Results 51 to 60 of about 13,339,760 (194)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Asymmetric dimethylarginine predicts perioperative cardiovascular complications in patients undergoing medium-to-high risk non-cardiac surgery

Journal of International Medical Research, 2020
Objectives Perioperative cardiovascular events remain an important factor that affects surgery outcome. We assessed if asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, predicts perioperative risk, and if pre ...
Daniel Appel, Rainer Böger, Julia Windolph, Gina Heinze, Alwin E. Goetz, Juliane Hannemann   +5 more
doaj   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

L-Arginine Synthesis from L-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo

, 2019
Immunonutrition as a therapeutic approach is rapidly gaining interest in the fight against infection. Targeting L-arginine metabolism is intriguing, considering this amino acid is the substrate for antimicrobial NO production by macrophages.
McKell, Melanie C., Green, Lisa C., Lange, Shannon M., Kohler, S. Eleonore, Qualls, Joseph E., Schmidt, Stephanie M., Schlesinger, Larry S., Setchell, Kenneth D. R., Zhao, Junfang, Kohler, S. Eleonore; id_orcid, Arnett, Eusondia, Bricker, Rebecca L., Crowther, Rebecca R.   +12 more
core   +1 more source

L-citrulline production by metabolically engineered Corynebacterium glutamicum from glucose and alternative carbon sources [PDF]

, 2014
Eberhardt D, Vold Korgaard Jensen J, Wendisch VF. L-citrulline production by metabolically engineered Corynebacterium glutamicum from glucose and alternative carbon sources. AMB Express.
Dorit Eberhardt, Vold Korgaard Jensen, Jaide, Wendisch, Volker F. ; https://orcid.org/, Volker F Wendisch, Jaide V K Jensen, Eberhardt, Dorit   +5 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Effects of dietary L-Citrulline supplementation on growth performance, meat quality, and fecal microbial composition in finishing pigs

Frontiers in Microbiology, 2023
Gut microbiota play an important role in the gut ecology and development of pigs, which is always regulated by nutrients. This study investigated the effect of L-Citrulline on growth performance, carcass characteristics, and its potential regulatory ...
Junhua Du, Junhua Du, Mailin Gan, Mailin Gan, Zhongwei Xie, Zhongwei Xie, Chengpeng Zhou, Chengpeng Zhou, Yunhong Jing, Yunhong Jing, Menglin Li, Menglin Li, Chengming Liu, Chengming Liu, Meng Wang, Meng Wang, Haodong Dai, Haodong Dai, Zhiyang Huang, Zhiyang Huang, Lei Chen, Lei Chen, Ye Zhao, Ye Zhao, Lili Niu, Lili Niu, Yan Wang, Yan Wang, Shunhua Zhang, Shunhua Zhang, Zongyi Guo, Linyuan Shen, Linyuan Shen, Li Zhu, Li Zhu   +34 more
doaj   +1 more source

CHronic hypERtension and L-citRulline studY (CHERRY): an Early-Phase Randomised Controlled Trial in Pregnancy. [PDF]

Reprod Sci, 2023
Oral supplementation with L-citrulline, which is sequentially converted to L-arginine then nitric oxide, improves vascular biomarkers and reduces blood pressure in non-pregnant, hypertensive human cohorts and pregnant mice with a pre-eclampsia-like ...
Ormesher L, Worton SA, Best A, Dodd SR, Dempsey A, Cottrell EC, Glossop H, Chmiel C, Wu HY, Hardwick B, Hennessy S, Johnstone ED, Myers JE.   +12 more
europepmc   +2 more sources