The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study [PDF]
Frontiers in Endocrinology, 2023 ObjectiveChronic hyperglycemia induces pathogenic changes in the vascular endothelium and leads to the development of microvascular complications in patients with type 2 diabetes mellitus.
Khalid Siddiqui +8 more
doaj +4 more sources
L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling [PDF]
Frontiers in Immunology, 2019 L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterized as a tethering/rolling receptor.
Aleksandar Ivetic +2 more
doaj +4 more sources
The Role of L-Selectin in HIV Infection [PDF]
Frontiers in Microbiology, 2021 HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface. This glycan canopy is thought to primarily shield the virus from host immune recognition as glycans are poor immunogens in ...
Jason Segura +6 more
doaj +4 more sources
Facile supermolecular aptamer inhibitors of L-selectin. [PDF]
PLoS ONE, 2015 Multivalent interactions occur frequently in nature, where they mediate high-affinity interactions between cells, proteins, or molecules. Here, we report on a method to generate multivalent aptamers (Multi-Aptamers) that target L-selectin function using ...
Elizabeth K Chang +6 more
doaj +7 more sources
Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin [PDF]
Biomedicines, 2021 The pleiotropic effects of statins might involve preventing inflammatory cell adhesion to the endothelium, which is a critical step in the pathogenesis of atherosclerosis.
Angelo Zinellu, Arduino A. Mangoni
doaj +2 more sources
Immune Responses to IAV Infection and the Roles of L-Selectin and ADAM17 in Lymphocyte Homing [PDF]
Pathogens, 2022 Influenza A virus (IAV) infection is a global public health burden causing up to 650,000 deaths per year. Yearly vaccination programmes and anti-viral drugs currently have limited benefits; therefore, research into IAV is fundamental.
Sophie G. Reed, Ann Ager
doaj +2 more sources
Chemoattractant Receptor-induced Phosphorylation of L-selectin [PDF]
Journal of Biological Chemistry, 1997 The selectin adhesion molecules and chemoattractant receptors synergistically regulate leukocyte migration into lymphoid tissues and sites of inflammation, but little is known about how these families of receptors modulate each other's function. In this study, L-selectin was found to be phosphorylated in lymphoblastoid cell lines, and phosphorylation ...
Bodduluri Haribabu +5 more
openalex +5 more sources
L-selectin regulates human neutrophil transendothelial migration. [PDF]
J Cell Sci, 2021 ABSTRACT The migration of circulating neutrophils towards damaged or infected tissue is absolutely critical to the inflammatory response. L-selectin is a cell adhesion molecule abundantly expressed on circulating neutrophils. For over two decades, neutrophil L-selectin has been assigned the exclusive role of supporting tethering and ...
Rahman I +11 more
europepmc +6 more sources
P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces. [PDF]
PLoS ONE, 2013 Interactions of selectins with cell surface glycoconjugates mediate the first step of the adhesion and signaling cascade that recruits circulating leukocytes to sites of infection or injury.
Yan Zhang +5 more
doaj +3 more sources
L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2019 The homing molecule, L-selectin (CD62L), is commonly used as a T cell activation marker, since expression is downregulated following engagement of the T cell receptor.
H. Angharad Watson +13 more
doaj +2 more sources