Results 41 to 50 of about 13,194,872 (182)

Characterization and applications of glutaminase free L-asparaginase from indigenous Bacillus halotolerans ASN9.

PLoS ONE, 2023
L-asparaginase (L-ASNase) is a versatile anticancer and acrylamide reduction enzyme predominantly used in medical and food industries. However, the high specificity of L-asparaginase formulations for glutamine, low thermostability, and blood clearance ...
Ifrah Shafqat, Shaheen Shahzad, Azra Yasmin, Muhammad Tausif Chaudhry, Safia Ahmed, Aneela Javed, Imran Afzal, Monaza Bibi   +7 more
doaj   +1 more source

Filamentous Fungi Producing l-Asparaginase with Low Glutaminase Activity Isolated from Brazilian Savanna Soil

Pharmaceutics, 2021
l-asparaginase is an enzyme used as treatment for acute lymphoblastic leukemia (ALL) due to its ability to hydrolyze l-asparagine, an essential amino acid synthesized by normal cells unlike neoplastic cells.
Marcela Freitas, Paula Souza, Samuel Cardoso, Kellen Cruvinel, Letícia Santos Abrunhosa, Edivaldo X. Ferreira Filho, João Inácio, Danilo Batista Pinho, Adalberto Pessoa, Pérola O. Magalhães   +9 more
doaj   +1 more source

DL-3-n-butylphthalide enhances synaptic plasticity in mouse model of brain impairments

STEMedicine, 2022
Synaptic impairment results in cognitive dysfunction of Alzheimer’s disease (AD). As a plant extract, it is found that DL-3-n-butylphthalide (L-NBP) rescues abnormal cognitive behaviors in AD animals.
Qian Ding, Qian Yu, Lei Tao, Yifei Guo, Juan Zhao, Jun Yu   +5 more
doaj   +1 more source

The potential of halophilic and halotolerant bacteria for the production of antineoplastic enzymes: L-asparaginase and L-glutaminase [PDF]

, 2016
L-asparaginase and L-glutaminase can be effectively used for the treatment of patients who suffer from accute lymphoblastic leukemia and tumor cells. Microbial sources are the best source for the bulk production of these enzymes. However, their long-term
Amoozegar, Mohammad Ali, Shirazian, Pejman, Asad, Sedigheh   +2 more
core   +1 more source

Anticancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) capped silver and zinc oxide nanoparticles and its molecular characterization

Bioresources and Bioprocessing
The current investigation reports anti-cancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) and L-Glutaminase capped nanoparticles.
Zabin K. Bagewadi, Gouri H. Illanad, T. M. Yunus Khan, Shaik Mohamed Shamsudeen, Sikandar I. Mulla   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Development of a downstream process for purification and purity analysis of glutaminase free L-asparaginase using UPLC, DLS-ZP and DSC-TGA

Journal of Taibah University for Science, 2021
Several bacterial strains were isolated from soil and water in the current work and screened for glutaminase-free L-asparaginase activity. The selected strain was subjected to the production of glutaminase-free L-asparaginase and thereby purification ...
Pragya Prakash, Sanjeev Chandrayan, Purnima Tiwari, Hare Ram Singh, Santosh Kumar Jha   +4 more
doaj   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Biochemical and biological evaluation of L-glutaminase from Aspergillus tamarii AUMC 10198 via solid-state fermentation

Microbial Cell Factories
Introduction Fungal L-glutaminase has recently attracted growing interest due to its potential applications in medical therapy and biotechnology. This study aimed to develop a cost-effective bioprocess for L-glutaminase production using agricultural by ...
Ghada A. Youssef, Maii S. Zaid, Amany S. Youssef, Samy El-Aassar   +3 more
doaj   +1 more source

Enhanced production of glutaminase-free l-asparaginase by marine Bacillus velezensis and cytotoxic activity against breast cancer cell lines

Electronic Journal of Biotechnology, 2019
Background: The increasing rate of breast cancer globally requires extraordinary efforts to discover new effective sources of chemotherapy with fewer side effects.
Yasser Mostafa, Suliman Alrumman, Saad Alamri, Mohamed Hashem, Kholood Al-izran, Mohammad Alfaifi, Serag Eldin Elbehairi, Tarek Taha   +7 more
doaj   +1 more source