Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence. [PDF]
PLoS ONE, 2018 L-citrulline and L-arginine supplementation has been shown to have several beneficial effects on the cardiovascular system. Nitric oxide (NO) protects against the progression of atherosclerosis and is synthesized by nitric oxide synthase (NOS), which ...
Tomoe Tsuboi +2 more
doaj +4 more sources
L-Citrulline Supplementation and Exercise in the Management of Sarcopenia [PDF]
Nutrients, 2021 Sarcopenia is a process associated to aging. Persistent inflammation and oxidative stress in muscle favour muscle wasting and decreased ability to perform physical activity. Controlled exercise can optimize blood flux and moderate the production of reactive oxygen species.
Alberto Caballero-García +6 more
openaire +3 more sources
Optimization of L-Citrulline Operon in Corynebacterium glutamicum for L-Citrulline Production
Processes, 2022 L-citrulline plays important roles in many physiological processes, and its application range is expanding rapidly. Corynebacterium glutamicum strains have the potential to be efficient L-citrulline producers. In this study, we performed optimization of L-citrulline biosynthesis operon in C. glutamicum ATCC13032 for L-citrulline production. Chromosomal
Zaiwei Man +4 more
openaire +1 more source
Anti-nociceptive Activity of L-citrulline in Mice Using Formalin and Hot Plate Tests: Possible Mechanism of Action [PDF]
Avicenna Journal of Medical Biochemistry, 2022 Background: Peripheral pain regulation is a very complex phenomenon due to the numerous neural pathways responsible for it. Objectives: The current study aimed to determine the anti-nociceptive activity of L-citrulline and the possible role of ...
Pegah Haramipour, Shahin Hassanpour
doaj +1 more source
Pulmonary Circulation, 2021 The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Matthew S. Douglass +3 more
doaj +1 more source
L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism. [PDF]
PLoS ONE, 2015 Dietary L-citrulline is thought to modulate muscle protein turnover by increasing L-arginine availability. To date, the direct effects of increased L-citrulline concentrations in muscle have been completely neglected. Therefore, we determined the role of
Daniel J Ham +6 more
doaj +1 more source
l-Citrulline Supplementation: Impact on Cardiometabolic Health [PDF]
Nutrients, 2018 Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in the regulation of numerous vital biological functions, contributes to the development and progression of multiple age- and lifestyle-related diseases. While l-arginine is the precursor for the synthesis of NO by endothelial-nitric oxide synthase (eNOS), oral l ...
Timothy Allerton +5 more
openaire +2 more sources
Sodium-coupled neutral amino acid transporter 1 (SNAT1) modulates L-citrulline transport and nitric oxide (NO) signaling in piglet pulmonary arterial endothelial cells. [PDF]
PLoS ONE, 2014 There is evidence that impairments in nitric oxide (NO) signaling contribute to chronic hypoxia-induced pulmonary hypertension. The L-arginine-NO precursor, L-citrulline, has been shown to ameliorate pulmonary hypertension.
Anna Dikalova +5 more
doaj +1 more source
Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. [PDF]
PLoS ONE, 2012 BACKGROUND: Impaired microcirculation during endotoxemia correlates with a disturbed arginine-nitric oxide (NO) metabolism and is associated with deteriorating organ function.
Karolina A P Wijnands +6 more
doaj +1 more source
Heliyon, 2021 In our previous study, we found that the vasodilation of retinal arterioles induced by acetylcholine and BMS-191011, a large-conductance Ca2+-activated K+ (BKCa) channel opener, were diminished in diabetic rats.
Asami Mori +7 more
doaj +1 more source