Results 81 to 90 of about 13,194,872 (182)

Optimization of culture conditions for production of L-glutaminase enzyme from Klebsiella pneumoniae [PDF]

The main objective of this study was to investigate the production and activity of glutaminase by some clinical bacterial species. Two marine specimens, saltwater and sediment gathered from the Red Sea coast of Hurghada, Egypt, yielded 100 marine ...
Ibrahim, Asmaa E.M., Elariny, Eman. Y.T., Abdel-Hafez, Lina J.M.   +2 more
core   +1 more source

L-ASPARAGINASE AND L-GLUTAMINASE: SOURCES, PRODUCTION, AND APPLICATIONS IN MEDICINE AND INDUSTRY [PDF]

Journal of microbiology, biotechnology and food sciences, 2019
Amidases (L-asparaginase and L-glutaminase) catalyze the deamination process of L-asparagine and L-glutamine to their corresponding acidic form with ammonia releasing. Both enzymes are considered one of the most biomedical and biotechnologically important groups of enzymes, besides their international contributing as an important commercial products. L-
Hanaa M.Orabi, Esmail M. El-Fakharany, Eman S. Abdelkhalek, Nagwa M. Sidkey   +3 more
openaire   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Keragaman Bakteri Endofit Penghasil L-Asparaginase Bebas L-Glutaminase [PDF]

, 2019
Endophytes are potential as a source of active compound producer. Endophytes that is isolated from tropical medicinal plants has been getting attention due to its high biodiversity and active compound producing ability. L-asparaginase is the first enzyme
sulistiyani, tri ratna, kusumawati, dinihari indah   +1 more
core   +1 more source

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

Immunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins   +5 more
wiley   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

ISOLASI DAN KARAKTERISASI L-GLUTAMINASE DARI BAKTERI SIMBION SPONS DAN APLIKASINYA SEBAGAI ANTIMIKROBA [PDF]

, 2015
Enzim yang berasal dari mikroba simbion spons merupakan senyawa bioaktif yang memiliki potensi sebagai bahan obat baru. Penelitian ini bertujuan untuk mengetahui potensi antimikroba L-Glutaminase dari bakteri simbion spons yang diambil dari Pulau Barang ...
NATSIR, HASNAH, SENIWATI, PUTRI, NURUL FEBRIANI   +2 more
core  

Role of Nitrogen Source for L-Glutaminase Production from Fungal Strain using through Submerged Fermentation [PDF]

L-glutaminase has attracted much attention due its wide range of applications in several fields. The L-glutaminase widely used in pharmaceutical and food industries. L-glutaminase is generally regarded as a key enzyme that controls the delicious taste of
Krishna, Manjunath Basappa Channi, Harish Kumar T. S, Parimala B   +3 more
core   +1 more source