Results 91 to 100 of about 13,194,872 (182)

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Isolation and screening of l-asparaginase free of glutaminase and urease from fungal sp. [PDF]

, 2016
l-Asparaginase is a chemotherapeutic drug used in the treatment of acute lymphoblastic leukaemia (ALL), a malignant disorder in children. l-Asparaginase helps in removing acrylamide found in fried and baked foods that is carcinogenic in nature.
Devarai, S K, Doriya, K, Devarai, Santhosh Kumar   +2 more
core   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Supplementary Data from A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo

, 2018
Supplementary methods Supplementary Text: Wolinella succinogenes as a low L-glutaminase L-asparaginase Supplementary Figures: •Fig. S1. In vivo imaging showing that the L-glutaminase-diminished ErA-63Q and ErA-DM variants eliminate T-ALL LOUCY cells as
Michael J. Schlicht (12573811), Veerle Mondelaers (14929506), Jenny Y. Zhang (7944023), Damiano Rondelli (6029567), Hien Anh Nguyen (1748419), Amanda M. Schalk (14929503), Aleksandar Antanasijevic (475614), Alexander V. Lyubimov (3753862), Andre Kajdacsy-Balla (2861), Michael Caffrey (151843), Dolores L. Mahmud (14927913), Bradley J. Merrill (7944032), Yogen Saunthararajah (320626), Arnon Lavie (307968), Li Liu (75607), Pieter Van Vlierberghe (367942), Sofie Peirs (7860863), Barbara De Moerloose (9512058), Annie Oh (3273087), Maarten C. Bosland (7921751), Ying Su (206940), Kasim K. Kabirov (3753859), Tim Lammens (184580), Steven Goossens (426910)   +23 more
core   +1 more source

Molecular characterization and computational analysis of a highly specific L-glutaminase from a marine bacterium Bacillus australimaris NIOT30

Scientific Reports
An alkaline active L-glutaminase (BALG) producing bacterium was screened and identified from seamount sediment samples of the Arabian Sea. The isolate was confirmed to be Bacillus australimaris NIOT30 based on morphological characteristics and 16 S rRNA ...
Nishanthika Thenmozhi Kulasekaran, Vanlalrovi, Lenin Subramanian, Jung-Kul Lee, Dharani Gopal, Jeya Marimuthu   +5 more
doaj   +1 more source

Screening of Bacteria Producing Asparaginase Free of Glutaminase and Urease from Hot Springs in West Sulawesi

Biosaintifika: Journal of Biology & Biology Education, 2019
L-asparaginase catalyzes the hydrolysis of asparagine into ammonia and aspartate. It has been used in chemotherapy for patients with acute lymphoblastic leukemia. L-asparaginase presents in animal, plant and microorganism.
Ruby Setiawan, Dinar Rahmi Larasati
doaj   +1 more source

miR‐15a‐5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Schematic diagram of the mechanism by which miR‐15a‐5p regulates glioblastoma progression through targeting GLS2 and modulating ferroptosis. miR‐15a‐5p regulates the ferroptosis pathway by targeting and inhibiting glutaminase 2 (GLS2) expression: Downregulation of miR‐15a‐5p leads to upregulation of GLS2, which promotes lipid peroxidation, accompanied ...
Yanyan Yu, Helan Yuan, Zikun Fang, Jinyuan Liao, Yancong Yang, Jun Liu, Wenjin Wei, Qiuhua Jiang   +7 more
wiley   +1 more source

Detection of Pancreatic Cancer via Specific Metabolite Markers: A Metabolomics Approach

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies worldwide because most patients are diagnosed at advanced stages when curative treatment is no longer feasible. Metabolomics has emerged as a promising strategy for identifying biochemical alterations associated with early tumor development ...
Mohammad Javad Roustaye Gourabi, Mehrangiz Ghafari, Anita Nikoo, Yalda Yarahmadi Saki, Bita Khanbabaei, Masoumeh Khanizadeh, Masoud Kargar, Ali Hashemi, Javad Yasbolaghi Sharahi   +8 more
wiley   +1 more source

Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells

, 2017
Glutaminolysis that catabolizes glutamine to glutamate plays a critical role in cancer progression. Glutaminase 2 (GLS2) has been reported as a tumor suppressor.
Kuo, Tsang-Chih;Chen, Chi-Kuan;Hua, Kuo-Tai;Yu, Pei;Lee, Wei-Jiunn;Chen, Min-Wei;Jeng, Yung-Ming;Chien, Ming-Hsien;Kuo, Kuang-Tai;Hsiao, Michael;Kuo, Min-Liang, 華國泰;鄭永銘   +1 more
core   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source