceray, Martin Benesch, Roman Crazzolara, Michael Dworzak, Gernot Engstler, Anna Füreder, Neil Jones, Reinhold Kerbl, Paulina Kurzmann, Bernhard Meister, Ulrike Pötschger, Fiona Poyer, Hannah von Mersi, Christian Urban, Barbara Winkler, Andishe Attarbaschi, the Austrian Berlin‐Frankfurt‐Münster (BFM) Study Group   +17 more
wiley   +1 more source

Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice

Journal of Pharmacological Sciences, 2018
Proliferation of acute lymphoblastic leukemic cells is nutritionally dependent on the external supply of asparagine. l-asparaginase, an enzyme hydrolyzing l-asparagine in blood, is used for treatment of acute lymphoblastic leukemic and other related ...
Shoya Shiromizu, Naoki Kusunose, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo   +4 more
doaj   +1 more source

Absence of anti-neocarzinostatin (NCS) antibody production in leukemia patients treated with NCS [PDF]

, 1976
Neocarzinostain (NCS) was first used by Hiraki and his colleagues for induction chemotherapy in acute leukemia. This new anti-tumor agent is a polypeptide with a high molecular weight of 10,700 daltons.
Toki, Hironobu
core   +1 more source

Multiomics Research Strategies in Cancer: A Growing and Innovative Field

MedComm, Volume 7, Issue 4, April 2026.
This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du, Xiaomei Liu, Zhi Lv, Bengang Wang, Yu Xia, Wala Abduljabbar Mohammed Al‐Duais, Lirong Yan, Fuqiang Zhang, Yanke Li   +8 more
wiley   +1 more source

The use of asparaginase to reduce acrylamide levels in cooked food [PDF]

, 2016
Strategies proposed for reducing the formation of the suspected carcinogen acrylamide in cooked foods often rely on a reduction in the extent of the Maillard reaction, in which acrylamide is formed from the reaction between asparagine and reducing sugars.
Elmore, J. Stephen, Oruna-Concha, Maria-Jose, Xu, Fei   +2 more
core   +1 more source