Results 11 to 20 of about 11,907 (183)
Production, characterization, and antitumor efficiency of l-glutaminase from halophilic bacteria [PDF]
Bulletin of the National Research Centre, 2022 Background Halophiles are an excellent source of enzymes that are not only salt stable, but also can withstand and carry out reaction efficiently under extreme conditions.
Eman Zakaria Gomaa
doaj +2 more sources
Evidence of Antioxidant Activity of Novel L-Glutaminase Purified from L. Gasseri BRLHM [PDF]
Journal of Applied Sciences and Nanotechnology, 2021 Probiotic strains have the potential to be used as bio-preservatives and functional radical scavenging treatments in the future. Antioxidant tests, including DPPH radical scavenging, were used to evaluate the antioxidant effects of extracellular L ...
Butheina Hasson, Likaa Mahdi, Rajwa Essa
doaj +1 more source
Biomedical and Biotechnology Research Journal, 2022 Background: L-glutaminase (L-glutaminase or glutamine amidohydrolase: EC 3.5.1.2) is an antileukemic agent which catalyzes the deamidation of glutamine to glutamic acid and ammonia.
Jyotsna Parmar +2 more
doaj +1 more source
Kinetic properties of Streptomyces canarius L- Glutaminase and its anticancer efficiency. [PDF]
Braz J Microbiol, 2015 L-glutaminase was produced by Streptomyces canarius FR (KC460654) with an apparent molecular mass of 44 kDa. It has 17.9 purification fold with a final specific activity 132.2 U/mg proteins and 28% yield recovery. The purified L-glutaminase showed a maximal activity against L-glutamine when incubated at pH 8.0 at 40 °C for 30 min.
Reda FM.
europepmc +6 more sources
Optimizing the Production of Glutaminase-Free L-Asparaginase by Halotolerant Penicillium sp. Isolated from Halophyte Cogongrass Rhizosphere [PDF]
Delta Journal of Science, 2023 L-asparaginase is an enzyme included in the treatment of acute lymphoblastic leukemia (ALL). Its thrabiutic mechanism is the hydrolyzes of l-asparagine, which is essential amino acid for neoplastic cells while not essential and can be synthesized by ...
Abd El-Raheem El-Shanshoury +2 more
doaj +1 more source
In vitro Cytocidal Effect of L-Glutaminase on Leukaemic Lymphocytes [PDF]
Nature, 1971 MOUSE lymphomas, such as 6C3HED, undergo complete regression after one or more injections of L-asparaginase1, and remissions have been reported in some patients with acute leukaemia after treatment with L-asparaginase2–4. Roberts et al.5 found that purified bacterial L-glutaminase inhibited the growth of Ehrlich mouse carcinoma. Before considering this
R, Schrek +3 more
openaire +2 more sources
Scientific Reports, 2021 l-Asparaginase is a therapeutically and industrially-competent enzyme, acting predominantly as an anti-neoplastic and anti-cancerous agent. The existing formulations of prokaryotic l-asparaginase are often toxic and contain l-glutaminase and urease ...
Meghna Chakraborty, Srividya Shivakumar
doaj +1 more source
Haematologica, 2022 Asparagine is a non-essential amino acid since it can either be taken up via the diet or synthesized by asparagine synthetase. Acute lymphoblastic leukemia (ALL) cells do not express asparagine synthetase or express it only minimally, which makes them ...
Maaike Van Trimpont +16 more
doaj +1 more source
Biology, 2023 Many cancers utilize l-glutamine as a major energy source. Often cited in the literature as “l-glutamine addiction”, this well-characterized pathway involves hydrolysis of l-glutamine by a glutaminase to l-glutamate, followed by oxidative deamination, or
Arthur J. L. Cooper +3 more
doaj +1 more source
Journal of Pure and Applied Microbiology, 2023 Marine fungi are important sources of new metabolites including certain enzymes of medical interest due to their enormous capacity to adapt themselves to extreme environments.
Sumangala Rao +3 more
doaj +1 more source