Results 1 to 10 of about 30,781 (139)

Modification of substrate specificity of l-arginine oxidase for detection of l-citrulline [PDF]

AMB Express, 2023
Enzymatic detection of citrulline, a potential biomarker for various diseases, is beneficial. However, determining citrulline levels requires expensive instrumental analyses and complicated colorimetric assays. Although l-amino acid oxidase/dehydrogenase
Kei Yamamoto, Yosuke Masakari, Yasuko Araki, Atsushi Ichiyanagi, Kotaro Ito   +4 more
doaj   +2 more sources

Impact of l‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells [PDF]

Pulmonary Circulation, 2023
Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l‐arginine precursor, l‐citrulline, improves NO signaling and has therapeutic potential in PH.
Matthew S. Douglass, Mark R. Kaplowitz, Yongmei Zhang, Candice D. Fike   +3 more
doaj   +2 more sources

L-Citrulline Improves Recovery of Enterocytes While Not Affecting Gut Microbiota in an In Vitro Model of Chemotherapy-Induced Gastrointestinal Mucositis [PDF]

Biomedicines
Background/Objectives: Despite significant advancements in cancer treatment outcomes, side effects, such as gastrointestinal mucositis (GIM), continue to impair patients’ quality of life.
Wally van der Laan, Pablo A. Gallardo Molina, Debby P. Y. Koonen, Hermie J. M. Harmsen, Wim J. E. Tissing   +4 more
doaj   +2 more sources

The effects of L-Citrulline and Glutathione on Endurance performance in young adult trained males [PDF]

Journal of the International Society of Sports Nutrition, 2023
Background Citrulline may amplify the effects of L-arginine and nitric oxide concentration, which may augment vasodilation and blood flow, thereby enhancing aerobic exercise performance.
Hannah E. Cabre, Casey E. Greenwalt, Lacey M. Gould, Abbie E. Smith-Ryan   +3 more
doaj   +2 more sources

Dose-response effect of L-citrulline on skeletal muscle damage after acute eccentric exercise: an in vivo study in mice [PDF]

PeerJ, 2023
Background Eccentric exercise may trigger mechanical stress, resulting in muscle damage that may decrease athletic performance. L-citrulline potentially prevents skeletal muscle damage after acute eccentric exercise.
Dhoni Akbar Ghozali, Muchsin Doewes, Soetrisno Soetrisno, Dono Indarto, Muhana Fawwazy Ilyas   +4 more
doaj   +3 more sources

Assessment of Registered Clinical Trial Designs: Comparison of L-Arginine and/or L-Citrulline Interventions for Hypertension [PDF]

Pharmaceuticals
Background: L-Arginine (Arg) is an essential amino acid and a precursor for the synthesis of vascular nitric oxide, while L-Citrulline is a non-essential amino acid substrate for increasing L-arginine.
Ashley Brett Hillsley, Craig Steven McLachlan   +1 more
doaj   +2 more sources

Effects of dietary L-Citrulline supplementation on growth performance, meat quality, and fecal microbial composition in finishing pigs [PDF]

Frontiers in Microbiology, 2023
Gut microbiota play an important role in the gut ecology and development of pigs, which is always regulated by nutrients. This study investigated the effect of L-Citrulline on growth performance, carcass characteristics, and its potential regulatory ...
Junhua Du, Junhua Du, Mailin Gan, Mailin Gan, Zhongwei Xie, Zhongwei Xie, Chengpeng Zhou, Chengpeng Zhou, Yunhong Jing, Yunhong Jing, Menglin Li, Menglin Li, Chengming Liu, Chengming Liu, Meng Wang, Meng Wang, Haodong Dai, Haodong Dai, Zhiyang Huang, Zhiyang Huang, Lei Chen, Lei Chen, Ye Zhao, Ye Zhao, Lili Niu, Lili Niu, Yan Wang, Yan Wang, Shunhua Zhang, Shunhua Zhang, Zongyi Guo, Linyuan Shen, Linyuan Shen, Li Zhu, Li Zhu   +34 more
doaj   +2 more sources

Impact of dietary supplementation of L-citrulline to meat goats during gestation on reproductive performance [PDF]

Journal of Animal Science and Biotechnology
Background Meat goat production is a worldwide industry with products such as meat, milk, soap, and fiber being produced. There are approximately 2.6 million meat goats in the United States.
Makenzie G. Newton, Arianna N. Lopez, Claire Stenhouse, Karina L. Hissen, Erin D. Connolly, Xingchi Li, Lan Zhou, Guoyao Wu, William B. Foxworth, Fuller W. Bazer   +9 more
doaj   +2 more sources

Palmitic acid-induced cell death: impact of endoplasmic reticulum and oxidative stress, mitigated by L-citrulline [PDF]

Animal Bioscience
Objective Palmitic acid (PA), the most abundant saturated free fatty acids, induces apoptosis in bovine mammary epithelial cells (MECs). It is suggested that oxidative stress and endoplasmic reticulum (ER) stress are key mechanisms underlying PA-induced ...
Md. Rezwanul Habib, Yukako Tokutake, Shinichi Yonekura   +2 more
doaj   +2 more sources

Oral administration of l-citrulline alters the vascular delivery of substances to rat skeletal muscles

Biochemistry and Biophysics Reports, 2021
Vascular endothelial function deteriorates with age and disease, and the production of vasodilator factors like nitric oxide (NO) decreases. The free amino acid l-citrulline increases vasodilation and blood flow through increased NO production.
Sho Miyatake, Kazuo Hino, Goro Ebisu, Satoshi Fujita   +3 more
doaj   +1 more source