Results 61 to 70 of about 312,266 (316)

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Novel synthetic co‐culture of Acetobacterium woodii and Clostridium drakei using CO2 and in situ generated H2 for the production of caproic acid via lactic acid

Engineering in Life Sciences, 2023
Acetobacterium woodii is known to produce mainly acetate from CO2 and H2, but the production of higher value chemicals is desired for the bioeconomy.
Jan Herzog, Alexander Mook, Lotta Guhl, Miriam Bäumler, Matthias H. Beck, Dirk Weuster‐Botz, Frank R. Bengelsdorf, An‐Ping Zeng   +7 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Increase of optical purtiy of L-lactic produced by engineered Escherichia coli by enhancing anaerobic expression of dld gene [PDF]

Zhongguo niangzao
In order to eliminate D-lactic acid in cheap fermentation raw materials and improve the optical purity of L-lactic acid in fermentation final product, the expression plasmids of D-lactate dehydrogenase gene (dld) with different anaerobic inducible ...
YU Jie, LI Zheng, WANG Jinhua, WANG Yongze, GAO Wa, ZHAO Xiao
doaj   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

FEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya, Ksenia V. Sergeeva, Boris S. Shenkman, Timur M. Mirzoev   +3 more
wiley   +1 more source

Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate

BMC Microbiology, 2010
Background Corynebacterium glutamicum is able to grow with lactate as sole or combined carbon and energy source. Quinone-dependent L-lactate dehydrogenase LldD is known to be essential for utilization of L-lactate by C. glutamicum.
Oikawa Tadao, Matsui Daisuke, Stansen K Corinna, Youn Jung-Won, Kato Osamu, Wendisch Volker F   +5 more
doaj   +1 more source

Clinical features and prognostic factors in patients with bone metastases from non-small cell lung cancer

Journal of International Medical Research, 2020
Objective To investigate the clinical features and evaluate the prognostic factors in patients with bone metastases from non-small cell lung cancer (NSCLC). Methods We retrospectively investigated 356 patients with NSCLC with bone metastases from January
Xiao-Tian Wu, Jian-Wei Zhou, Long-Ci Pan, Ting Ge   +3 more
doaj   +1 more source

Co-Production of Isoprene and Lactate by Engineered Escherichia coli in Microaerobic Conditions

Molecules, 2021
Lactate and isoprene are two common monomers for the industrial production of polyesters and synthetic rubbers. The present study tested the co-production of D-lactate and isoprene by engineered Escherichia coli in microaerobic conditions.
Tao Cheng, Xiuhong Liang, Yaqun Wang, Ningning Chen, Dexin Feng, Fengbing Liang, Congxia Xie, Tao Liu, Huibin Zou   +8 more
doaj   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Influence of L-lactate and low glucose concentrations on the metabolism and the toxin formation of Clostridioides difficile.

PLoS ONE, 2021
The virulence of Clostridioides difficile (formerly Clostridium difficile) is mainly caused by its two toxins A and B. Their formation is significantly regulated by metabolic processes.
Julia Danielle Hofmann, Rebekka Biedendieck, Annika-Marisa Michel, Dietmar Schomburg, Dieter Jahn, Meina Neumann-Schaal   +5 more
doaj   +1 more source