Results 71 to 80 of about 13,194,872 (182)

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

ROLE OF CARBON SOURCE FOR THE PRODUCTION OF L-GLUTAMINASE FROM ASPERGILLUS ORYZAE

, 2014
Microbial glutaminases are more stable than plant and animal counterparts. In addition to it, they have also been detected in mammalian tissues where they are the major enzymes responsible for catabolic breakdown of glutamine. This study were taken up to
Siddalingeshwara, K G, Saroj, Yadava, PLNSN, Sunil Dutt, Naveen, M   +3 more
core   +1 more source

Therapeutic impact of purified Trichoderma viride l-asparaginase in murine model of liver cancer and in vitro Hep-G2 cell line

Journal of Genetic Engineering and Biotechnology, 2023
Background Hepatocellular carcinoma (HCC) is among the common cancers, but difficult to diagnose and treat. l-asparaginase has been introduced in the treatment protocol of pediatric acute lymphoblastic leukemia (ALL) since the 1960s with a good outcome ...
Dina H. El-Ghonemy, Sanaa A. Ali, Rehab M. Abdel-Megeed, Ali M. Elshafei   +3 more
doaj   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Unravelling the outcome of L-glutaminase produced by Streptomyces sp. strain 5 M as an anti-neoplasm activity

Microbial Cell Factories
Background Actinomycetes are a well-known example of a microbiological origin that may generate a wide variety of chemical structures. As excellent cell factories, these sources are able to manufacture medicines, agrochemicals, and enzymes that are ...
Mervat G. Hassan, Gharieb S. El-Sayyad, Mohamed O. Abdel-Monem, Mohamed N. Malash, Mona A. Kishk, Mohamed E. El Awady, Mohamed I. El-khonezy   +6 more
doaj   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

Production of L-glutaminase and its optimization from a novel marine isolate Vibrio azureus JK-79

, 2016
L-Glutaminase is an amidohydrolase which is produced by a variety of micro-organisms including bacteria, yeast and fungi. It is currently used in the treatment of acute lymphoblastic leukemia (ALL) and human immunodeficiency virus (HIV).
Kiruthika, Jambulingam, Saraswathy, Nachimuthu   +1 more
core   +1 more source

Heterologous production of L-glutaminase through screening and isolation from locally isolated microbes [PDF]

, 2018
L-glutaminase present in living organisms namely human, animals, plants, and microorganisms. L-glutaminase has been identified having potential applications for several industries including pharmaceutical, food, and health care.
Abd Hamid, Hazrulrizawati, Ramli, Aizi Nor Mazila, Tajuddin, Saiful Nizam, Zamri, Normaiza   +3 more
core   +2 more sources

Estimation of L-glutaminase and L-asparaginase activities in soils by the indophenol method [PDF]

Soil Science and Plant Nutrition, 1995
Abstract A simple and rapid method was developed for determining L-glutaminase and L-asparaginase activities in soils. It involved colorimetric estimation of NH4 + released by the activity of L-glutaminase and L-asparaginase when soil was incubated with 0.25 M L-glutamine or L-asparagine in 0.1 M phosphate buffer (pH 7.6) and toluene used as a ...
Shinjiro Kanazawa, Hiromasa Kiyota
openaire   +1 more source

Phenotypic characterization of Arabidopsis thaliana mutants that alleviate root growth defects in a vitamin B6 biosynthesis mutant

The FEBS Journal, EarlyView.
Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra, Paige Henning, Clayton Bailes, Sanja Roje, Hanjo Hellmann   +4 more
wiley   +1 more source