Results 11 to 20 of about 12,654 (140)

Evidence of Antioxidant Activity of Novel L-Glutaminase Purified from L. Gasseri BRLHM [PDF]

Journal of Applied Sciences and Nanotechnology, 2021
Probiotic strains have the potential to be used as bio-preservatives and functional radical scavenging treatments in the future.  Antioxidant tests, including DPPH radical scavenging, were used to evaluate the antioxidant effects of extracellular L ...
Butheina Hasson, Likaa Mahdi, Rajwa Essa
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Immunogenicity assessment of antileukemic agent glutaminase from Escherichia coli, Pseudomonas sp., and Bacillus sp.

Biomedical and Biotechnology Research Journal, 2022
Background: L-glutaminase (L-glutaminase or glutamine amidohydrolase: EC 3.5.1.2) is an antileukemic agent which catalyzes the deamidation of glutamine to glutamic acid and ammonia.
Jyotsna Parmar, Shikha Tripathi, Awanish Kumar   +2 more
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Optimizing the Production of Glutaminase-Free L-Asparaginase by Halotolerant Penicillium sp. Isolated from Halophyte Cogongrass Rhizosphere [PDF]

Delta Journal of Science, 2023
L-asparaginase is an enzyme included in the treatment of acute lymphoblastic leukemia (ALL). Its thrabiutic mechanism is the hydrolyzes of l-asparagine, which is essential amino acid for neoplastic cells while not essential and can be synthesized by ...
Abd El-Raheem El-Shanshoury, Hadeer Abosamra, Tamer ElSakhawy   +2 more
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Production, characterization, and antitumor efficiency of l-glutaminase from halophilic bacteria

Bulletin of the National Research Centre, 2022
Background Halophiles are an excellent source of enzymes that are not only salt stable, but also can withstand and carry out reaction efficiently under extreme conditions.
Eman Zakaria Gomaa
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Bioprospecting of the agaricomycete Ganoderma australe GPC191 as novel source for l-asparaginase production

Scientific Reports, 2021
l-Asparaginase is a therapeutically and industrially-competent enzyme, acting predominantly as an anti-neoplastic and anti-cancerous agent. The existing formulations of prokaryotic l-asparaginase are often toxic and contain l-glutaminase and urease ...
Meghna Chakraborty, Srividya Shivakumar
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In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia

Haematologica, 2022
Asparagine is a non-essential amino acid since it can either be taken up via the diet or synthesized by asparagine synthetase. Acute lymphoblastic leukemia (ALL) cells do not express asparagine synthetase or express it only minimally, which makes them ...
Maaike Van Trimpont, Amanda M. Schalk, Yanti De Visser, Hien Anh Nguyen, Lindy Reunes, Katrien Vandemeulebroecke, Evelien Peeters, Ying Su, Hyun Lee, Philip L. Lorenzi, Wai-Kin Chan, Veerle Mondelaers, Barbara De Moerloose, Tim Lammens, Steven Goossens, Pieter Van Vlierberghe, Arnon Lavie   +16 more
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Metabolic Heterogeneity, Plasticity, and Adaptation to “Glutamine Addiction” in Cancer Cells: The Role of Glutaminase and the GTωA [Glutamine Transaminase—ω-Amidase (Glutaminase II)] Pathway

Biology, 2023
Many cancers utilize l-glutamine as a major energy source. Often cited in the literature as “l-glutamine addiction”, this well-characterized pathway involves hydrolysis of l-glutamine by a glutaminase to l-glutamate, followed by oxidative deamination, or
Arthur J. L. Cooper, Thambi Dorai, John T. Pinto, Travis T. Denton   +3 more
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Bioprospecting of Marine Fungi from Coastal Karnataka Region as Potential Source of Economically Important Enzyme L-Glutaminase and their Comparative Genomic Study

Journal of Pure and Applied Microbiology, 2023
Marine fungi are important sources of new metabolites including certain enzymes of medical interest due to their enormous capacity to adapt themselves to extreme environments.
Sumangala Rao, Monika Sadananda, T.P.M. Pakkala, K.B. Shenoy   +3 more
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Molecular Evaluating the Therapeutic Application of Anticancer L-glutaminase Enzyme on Genetic Mutation Induced Rats

Tikrit Journal for Agricultural Sciences, 2021
The Genomic DNA had been extracted from the liver tissue of the experimental rat groups following 15 weeks of treatment with partial purified L-glutaminase enzyme from E.coli in relation with ethylamine.
Abdalkaleq K. Suleman, Gulbahar F. Karim, Saad Dhamin Oleiwi, Karkaz M. Thalij   +3 more
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Evaluating Therapeutic Characteristics of Anticancer L -Glutaminase Enzyme on Ethylenimine Induced Mutagens in Rats. [PDF]

Kirkuk Journal of Science, 2018
This study include, the partial purification of L-glutaminase enzyme from E.coli by ammonium sulphate precipitation (40%-80%) fractions, and the enzyme activity elevated to 75 IU/ml following dialysis.
Gulbahar Karim, Karkaz Thalij
doaj   +1 more source