Results 51 to 60 of about 13,200,542 (201)

Analytical and physicochemical characterisation of the senile cataract drug dipeptide [Beta]-alanyl-L-histidine (carnosine) [PDF]

open access: yes, 2015
This study presents a simple but sensitive HPLC chromatographic method with a stability-indicating assay for determination and physicochemical characterisation of L-carnosine, a promising senile cataract prophylactic agent.
Abdelkader, Hamdy   +7 more
core   +1 more source

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

open access: yesCell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu   +15 more
wiley   +1 more source

Molecular identification of carnosine N-methyltransferase as chicken histamine N-methyltransferase-like protein (hnmt-like).

open access: yesPLoS ONE, 2013
Anserine (beta-alanyl-N(Pi)-methyl-L-histidine), a naturally occurring derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of skeletal muscles and brain of many vertebrates.
Jakub Drozak   +4 more
doaj   +1 more source

EFFECT OF Β-ALANINE AND L-HISTIDINE ON CONCENTRATION OF CARNOSINE IN MUSCLE TISSUE AND OXIDATIVE STABILITY OF CHICKEN MEAT [PDF]

open access: yesPoljoprivreda, 2015
This paper presents the results of two separate experiments, each involving 75 chickens of Cobb 500 provenience, divided into three experimental groups.
Gordana Kralik   +5 more
doaj   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

open access: yesThe FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah   +5 more
wiley   +1 more source

Influence of Dietary Histidine, Hybrid Line and Gender on Chicken Meat Quality and Carnosine Concentration

open access: yesThe Journal of Poultry Science, 2015
The aim of the investigation was to determine influence of L-histidine dietary supplementation (P1 0.0%, P2 0.1%, P3 0.2% and P4 0.3%), hybrid line (Cobb 500 and Hubbard Classic) and gender on meat quality and carnosine concentration in chicken breast ...
Gordana Kralik   +4 more
doaj   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

open access: yesThe FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe   +5 more
wiley   +1 more source

Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?

open access: yesFrontiers in Nutrition, 2019
Carnosine is an abundant histidine-containing dipeptide in human skeletal muscle and formed by beta-alanine and L-histidine. It performs various physiological roles during exercise and has attracted strong interest in recent years with numerous ...
Pedro Perim   +8 more
doaj   +1 more source

Virocell Necromass Provides Limited Plant Nitrogen and Elicits Rhizosphere Metabolites That Affect Phage Dynamics

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Bacteriophages impact soil bacteria through lysis, altering the availability of organic carbon and plant nutrients. However, the magnitude of nutrient uptake by plants from lysed bacteria remains unknown, partly because this process is challenging to investigate in the field.
Vlastimil Novak   +10 more
wiley   +1 more source

Effect of Levo-Carnosine on Biomarkers of Oxidative Stress and Hepatotoxicity in Cisplatin-Treated Male Sprague Dawley Rats

open access: yesPakistan Armed Forces Medical Journal, 2022
Objective: To determine the effect of Levo-Carnosine on biomarkers of oxidative stress and hepatocellular damage in cisplatin-treated rats. Study Design: Laboratory based experimental study.
Sajid Ali   +5 more
doaj   +2 more sources

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