Results 1 to 10 of about 31,622 (258)

Impact of l‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells [PDF]

Pulmonary Circulation, 2023
Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l‐arginine precursor, l‐citrulline, improves NO signaling and has therapeutic potential in PH.
Matthew S. Douglass, Mark R. Kaplowitz, Yongmei Zhang, Candice D. Fike   +3 more
doaj   +4 more sources

Modification of substrate specificity of l-arginine oxidase for detection of l-citrulline [PDF]

AMB Express, 2023
Enzymatic detection of citrulline, a potential biomarker for various diseases, is beneficial. However, determining citrulline levels requires expensive instrumental analyses and complicated colorimetric assays. Although l-amino acid oxidase/dehydrogenase
Kei Yamamoto, Yosuke Masakari, Yasuko Araki, Atsushi Ichiyanagi, Kotaro Ito   +4 more
doaj   +2 more sources

Anti-nociceptive Activity of L-citrulline in Mice Using Formalin and Hot Plate Tests: Possible Mechanism of Action [PDF]

Avicenna Journal of Medical Biochemistry, 2022
Background: Peripheral pain regulation is a very complex phenomenon due to the numerous neural pathways responsible for it. Objectives: The current study aimed to determine the anti-nociceptive activity of L-citrulline and the possible role of ...
Pegah Haramipour, Shahin Hassanpour
doaj   +3 more sources

L-Citrulline Supplementation and Exercise in the Management of Sarcopenia [PDF]

Nutrients, 2021
Sarcopenia is a process associated to aging. Persistent inflammation and oxidative stress in muscle favour muscle wasting and decreased ability to perform physical activity. Controlled exercise can optimize blood flux and moderate the production of reactive oxygen species.
Alberto Caballero-García, Jorge Pascual-Fernández, David C. Noriega, Hugo J. Bello, Antoni Pons, Enrique Roche, Alfredo Córdova   +6 more
openalex   +5 more sources

L-Citrulline Improves Recovery of Enterocytes While Not Affecting Gut Microbiota in an In Vitro Model of Chemotherapy-Induced Gastrointestinal Mucositis [PDF]

Biomedicines
Background/Objectives: Despite significant advancements in cancer treatment outcomes, side effects, such as gastrointestinal mucositis (GIM), continue to impair patients’ quality of life.
Wally van der Laan, Pablo A. Gallardo Molina, Debby P. Y. Koonen, Hermie J. M. Harmsen, Wim J. E. Tissing   +4 more
doaj   +2 more sources

Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence. [PDF]

PLoS ONE, 2018
L-citrulline and L-arginine supplementation has been shown to have several beneficial effects on the cardiovascular system. Nitric oxide (NO) protects against the progression of atherosclerosis and is synthesized by nitric oxide synthase (NOS), which ...
Tomoe Tsuboi, Morihiko Maeda, Toshio Hayashi   +2 more
doaj   +4 more sources

The effects of L-Citrulline and Glutathione on Endurance performance in young adult trained males [PDF]

Journal of the International Society of Sports Nutrition, 2023
Background Citrulline may amplify the effects of L-arginine and nitric oxide concentration, which may augment vasodilation and blood flow, thereby enhancing aerobic exercise performance.
Hannah E. Cabre, Casey E. Greenwalt, Lacey M. Gould, Abbie E. Smith-Ryan   +3 more
doaj   +2 more sources

Dose-response effect of L-citrulline on skeletal muscle damage after acute eccentric exercise: an in vivo study in mice [PDF]

PeerJ, 2023
Background Eccentric exercise may trigger mechanical stress, resulting in muscle damage that may decrease athletic performance. L-citrulline potentially prevents skeletal muscle damage after acute eccentric exercise.
Dhoni Akbar Ghozali, Muchsin Doewes, Soetrisno Soetrisno, Dono Indarto, Muhana Fawwazy Ilyas   +4 more
doaj   +3 more sources

Assessment of Registered Clinical Trial Designs: Comparison of L-Arginine and/or L-Citrulline Interventions for Hypertension [PDF]

Pharmaceuticals
Background: L-Arginine (Arg) is an essential amino acid and a precursor for the synthesis of vascular nitric oxide, while L-Citrulline is a non-essential amino acid substrate for increasing L-arginine.
Ashley Brett Hillsley, Craig Steven McLachlan   +1 more
doaj   +2 more sources

L-Citrulline in Neonates: From Bench to Bed Side. [PDF]

Children (Basel)
L-citrulline (L-CIT), a precursor to L-arginine (L-ARG), is a key contributor to the nitric oxide (NO) signaling pathway. Endothelial dysfunction, characterized by deficient nitric oxide synthesis, is implicated in the pathogenesis of various neonatal conditions such as necrotizing enterocolitis (NEC) and bronchopulmonary dysplasia (BPD) associated ...
Mascarenhas D, Mohammadi A, Higazy R, Ivanovska J, Gauda E, Jasani B.   +5 more
europepmc   +3 more sources