Results 61 to 70 of about 12,654 (140)
The FEBS Journal, EarlyView.Enteroendocrine L cells function as chemosensors in the intestine. Using the L‐cell line GLUTag, we show that distinct nutrients trigger different combinations of co‐secretion of GLP‐1 and neurotransmitters: D‐glucose evokes GLP‐1, glutamate, and ATP; L‐glutamine evokes GLP‐1 and glutamate; sucralose and butyrate evoke only GLP‐1.
Yo Ito +5 more
wiley +1 more source
Immunology &Cell Biology, EarlyView.Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan +5 more
wiley +1 more source
Obesity Reviews, EarlyView.ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang +4 more
wiley +1 more source
Metabolic reprogramming of the immune response in periodontitis
Periodontology 2000, EarlyView.Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon +3 more
wiley +1 more source
Screening of Actinomycetes from Rhizosphere Soils for L-glutaminase Production
Journal of Pure and Applied MicrobiologyActinomycetes are filamentous, Gram-positive bacteria of major ecological and biomedical importance due to their exceptional ability to produce diverse bioactive secondary metabolites encoded by numerous biosynthetic gene clusters.
Meghana Arivilu +4 more
doaj +1 more source
Biochemistry Research International, 2016 The halophilic bacterial isolates SS1, SS2, SS3, SS5, and SS8 were characterized for production of industrially important enzymes like amylase, protease, lipase, and glutaminase.
Sonika Gupta +3 more
doaj +1 more source
Hypoxia‐induced vulnerability of the somatosensory nervous system
The Journal of Physiology, EarlyView.Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley +1 more source
Cloning and molecular analysis of L-asparaginase II gene (ansB) [PDF]
Journal of BioScience and Biotechnology, 2015 The deamination of L-asparagine to L-aspartic acid and ammonia is catalyzed by L-asparaginases (L-asparagine amino hydrolase). The enzyme L-asparaginase is widely distributed in nature from different living organisms, starting from bacteria till mammals ...
ZEINAT K. MOHAMED +3 more
doaj
Glia, Volume 74, Issue 12, December 2026.Integrated scRNA‐seq from 11 ASD models reveals convergent E/I imbalance and glial dysfunction. Conserved astrocyte and oligodendrocyte dysregulation transcend model‐specific variability. Validated by human datasets. ABSTRACT The etiological heterogeneity of autism spectrum disorder (ASD) complicates identifying core molecular mechanisms.
João V. Nani +3 more
wiley +1 more source